primary analysis for grade2 AEs

tidycmprsk::crr(Surv(cmp_time_anemia_2,cmp_status_anemia_2) ~+sarcopenia_smi +age+Male+eGFR_CRE+pre_ALB_45days+pre_HGB_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.38 1.06, 1.80 0.018
age 0.99 0.98, 1.01 0.3
Male
    0 — —
    1 0.86 0.67, 1.10 0.2
eGFR_CRE 0.99 0.98, 1.00 0.003
pre_ALB_45days 0.47 0.35, 0.63 <0.001
pre_HGB_45days 0.51 0.46, 0.57 <0.001
paclitax
    0 — —
    1 0.97 0.40, 2.34 >0.9
smoking
    0 — —
    1 1.41 1.06, 1.88 0.019
ppi
    0 — —
    1 1.22 0.91, 1.64 0.2
pemetrex
    0 — —
    1 1.19 0.62, 2.25 0.6
1 HR = Hazard Ratio, CI = Confidence Interval 
tidycmprsk::crr(Surv(cmp_time_throm_2,cmp_status_throm_2) ~sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+paclitax+smoking+ppi+pemetrex+pre_PLT_45days,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.93 1.11, 3.35 0.019
age 0.97 0.93, 1.00 0.090
Male
    0 — —
    1 0.64 0.38, 1.08 0.093
eGFR_CRE 0.98 0.96, 1.00 0.028
pre_ALB_45days 0.27 0.16, 0.46 <0.001
paclitax
    0 — —
    1 0.46 0.09, 2.36 0.4
smoking
    0 — —
    1 2.06 1.08, 3.93 0.028
ppi
    0 — —
    1 0.91 0.51, 1.62 0.7
pemetrex
    0 — —
    1 0.86 0.26, 2.86 0.8
pre_PLT_45days 0.99 0.99, 1.00 <0.001
1 HR = Hazard Ratio, CI = Confidence Interval 
tidycmprsk::crr(Surv(cmp_time_neutro_2,cmp_status_neutro_2) ~sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+pre_ANEU_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.14 0.79, 1.64 0.5
age 1.01 0.99, 1.03 0.6
Male
    0 — —
    1 0.80 0.58, 1.10 0.2
eGFR_CRE 0.99 0.98, 1.00 0.051
pre_ALB_45days 0.70 0.50, 0.99 0.046
pre_ANEU_45days 0.91 0.87, 0.96 <0.001
paclitax
    0 — —
    1 0.56 0.28, 1.13 0.11
smoking
    0 — —
    1 1.26 0.89, 1.77 0.2
ppi
    0 — —
    1 0.91 0.63, 1.30 0.6
pemetrex
    0 — —
    1 0.34 0.21, 0.57 <0.001
1 HR = Hazard Ratio, CI = Confidence Interval 
tidycmprsk::crr(Surv(cmp_time_aki_2,cmp_status_aki_2) ~ sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+paclitax+smoking+ppi+pemetrex,failcde=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 2.10 1.26, 3.50 0.004
age 0.99 0.96, 1.02 0.4
Male
    0 — —
    1 0.33 0.20, 0.56 <0.001
eGFR_CRE 0.98 0.97, 1.00 0.066
pre_ALB_45days 0.48 0.28, 0.84 0.011
paclitax
    0 — —
    1 0.68 0.17, 2.75 0.6
smoking
    0 — —
    1 1.65 0.97, 2.79 0.065
ppi
    0 — —
    1 1.32 0.71, 2.47 0.4
pemetrex
    0 — —
    1 0.71 0.24, 2.09 0.5
1 HR = Hazard Ratio, CI = Confidence Interval

