High (N=9)	Low (N=13)	P-value
Age
Mean (SD)	57.0 (12.2)	60.1 (6.02)	0.599
Median [Min, Max]	60.0 [34.0, 74.0]	59.0 [48.0, 69.0]
Gender
Female	4 (44.4%)	4 (30.8%)	0.838
Male	5 (55.6%)	9 (69.2%)
ECOG
0	4 (44.4%)	3 (23.1%)	0.554
1	5 (55.6%)	10 (76.9%)
Number.of.metastatic.site
>=2	6 (66.7%)	10 (76.9%)	0.965
0-1	3 (33.3%)	3 (23.1%)
Previous_immunotherapy
No	5 (55.6%)	7 (53.8%)	1
Yes	4 (44.4%)	6 (46.2%)
Lines.of.therapy
>=2	6 (66.7%)	8 (61.5%)	1
0-1	3 (33.3%)	5 (38.5%)
dNLR
<=3	7 (77.8%)	10 (76.9%)	1
>3	2 (22.2%)	3 (23.1%)
LDH
<=ULN	8 (88.9%)	5 (38.5%)	0.0543
>ULN	1 (11.1%)	8 (61.5%)
Albumin
<3.5 g/dL	1 (11.1%)	1 (7.7%)	1
>=3.5 g/dL	8 (88.9%)	12 (92.3%)
Liver.metastasis
no	8 (88.9%)	7 (53.8%)	0.204
yes	1 (11.1%)	6 (46.2%)
Previous_radiation_therapy
No	6 (66.7%)	10 (76.9%)	0.965
Yes	3 (33.3%)	3 (23.1%)
Smoking_history
No	6 (66.7%)	7 (53.8%)	0.873
Yes	3 (33.3%)	6 (46.2%)
BMI
Mean (SD)	23.7 (2.91)	23.4 (4.46)	0.337
Median [Min, Max]	24.1 [19.5, 28.4]	22.4 [17.0, 33.9]
ICI_response
PR	2 (22.2%)	1 (7.7%)	0.269
SD	6 (66.7%)	6 (46.2%)
PD	1 (11.1%)	5 (38.5%)
Missing	0 (0%)	1 (7.7%)