| Compound 1 |
CDK4, ABL, FGFR1, FYN, KDR, LCK, LYN, SRC |
In vitro |
n.a. |
[41] |
| NBI1 |
CDK2 |
In vitro, cell lines HCT116, HT29, T98G, A2780, MDA-MB-468, SKBr3, MCF-7, A549, Jurkat, HL60 and Saos-2 |
colon carcinoma, glioblastoma, ovarian carcinoma, breast carcinoma, acute myeloid leukemia, lung carcinoma, osteosarcoma |
[47], [51] |
| Compound 530 |
CDK2, CDK4 |
In vitro |
n.a. |
[42] |
| F07#13 |
CDK2, CDK9 |
In vitro, mouse models |
AIDS |
[45] |
| 3α-Amino-5α-androstane |
CDK5 |
In vitro, Saccharomyces cerevisiae |
n.a. |
[36] |
| VMY-1-101 |
CDK2, CDK5, CDK7 |
In vitro, cell lines MDA-MB-231, MCF-7 |
breast carcinoma |
[50] |
| VMY-1-103 |
CDK2, CDK5, CDK7 |
In vitro, cell lines MDA-MB-231, MCF-7 |
breast carcinoma |
[50] |
| AMG 925 |
CDK4, FLT3 |
xenograft mouse model |
acute myeloid leukemia |
[38] |
| 7x |
CDK4, ARK5 |
In vitro, panel of human tumor cell lines, xenograft mouse model |
various human cancers (cell lines), breast carcinoma (mouse model) |
[37] |
| PD 0332991 |
CDK4, CDK6 |
mouse model |
brainstem glioma |
[52] |
| Flavopiridol |
CDK1, CDK2, CDK4, CDK7 |
xenograft mouse model |
glioma |
[53] |
| RGB-286638 |
pan-CDK |
xenograft mouse model |
multiple myeloma |
[49] |
| BAY 1000394 |
CDK1, CDK2, CDK3, CDK4, CDK7, CDK9 |
mouse model |
breast carcinoma |
[40] |
| Roscovitine |
CDK2, CDK5 |
mouse model |
radiation-induced salivary gland dysfunction, renal and hepatic cystogenesis, pain |
[54], [55], [57] |
| C8 |
CDK2, CDK5 |
mouse model |
renal and hepatic cystogenesis, traumatic brain injury |
[43], [55], [58] |
| AZD5438 |
CDK1, CDK2 |
xenograft mouse model |
non-small cell lung carcinoma |
[38] |
| P276 |
CDK4 |
xenograft mouse model |
pancreatic carcinoma |
[56] |