PYP amyloid ASNC abstract WITHOUT HEREDITARY TTR
General information:
Basic information
Metadata and analysis of the file April 13 mci.xlsx
Each row represents one patient.
Date of data collection:
2017-07-01 to 2024-01-01
Location of data collection:
Hartford, CT, USA
Number of observations:
109
Number of variables:
106
Data on regions
Region 3 (all segments)
| term | df | sumsq | meansq | statistic | p.value |
|---|---|---|---|---|---|
| region3 | 16 | 204.5466 | 12.784161 | 5.134184 | 1.261235e-10 |
| Residuals | 1836 | 4571.6550 | 2.490008 | NA | NA |
Region 2
| term | df | sumsq | meansq | statistic | p.value |
|---|---|---|---|---|---|
| region2 | 8 | 114.3006 | 14.287581 | 5.651407 | 4.124851e-07 |
| Residuals | 1844 | 4661.9010 | 2.528146 | NA | NA |
Region 1
| term | df | sumsq | meansq | statistic | p.value |
|---|---|---|---|---|---|
| region1 | 2 | 42.79112 | 21.39556 | 8.362213 | 0.000242468 |
| Residuals | 1850 | 4733.41049 | 2.55860 | NA | NA |
Characterisics of our group
| Characteristic | N = 1091 |
|---|---|
| end_exam_time | 2017-07-22 to 2024-01-12 |
| finalizing_physician | |
| chaudhry, waseem | 1 (0.9%) |
| duvall, william l | 67 (62%) |
| fernandez, antonio b | 7 (6.5%) |
| golub, robert j | 2 (1.9%) |
| mcmahon, sean r | 16 (15%) |
| nadig, vidya | 8 (7.4%) |
| saucier, stephanie j | 7 (6.5%) |
| Unknown | 1 |
| imaging_delay_minutes | 68 (62, 95) |
| tc_dose | 15.60 (14.60, 18.93) |
| exponent | 0.19 (0.17, 0.26) |
| half_life | 0.88 (0.83, 0.89) |
| tc_dose_imaging | 13.54 (12.52, 16.19) |
| study_results_positive_equivocal | |
| positive | 109 (100%) |
| planar_ratio | 1.69 (1.54, 1.85) |
| Unknown | 24 |
| visual_score_based_on_report | |
| 1 | 1 (1.1%) |
| 2 | 10 (11%) |
| 2.5 | 5 (5.4%) |
| 3 | 76 (83%) |
| Unknown | 17 |
| visual_score_based_on_planar | |
| 2 | 5 (18%) |
| 3 | 23 (82%) |
| Unknown | 81 |
| blood_pool_n_0_y_1_unknown_2 | 1 (13%) |
| Unknown | 101 |
| ct_scan_done | 70 (82%) |
| Unknown | 24 |
| demographics | |
| black or african american | 6 (7.1%) |
| hispanic or latino | 2 (2.4%) |
| other | 1 (1.2%) |
| white or caucasian | 76 (89%) |
| Unknown | 24 |
| date_of_birth | 1921-08-28 to 1963-02-17 |
| Unknown | 24 |
| age | 81 (76, 85) |
| gender | |
| female | 13 (12%) |
| male | 96 (88%) |
| height_inches | 69.0 (66.0, 71.0) |
| height_meters | 1.75 (1.68, 1.80) |
| weight_pounds | 175 (146, 199) |
| weight_kg | 79 (66, 90) |
| bmi | 25.5 (23.2, 28.7) |
| ef | 55 (40, 60) |
| Unknown | 24 |
| dm_yes_1 | |
| 0 | 62 (73%) |
| 1 | 21 (25%) |
| pre-dm | 2 (2.4%) |
| Unknown | 24 |
| htn_yes_1 | 67 (79%) |
| Unknown | 24 |
| hld_yes_1 | 66 (78%) |
| Unknown | 24 |
| tobacco_no_0_yes_1_former_2_unknown_3 | |
| 0 | 33 (39%) |
| 2 | 50 (59%) |
| 3 | 2 (2.4%) |
| Unknown | 24 |
| aortic_stenosis_no_0_mod_severe_1_s_p_tavr_2 | |
| 0 | 70 (82%) |
| 1 | 8 (9.4%) |
| 2 | 7 (8.2%) |
| Unknown | 24 |
| cad_50_percent_yes_1 | |
| 0 | 65 (76%) |
| 1 | 18 (21%) |
| 2 | 2 (2.4%) |
| Unknown | 24 |
| gfr_time_of_pyp | 52 (38, 60) |
| Unknown | 25 |
| gfr_60_yes_1 | 34 (40%) |
| Unknown | 25 |
| al_workup_yes_1 | 77 (92%) |
| Unknown | 25 |
| al_workup_results_abnormal_1 | |
| 0 | 31 (40%) |
| 1 | 47 (60%) |
| Unknown | 31 |
| cardiac_biopsy_yes_1 | 8 (9.5%) |
| Unknown | 25 |
| biopsy_positive_yes_1 | |
| 0 | 12 (60%) |
| 1 | 8 (40%) |
| Unknown | 89 |
| final_clinical_diagnosis_amyloid_1 | |
| ? | 2 (2.4%) |
| 0 | 1 (1.2%) |
| 1 | 82 (96%) |
| Unknown | 24 |
| amyloid_type_al_0_attr_1_other_2 | |
| 1 | 79 (99%) |
| 2 | 1 (1.3%) |
| Unknown | 29 |
| w_attr_0_m_attr_1_unknown_2 | |
| 0 | 59 (75%) |
