Characteristic Overall, N = 114 G12D, N = 38 Other or wild, N = 76 p-value1
PD_L1_1, n (%)


0.3
    Negative 76 (67%) 23 (61%) 53 (70%)
    Positive 38 (33%) 15 (39%) 23 (30%)
PD_L1_2, n (%)


0.3
    Negative 82 (72%) 25 (66%) 57 (75%)
    Positive 32 (28%) 13 (34%) 19 (25%)
PD_L1_3, n (%)


0.5
    Negative 94 (82%) 30 (79%) 64 (84%)
    Positive 20 (18%) 8 (21%) 12 (16%)
Tumor purity, Mean (SD) 0.49 (0.19) 0.44 (0.17) 0.52 (0.20) 0.061
Gender, n (%)


0.7
     1 (0.9%) 0 (0%) 1 (1.3%)
    Female 38 (33%) 11 (29%) 27 (36%)
    Male 75 (66%) 27 (71%) 48 (63%)
Patient Age, Mean (SD) 60.08 (9.07) 61.84 (8.56) 59.20 (9.24) 0.2
TMB value, Mean (SD) 2.66 (2.16) 2.62 (1.57) 2.68 (2.42) 0.6
MSI score, Mean (SD) 7.73 (8.89) 8.48 (9.08) 7.35 (8.83) 0.5
KRAS_Type, n (%)


<0.001
    G12X 88 (77%) 38 (100%) 50 (66%)
    Other or wild 26 (23%) 0 (0%) 26 (34%)
HRR Mutation, n (%)


0.7
    0 97 (85%) 34 (89%) 63 (83%)
    6.666666667 15 (13%) 4 (11%) 11 (14%)
    13.33333333 2 (1.8%) 0 (0%) 2 (2.6%)
MMR Mutation, n (%)


0.5
    0 107 (94%) 35 (92%) 72 (95%)
    20 6 (5.3%) 2 (5.3%) 4 (5.3%)
    80 1 (0.9%) 1 (2.6%) 0 (0%)
HRR, n (%)


0.4
    Mut 17 (15%) 4 (11%) 13 (17%)
    Wild 97 (85%) 34 (89%) 63 (83%)
1 Pearson’s Chi-squared test; Wilcoxon rank sum test; Fisher’s exact test