#secondary analysis for side effect, cancer progression,grade3 AEs

tidycmprsk::crr(Surv(cmp_time_side_eff,cmp_status_side_eff) ~ sarcopenia_smi+ +age+Male+eGFR_CRE+pre_ALB_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.07 0.68, 1.70 0.8
age 1.00 0.97, 1.03 0.8
Male
    0 — —
    1 0.92 0.62, 1.37 0.7
eGFR_CRE 0.98 0.97, 1.00 0.007
pre_ALB_45days 0.51 0.33, 0.80 0.003
paclitax
    0 — —
    1 0.30 0.09, 1.02 0.053
smoking
    0 — —
    1 1.75 1.09, 2.81 0.020
ppi
    0 — —
    1 1.80 1.01, 3.19 0.045
pemetrex
    0 — —
    1 0.48 0.21, 1.07 0.072
1 HR = Hazard Ratio, CI = Confidence Interval 
tidycmprsk::crr(Surv(cmp_time_cancer_prog,cmp_status_cancer_prog) ~ sarcopenia_smi++age+Male+eGFR_CRE+pre_ALB_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.22 0.82, 1.80 0.3
age 0.99 0.97, 1.01 0.4
Male
    0 — —
    1 1.01 0.71, 1.45 >0.9
eGFR_CRE 1.0 0.98, 1.01 0.4
pre_ALB_45days 0.33 0.22, 0.49 <0.001
paclitax
    0 — —
    1 1.56 0.39, 6.24 0.5
smoking
    0 — —
    1 0.85 0.59, 1.23 0.4
ppi
    0 — —
    1 1.0 0.66, 1.51 >0.9
pemetrex
    0 — —
    1 1.70 0.52, 5.56 0.4
1 HR = Hazard Ratio, CI = Confidence Interval 
 tidycmprsk::crr(Surv(cmp_time_anemia_3,cmp_status_anemia_3) ~ sarcopenia_smi+ +age+Male+eGFR_CRE+pre_ALB_45days+pre_HGB_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.20 0.77, 1.87 0.4
age 1.00 0.98, 1.03 0.8
Male
    0 — —
    1 0.80 0.53, 1.19 0.3
eGFR_CRE 0.99 0.98, 1.00 0.11
pre_ALB_45days 0.43 0.28, 0.68 <0.001
pre_HGB_45days 0.61 0.52, 0.71 <0.001
paclitax
    0 — —
    1 2.00 0.40, 10.0 0.4
smoking
    0 — —
    1 1.61 1.00, 2.59 0.050
ppi
    0 — —
    1 1.05 0.62, 1.76 0.9
pemetrex
    0 — —
    1 1.73 0.41, 7.38 0.5
1 HR = Hazard Ratio, CI = Confidence Interval 
 tidycmprsk::crr(Surv(cmp_time_throm_3,cmp_status_throm_3) ~ sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+pre_PLT_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.37 0.64, 2.95 0.4
age 0.97 0.93, 1.02 0.2
Male
    0 — —
    1 0.80 0.39, 1.64 0.6
eGFR_CRE 0.97 0.95, 1.0 0.017
pre_ALB_45days 0.21 0.10, 0.47 <0.001
pre_PLT_45days 1.00 0.99, 1.00 0.014
paclitax
    0 — —
    1 0.30 0.04, 2.61 0.3
smoking
    0 — —
    1 1.33 0.58, 3.03 0.5
ppi
    0 — —
    1 0.70 0.30, 1.62 0.4
pemetrex
    0 — —
    1 0.51 0.12, 2.25 0.4
1 HR = Hazard Ratio, CI = Confidence Interval 
 tidycmprsk::crr(Surv(cmp_time_neutro_3,cmp_status_neutro_3) ~ sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+pre_ANEU_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.16 0.71, 1.89 0.6
age 1.00 0.97, 1.03 0.9
Male
    0 — —
    1 0.75 0.48, 1.15 0.2
eGFR_CRE 0.99 0.97, 1.00 0.093
pre_ALB_45days 0.71 0.41, 1.23 0.2
pre_ANEU_45days 0.93 0.87, 0.98 0.012
paclitax
    0 — —
    1 0.49 0.19, 1.24 0.13
smoking
    0 — —
    1 1.48 0.91, 2.39 0.11
ppi
    0 — —
    1 0.74 0.46, 1.22 0.2
pemetrex
    0 — —
    1 0.26 0.14, 0.49 <0.001
1 HR = Hazard Ratio, CI = Confidence Interval 
tidycmprsk::crr(Surv(cmp_time_aki_3,cmp_status_aki_3) ~ sarcopenia_smi+age+Male+eGFR_CRE+pre_ALB_45days+paclitax+smoking+ppi+pemetrex,failcode=1,cencode=0, data = master) %>% tbl_regression(exp = TRUE)
## 1 cases omitted due to missing values
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 154 4.70, 5,063 0.005
age 0.70 0.48, 1.04 0.079
Male
    0 — —
    1 0.26 0.04, 1.54 0.14
eGFR_CRE 0.85 0.71, 1.01 0.070
pre_ALB_45days 0.02 0.00, 1.72 0.086
paclitax
    0 — —
    1 7,856,098 85,728, 719,927,644 <0.001
smoking
    0 — —
    1 63.6 0.11, 37,752 0.2
ppi
    0 — —
    1 229,938 6,016, 8,789,036 <0.001
pemetrex
    0 — —
    1 3,229,195 44,197, 235,935,961 <0.001
1 HR = Hazard Ratio, CI = Confidence Interval

1 YEAR Death coxph

coxph(Surv(time_to_death_365,death_365) ~sarcopenia_smi+age+Male+carbo+BMI_updated+eGFR_CRE+pre_ALB_45days+pre_HGB_45days+pre_PLT_45days+pre_ANEU_45days+paclitax+smoking+ppi+pemetrex+cad+hiv+dm+htn+dm+diu, data = master) %>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
sarcopenia_smi
    0 — —
    1 1.47 1.09, 1.99 0.012
age 0.99 0.97, 1.01 0.4
Male
    0 — —
    1 0.86 0.65, 1.15 0.3
carbo 2.54 0.82, 7.89 0.11
BMI_updated 1.02 1.00, 1.05 0.11
eGFR_CRE 1.00 0.99, 1.01 0.6
pre_ALB_45days 0.32 0.23, 0.44 <0.001
pre_HGB_45days 0.93 0.85, 1.01 0.10
pre_PLT_45days 1.00 1.00, 1.00 0.6
pre_ANEU_45days 1.02 1.00, 1.05 0.061
paclitax
    0 — —
    1 0.48 0.11, 2.05 0.3
smoking
    0 — —
    1 0.95 0.71, 1.27 0.7
ppi
    0 — —
    1 0.92 0.67, 1.27 0.6
pemetrex
    0 — —
    1 0.96 0.25, 3.62 >0.9
cad
    0 — —
    1 1.39 1.03, 1.90 0.034
hiv
    0 — —
    1 2.52 1.15, 5.51 0.021
dm
    0 — —
    1 0.95 0.68, 1.31 0.7
htn
    0 — —
    1 1.14 0.82, 1.57 0.4
diu
    0 — —
    1 1.02 0.77, 1.37 0.9
1 HR = Hazard Ratio, CI = Confidence Interval