| 2 | 20 (25%) |
| Unknown | 30 |
| pyp_date | 2017-07-22 to 2023-02-21 |
| Unknown | 17 |
| non_attenuation_corrected_raw_counts | 0 (NA%) |
| Unknown | 109 |
| x1_basal_anterior | 73 (61, 78) |
| x2_basal_anteroseptal | 72 (60, 78) |
| x3_basal_inferoseptal | 73 (61, 81) |
| x4_basal_inferior | 72 (60, 80) |
| x5_basal_inferolateral | 70 (58, 80) |
| x6_basal_anterolateral | 72 (60, 80) |
| x7_mid_anterior | 71 (61, 79) |
| x8_mid_anteroseptal | 85 (75, 89) |
| x9_mid_inferoseptal | 90 (76, 94) |
| x10_mid_inferior | 75 (64, 83) |
| x11_mid_inferolateral | 70 (59, 80) |
| x12_mid_anterolateral | 71 (60, 80) |
| x13_apical_anterior | 67 (54, 77) |
| x14_apical_septal | 78 (65, 87) |
| x15_apical_inferior | 72 (60, 79) |
| x16_apical_lateral | 66 (53, 75) |
| x17_apex | 65 (52, 77) |
| non_attenuation_corrected_counts_per_m_ci | 0 (NA%) |
| Unknown | 109 |
| x1_basal_anterior_2 | 4.86 (3.85, 5.76) |
| x2_basal_anteroseptal_2 | 4.87 (3.74, 5.67) |
| x3_basal_inferoseptal_2 | 4.96 (3.93, 6.04) |
| x4_basal_inferior_2 | 4.95 (3.61, 5.84) |
| x5_basal_inferolateral_2 | 4.84 (3.81, 5.93) |
| x6_basal_anterolateral_2 | 5.01 (3.87, 5.90) |
| x7_mid_anterior_2 | 4.92 (4.02, 5.67) |
| x8_mid_anteroseptal_2 | 5.72 (4.65, 6.50) |
| x9_mid_inferoseptal_2 | 5.91 (4.73, 7.07) |
| x10_mid_inferior_2 | 5.14 (3.95, 6.19) |
| x11_mid_inferolateral_2 | 4.88 (3.78, 5.64) |
| x12_mid_anterolateral_2 | 4.94 (3.81, 5.66) |
| x13_apical_anterior_2 | 4.57 (3.67, 5.31) |
| x14_apical_septal_2 | 5.24 (4.29, 6.14) |
| x15_apical_inferior_2 | 4.86 (3.97, 5.70) |
| x16_apical_lateral_2 | 4.86 (3.97, 5.70) |
| x17_apex_2 | 4.42 (3.62, 5.37) |
| segmental_counts_per_m_ci | 0 (NA%) |
| Unknown | 109 |
| total_counts_base | 30 (23, 35) |
| total_counts_mid | 32 (25, 36) |
| total_counts_apical | 24 (20, 28) |
| x1_basal_anterior_3 | -5.2 (-8.5, -3.0) |
| Unknown | 40 |
| x2_basal_anteroseptal_3 | -2.8 (-5.0, 0.0) |
| Unknown | 40 |
| x3_basal_inferoseptal_3 | -2.00 (-4.00, -0.30) |
| Unknown | 40 |
| x4_basal_inferior_3 | -4.2 (-6.8, -1.3) |
| Unknown | 40 |
| x5_basal_inferolateral_3 | -8 (-13, -3) |
| Unknown | 40 |
| x6_basal_anterolateral_3 | -6.8 (-11.4, -3.1) |
| Unknown | 40 |
| x7_mid_anterior_3 | -7.3 (-10.8, -3.4) |
| Unknown | 40 |
| x8_mid_anteroseptal_3 | -8.0 (-12.3, -3.5) |
| Unknown | 40 |
| x9_mid_inferoseptal_3 | -6.2 (-10.5, -3.2) |
| Unknown | 40 |
| x10_mid_inferior_3 | -6.0 (-9.0, -3.4) |
| Unknown | 40 |
| x11_mid_inferolateral_3 | -4.3 (-7.1, -2.8) |
| Unknown | 40 |
| x12_mid_anterolateral_3 | -4.9 (-8.1, -2.0) |
| Unknown | 40 |
| x13_apical_anterior_3 | -13 (-17, -4) |
| Unknown | 40 |
| x14_apical_septal_3 | -10 (-16, -4) |
| Unknown | 40 |
| x15_apical_inferior_3 | -11 (-18, -5) |
| Unknown | 40 |
| x16_apical_lateral_3 | -7.8 (-12.6, -4.9) |
| Unknown | 40 |
| global | -7.5 (-10.2, -4.1) |
| Unknown | 40 |
| attr_type | |
| w_attr | 59 (100%) |
| Unknown | 50 |
| average_counts_corrected | 5.00 (4.10, 5.80) |
| 1 Range; n (%); Median (IQR) | |
Analysis of subgroups
Gender
| gender | mean_counts | n |
|---|---|---|
| female | 5.19 | 13 |
| male | 4.88 | 96 |
Basal to apex analysis females
Basal to apex analysis males
Visual score
| visual_score_based_on_report | mean_counts | n |
|---|---|---|
| 1.0 | 3.90 | 1 |
| 2.0 | 4.67 | 10 |
| 2.5 | 5.08 | 5 |
| 3.0 | 5.13 | 76 |
| NA | 4.12 | 17 |
ATTR Type
| attr_type | mean_counts | n |
|---|---|---|
| w_attr | 5.26 | 59 |
| NA | 4.52 | 50 |
ASR apical-sparing ratio (ASR)
Formula: ratio = (basal_mean + mid_mean) / apical_mean
Overall: 2.0865204
Male: 2.0855752
Female: 2.0930803