DCB (N=13)	NDB (N=18)	P-value
Age
Mean (SD)	45.9 (9.58)	42.7 (8.55)	0.227
Median [Min, Max]	46.0 [32.0, 64.0]	40.0 [32.0, 61.0]
Gender
Female	4 (30.8%)	2 (11.1%)	0.365
Male	9 (69.2%)	16 (88.9%)
ECOG
0	4 (30.8%)	8 (44.4%)	0.691
1	9 (69.2%)	10 (55.6%)
Number.of.metastatic.site
>=2	12 (92.3%)	18 (100%)	0.868
0-1	1 (7.7%)	0 (0%)
Previous_immunotherapy
N	7 (53.8%)	7 (38.9%)	0.645
Y	6 (46.2%)	11 (61.1%)
Lines.of.therapy
>=2	9 (69.2%)	18 (100%)	0.0478
0-1	4 (30.8%)	0 (0%)
dNLR
<=3	11 (84.6%)	14 (77.8%)	0.988
>3	2 (15.4%)	4 (22.2%)
LDH
<=ULN	7 (53.8%)	7 (38.9%)	0.645
>ULN	6 (46.2%)	11 (61.1%)
Albumin
<3.5 g/dL	0 (0%)	0 (0%)	NA
>=3.5 g/dL	13 (100%)	18 (100%)
Liver.metastasis
no	8 (61.5%)	6 (33.3%)	0.233
yes	5 (38.5%)	12 (66.7%)
Previous_radiation_therapy
N	3 (23.1%)	2 (11.1%)	0.69
Y	10 (76.9%)	16 (88.9%)
Smoking_history
No	10 (76.9%)	14 (77.8%)	1
Yes	3 (23.1%)	4 (22.2%)
BMI
Mean (SD)	22.3 (3.08)	22.1 (2.84)	0.365
Median [Min, Max]	22.7 [18.1, 29.3]	22.1 [17.8, 29.0]
ICI_response
PR	8 (61.5%)	0 (0%)	<0.001
SD	5 (38.5%)	0 (0%)
PD	0 (0%)	17 (94.4%)
Missing	0 (0%)	1 (5.6%)