Load data

TAD from Insulation Score

IS - TAD size

##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    65000   185000   265000   374547   400000 24490000




w = 500 + h = 1100. PreciseTAD with sliding window of 500 (5KB resolution) and smoothing h = 1100

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1  1020000   2060000    1530000        0.3739284     0.03921569       0
## 2  1020000   2410000    1720000        0.5694892     0.01449275       0
## 3  1785000   1925000    1855000        0.4547684     0.00000000       0
## 4  1925000   2060000    1990000        0.2613912     0.07692308       0
## 5  1645000   1785000    1720000        0.2866044     0.15384615       0
## 6  1925000   2060000    1990000        0.2613912     0.07692308       0
##   actual_size
## 1     1040000
## 2     1390000
## 3      140000
## 4      135000
## 5      140000
## 6      135000
## Summary of size is:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##   55000  140000  170000  540875  820000 2390000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   40000   77269  115000  600000

## [1] "Number of overlapped TAD is 25"




w = 2000 + h = 1100. PreciseTAD with sliding window of 2000 (5KB resolution) and smoothing h = 1100

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   900000   2555000    1720000        0.6347220     0.01829268       0
## 2  2410000   2555000    2480000        0.5139072     0.07142857       0
## 3  2555000   3455000    2995000        0.8111084     0.04545455       0
## 4  2555000   3655000    3080000        0.8177772     0.09523810       0
## 5  2555000   3655000    3105000        0.8356176     0.00000000       0
## 6  2555000   3890000    3200000        0.8205000     0.06976744       0
##   actual_size
## 1     1655000
## 2      145000
## 3      900000
## 4     1100000
## 5     1100000
## 6     1335000
## Summary of size is:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##   55000  175000 1255000 1584748 2707500 4875000
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   42500   77500  115000  600000

## [1] "Number of overlapped TAD is 25"




w = 5000 + h = 1100. PreciseTAD with sliding window of 5000 (5KB resolution) and smoothing h = 1100

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   900000   2555000    1720000        0.6347220     0.01829268       0
## 2  2410000   2555000    2480000        0.5139072     0.07142857       0
## 3  2555000   3455000    2995000        0.8111084     0.04545455       0
## 4  2555000   3655000    3080000        0.8177772     0.09523810       0
## 5  2555000   3655000    3105000        0.8356176     0.00000000       0
## 6  2555000   3890000    3200000        0.8205000     0.06976744       0
##   actual_size
## 1     1655000
## 2      145000
## 3      900000
## 4     1100000
## 5     1100000
## 6     1335000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    55000   376250  3617500  4547469  7705000 14835000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   45000   79464  120000  600000

## [1] "Number of overlapped TAD is 26"




w = 7000 + h = 1100. PreciseTAD with sliding window of 7000 (5KB resolution) and smoothing h = 1100

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   265000  26840000   12910000        0.8104820     0.10162119       0
## 2   265000  26840000   12955000        0.8065008     0.09416864       0
## 3   265000  26840000   13020000        0.8179160     0.08349667       0
## 4   265000  26840000   13055000        0.8068556     0.07779515       0
## 5   265000  26840000   13135000        0.7944448     0.06487956       0
## 6   265000  26840000   13165000        0.7721396     0.06007752       0
##   actual_size
## 1    26575000
## 2    26575000
## 3    26575000
## 4    26575000
## 5    26575000
## 6    26575000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    55000   356250  8157500  9855754 16195000 34615000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   45000   80099  121250  600000

## [1] "Number of overlapped TAD is 25"




w = 5000 + h = 1500. PreciseTAD with sliding window of 5000 (5KB resolution) and smoothing h = 1500

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   265000  11050000    5435000        0.6811744    0.086073501       0
## 2   265000  11050000    5575000        0.6442028    0.031073446       0
## 3   265000  11050000    5680000        0.6888628    0.008379888       0
## 4   265000  11050000    5840000        0.6877072    0.070057582       0
## 5   890000  11050000    5975000        0.1503184    0.001970443       0
## 6  1115000  11050000    6290000        0.6579256    0.087184874       0
##   actual_size
## 1    10785000
## 2    10785000
## 3    10785000
## 4    10785000
## 5    10160000
## 6     9935000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    55000   320000  5450000  6788238 11620000 24145000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   50000   77549  110000  600000

## [1] "Number of overlapped TAD is 35"

w = 5000 + h = 2000. PreciseTAD with sliding window of 5000 (5KB resolution) and smoothing h = 1500

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   265000  24835000   11935000        0.5076636     0.10539846       0
## 2   265000  24835000   12010000        0.1136124     0.09195402       0
## 3   265000  24835000   12090000        0.1672428     0.07780127       0
## 4   265000  24835000   12170000        0.1524768     0.06383872       0
## 5   265000  24835000   12245000        0.2153376     0.05091820       0
## 6   265000  24835000   12360000        0.5901984     0.03141794       0
##   actual_size
## 1    24570000
## 2    24570000
## 3    24570000
## 4    24570000
## 5    24570000
## 6    24570000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    45000   302500  6995000  7749693 13135000 24570000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   15000   55000   79396  110000  600000

## [1] "Number of overlapped TAD is 42"




w = 5000 + h = 4000. PreciseTAD with sliding window of 5000 (5KB resolution) and smoothing h = 1500

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   265000   9620000    4695000        0.6041520     0.11173815       0
## 2   265000   9620000    4755000        0.6997348     0.08351893       0
## 3   265000   9620000    4980000        0.7866904     0.01616379       0
## 4   265000   9620000    5030000        0.8169944     0.03812636       0
## 5   265000   9620000    5100000        0.8180908     0.06969027       0
## 6   265000   9620000    5155000        0.8180908     0.09518477       0
##   actual_size
## 1     9355000
## 2     9355000
## 3     9355000
## 4     9355000
## 5     9355000
## 6     9355000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    30000   410000  6180000  7313187 12245000 23885000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   20000   55000   78654  110000  600000

## [1] "Number of overlapped TAD is 43"




w = 5000 + h = 7000. PreciseTAD with sliding window of 5000 (5KB resolution) and smoothing h = 1500

e = 0.1 and t = 0.1

Arm1

##   left_TAD right_TAD center_TAD averageProb_diff error_symetric overlap
## 1   265000   9625000    4755000        0.6997348    0.084632517       0
## 2   265000   9625000    4895000        0.6989204    0.021598272       0
## 3   265000   9625000    4920000        0.7403324    0.010741139       0
## 4   265000   9625000    4965000        0.7715184    0.008583691       0
## 5   265000   9625000    4985000        0.8039476    0.017241379       0
## 6   265000   9625000    5030000        0.8169944    0.036996736       0
##   actual_size
## 1     9360000
## 2     9360000
## 3     9360000
## 4     9360000
## 5     9360000
## 6     9360000
## Summary of size is:
##     Min.  1st Qu.   Median     Mean  3rd Qu.     Max. 
##    20000   927500  5880000  6978387 11575000 22085000
## Summary of distance from preciseTAD and closest IS boundary:
##    Min. 1st Qu.  Median    Mean 3rd Qu.    Max. 
##       0   20000   55000   79036  110000  600000

## [1] "Number of overlapped TAD is 46"