High (N=15)	Low (N=18)	P-value
Age
Mean (SD)	41.0 (7.53)	46.6 (9.13)	0.531
Median [Min, Max]	39.0 [32.0, 58.0]	47.0 [32.0, 64.0]
Gender
Female	2 (13.3%)	5 (27.8%)	0.56
Male	13 (86.7%)	13 (72.2%)
ECOG
0	6 (40.0%)	8 (44.4%)	1
1	9 (60.0%)	10 (55.6%)
Number.of.metastatic.site
>=2	15 (100%)	17 (94.4%)	1
0-1	0 (0%)	1 (5.6%)
Previous_immunotherapy
N	7 (46.7%)	8 (44.4%)	1
Y	8 (53.3%)	10 (55.6%)
Lines.of.therapy
>=2	15 (100%)	14 (77.8%)	0.158
0-1	0 (0%)	4 (22.2%)
dNLR
<=3	12 (80.0%)	14 (77.8%)	1
>3	3 (20.0%)	4 (22.2%)
LDH
<=ULN	4 (26.7%)	11 (61.1%)	0.104
>ULN	11 (73.3%)	7 (38.9%)
Albumin
<3.5 g/dL	1 (6.7%)	0 (0%)	0.926
>=3.5 g/dL	14 (93.3%)	18 (100%)
Liver.metastasis
no	4 (26.7%)	11 (61.1%)	0.104
yes	11 (73.3%)	7 (38.9%)
Previous_radiation_therapy
N	1 (6.7%)	4 (22.2%)	0.451
Y	14 (93.3%)	14 (77.8%)
Smoking_history
No	14 (93.3%)	12 (66.7%)	0.15
Yes	1 (6.7%)	6 (33.3%)
BMI
Mean (SD)	21.9 (3.15)	22.2 (2.63)	0.399
Median [Min, Max]	21.9 [17.8, 29.0]	22.2 [18.1, 29.3]
ICI_response
PR	0 (0%)	8 (44.4%)	0.0015
SD	1 (6.7%)	5 (27.8%)
PD	12 (80.0%)	5 (27.8%)
Missing	2 (13.3%)	0 (0%)