High (N=14)	Low (N=19)	P-value
Age
Mean (SD)	44.7 (8.50)	43.6 (9.19)	0.434
Median [Min, Max]	42.0 [32.0, 61.0]	40.0 [32.0, 64.0]
Gender
Female	3 (21.4%)	4 (21.1%)	1
Male	11 (78.6%)	15 (78.9%)
ECOG
0	6 (42.9%)	8 (42.1%)	1
1	8 (57.1%)	11 (57.9%)
Number.of.metastatic.site
>=2	13 (92.9%)	19 (100%)	0.876
0-1	1 (7.1%)	0 (0%)
Previous_immunotherapy
N	7 (50.0%)	8 (42.1%)	0.923
Y	7 (50.0%)	11 (57.9%)
Lines.of.therapy
>=2	12 (85.7%)	17 (89.5%)	1
0-1	2 (14.3%)	2 (10.5%)
dNLR
<=3	12 (85.7%)	14 (73.7%)	0.686
>3	2 (14.3%)	5 (26.3%)
LDH
<=ULN	7 (50.0%)	8 (42.1%)	0.923
>ULN	7 (50.0%)	11 (57.9%)
Albumin
<3.5 g/dL	0 (0%)	1 (5.3%)	1
>=3.5 g/dL	14 (100%)	18 (94.7%)
Liver.metastasis
no	8 (57.1%)	7 (36.8%)	0.421
yes	6 (42.9%)	12 (63.2%)
Previous_radiation_therapy
N	3 (21.4%)	2 (10.5%)	0.71
Y	11 (78.6%)	17 (89.5%)
Smoking_history
No	10 (71.4%)	16 (84.2%)	0.648
Yes	4 (28.6%)	3 (15.8%)
BMI
Mean (SD)	22.5 (2.98)	21.8 (2.75)	0.401
Median [Min, Max]	22.2 [18.6, 29.3]	21.9 [17.8, 29.0]
ICI_response
PR	6 (42.9%)	2 (10.5%)	0.031
SD	4 (28.6%)	2 (10.5%)
PD	4 (28.6%)	13 (68.4%)
Missing	0 (0%)	2 (10.5%)