Denali IVC filter study

Author

Lu Mao

Statistical analysis

Variables are compared between caval thrombosis vs non-caval thrombosis and between worsening clot vs non-worsening clot below. Quantitative variables are summarized by median (inter-quartile range; IQR) and tested by the Wilcoxon rank sum test; Categorical variables are summarized by N (%) and tested by the Fisher exact test.

Variable correlations with caval thrombosis

Table 1: Variables by caval thrombosis (CT) status.
Non-CT (N=486) CT (N=20) p-value
Hypercoagulable Disorder - No 470(96.7%) 18(90%) 0.1555
Hypercoagulable Disorder - Yes 16(3.3%) 2(10%)
Filter Indication - Anticoagulation Failure 41(8.4%) 2(10%) 0.0509
Filter Indication - Calf DVT in neurosurgery patient 19(3.9%) 1(5%)
Filter Indication - DVT or PE with contraindication to anticoagulation 363(74.7%) 15(75%)
Filter Indication - Prophylactic 56(11.5%) 0(0%)
Filter Indication - Other 7(1.4%) 2(10%)
Dwell time (days) 106.5 (70, 160) 213 (105, 279) 0.01
Retrieval Intent - Non-Perm 327(67.3%) 15(75%) 0.6275
Retrieval Intent - Perm 159(32.7%) 5(25%)
Age (years) 64 (53, 71) 57 (49.8, 63.8) 0.114
Sex - Female 201(41.4%) 9(45%) 0.8184
Sex - Male 285(58.6%) 11(55%)
Clot Location - Calf 31(6.4%) 2(10%) 0.5183
Clot Location - Iliocaval 21(4.3%) 1(5%)
Clot Location - Iliocaval and pulmonary embolus 5(1%) 1(5%)
Clot Location - Leg 196(40.3%) 8(40%)
Clot Location - Leg and pulmonary embolus 111(22.8%) 3(15%)
Clot Location - Pulmonary embolus 115(23.7%) 5(25%)
Clot Location - Not applicable 7(1.4%) 0(0%)
Follow-up time (days) 52.5 (9.8, 193.5) 663 (218.5, 729) 0.009

Variable correlations with worsening clot

Table 2: Variables by worsening clot (WC) status.
Non-WC (N=456) WC (N=50) p-value
Hypercoagulable Disorder - No 440(96.5%) 48(96%) 0.6954
Hypercoagulable Disorder - Yes 16(3.5%) 2(4%)
Filter Indication - Anticoagulation Failure 39(8.6%) 4(8%) 0.667
Filter Indication - Calf DVT in neurosurgery patient 19(4.2%) 1(2%)
Filter Indication - DVT or PE with contraindication to anticoagulation 341(74.8%) 37(74%)
Filter Indication - Prophylactic 50(11%) 6(12%)
Filter Indication - Other 7(1.5%) 2(4%)
Dwell time (days) 106 (69.8, 154) 160 (76, 240.5) 0.018
Retrieval Intent - Non-perm 306(67.1%) 36(72%) 0.5281
Retrieval Attempted - Perm 150(32.9%) 14(28%)
Age (years) 64 (53, 71) 61 (50.2, 69) 0.204
Sex - Female 189(41.4%) 21(42%) 1
Sex - Male 267(58.6%) 29(58%)
Clot Location - Calf 28(6.1%) 5(10%) 0.3
Clot Location - Iliocaval 19(4.2%) 3(6%)
Clot Location - Iliocaval and pulmonary embolus 4(0.9%) 2(4%)
Clot Location - Leg 187(41%) 17(34%)
Clot Location - Leg and pulmonary embolus 104(22.8%) 10(20%)
Clot Location - Pulmonary embolus 108(23.7%) 12(24%)
Clot Location - Not applicable 6(1.3%) 1(2%)
Follow-up time (days) 56 (10.5, 226.2) 182 (165, 340) 0.153