UK Twins Delta Gene Analysis

## [1]   142 25106

## 
##   concordant discordant_A discordant_B intermidiate 
##           47           22           40           33

Table_1: Bimodality Test

mclust Result

GmixR Result

LNmixR Result

Table_2: Contigency Table for Table_1

mclust

##          Dis_B_sig
## Dis_A_sig     0     1   Sum
##       0   19541  2641 22182
##       1    2513   411  2924
##       Sum 22054  3052 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 11.183, df = 4, p-value = 0.02458

##          Con_sig
## Dis_A_sig     0     1   Sum
##       0   19478  2704 22182
##       1    2506   418  2924
##       Sum 21984  3122 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 10.517, df = 4, p-value = 0.03256

##          Int_sig
## Dis_A_sig     0     1   Sum
##       0   19745  2437 22182
##       1    2468   456  2924
##       Sum 22213  2893 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 53.821, df = 4, p-value = 5.736e-11

##          Con_sig
## Dis_B_sig     0     1   Sum
##       0   19377  2677 22054
##       1    2607   445  3052
##       Sum 21984  3122 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 14.685, df = 4, p-value = 0.005401

##          Int_sig
## Dis_B_sig     0     1   Sum
##       0   19587  2467 22054
##       1    2626   426  3052
##       Sum 22213  2893 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 20.204, df = 4, p-value = 0.0004551

##        Int_sig
## Con_sig     0     1   Sum
##     0   19543  2441 21984
##     1    2670   452  3122
##     Sum 22213  2893 25106

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 30.531, df = 4, p-value = 3.815e-06

GmixR

##          Con_sig
## Dis_B_sig     0     1   Sum
##       0   18535  1335 19870
##       1    1298   133  1431
##       Sum 19833  1468 21301

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 13.799, df = 4, p-value = 0.007964

##          Int_sig
## Dis_B_sig     0     1   Sum
##       0   18411  1174 19585
##       1    1305   107  1412
##       Sum 19716  1281 20997

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 5.7649, df = 4, p-value = 0.2174

##        Int_sig
## Con_sig     0     1   Sum
##     0   18517  1190 19707
##     1    1356    99  1455
##     Sum 19873  1289 21162

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 1.3887, df = 4, p-value = 0.8462

LNmixR

##          Con_sig
## Dis_B_sig     0     1   Sum
##       0    5909  7008 12917
##       1    4866  5858 10724
##       Sum 10775 12866 23641

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 0.32524, df = 4, p-value = 0.9881

##          Int_sig
## Dis_B_sig     0     1   Sum
##       0    8286  4330 12616
##       1    6791  3702 10493
##       Sum 15077  8032 23109

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 2.3241, df = 4, p-value = 0.6764

##        Int_sig
## Con_sig     0     1   Sum
##     0    6982  3628 10610
##     1    8218  4478 12696
##     Sum 15200  8106 23306

## 
##  Pearson's Chi-squared test
## 
## data:  t
## X-squared = 2.9544, df = 4, p-value = 0.5655

Table_3: Bimodality Tests Results(All methods, overall data & by clusters)

Table_4: Test bimodality of delta overall data

These genes are filtered out as overall data bimodality tests show FDR < 0.01

Table_5: Test bimodality differences between clusters(Using KS Test)

Table_6: Agreement of methods across clusters(the number of methods that returned bimodality)