High (N=14)	Low (N=19)	P-value
Gender
Female	3 (21.4%)	4 (21.1%)	1
Male	11 (78.6%)	15 (78.9%)
Age (years)
Mean (SD)	44.7 (8.50)	43.6 (9.19)	0.434
Median [Min, Max]	42.0 [32.0, 61.0]	40.0 [32.0, 64.0]
Previous_immunotherapy
N	7 (50.0%)	8 (42.1%)	0.923
Y	7 (50.0%)	11 (57.9%)
Previous_radiation_therapy
N	3 (21.4%)	2 (10.5%)	0.71
Y	11 (78.6%)	17 (89.5%)
Smoking_history
No	10 (71.4%)	16 (84.2%)	0.648
Yes	4 (28.6%)	3 (15.8%)
BMI
Mean (SD)	22.5 (2.98)	21.8 (2.75)	0.401
Median [Min, Max]	22.2 [18.6, 29.3]	21.9 [17.8, 29.0]
ICI_response
PR	6 (42.9%)	2 (10.5%)	0.031
SD	4 (28.6%)	2 (10.5%)
PD	4 (28.6%)	13 (68.4%)
Missing	0 (0%)	2 (10.5%)