Dopo il preprocessamento dei dati sono state eliminate le seguenti
variabili avento un numero di missing values > 50%
|
Variable
|
Missing Values
|
|
48_months_creat
|
333 (100%)
|
|
60_months_creat
|
333 (100%)
|
|
10y_creat
|
333 (100%)
|
|
d_operated_kidney_volume_percent
|
332 (99.7%)
|
|
36_months_creat
|
332 (99.7%)
|
|
time_to_recurrence_months
|
331 (99.4%)
|
|
24_months_creat
|
326 (97.9%)
|
|
operated_kidney_preop_volume_cc
|
324 (97.3%)
|
|
lesions_volume_cc
|
321 (96.4%)
|
|
operated_kidney_postop_volume
|
321 (96.4%)
|
|
death
|
312 (93.7%)
|
|
site_of_recurrence
|
302 (90.7%)
|
|
treatment_of_recurrence
|
302 (90.7%)
|
|
crs_12_mesi
|
298 (89.5%)
|
|
date_of_last_crs
|
262 (78.7%)
|
|
3rd_month_postop_erpf
|
259 (77.8%)
|
|
d_erpf_percent
|
255 (76.6%)
|
|
crs_3_mesi
|
245 (73.6%)
|
|
last_crs
|
245 (73.6%)
|
|
recurrence
|
239 (71.8%)
|
|
3rd_month_postop_srf
|
227 (68.2%)
|
|
operated_kidney_preop_erpf
|
225 (67.6%)
|
|
time_last_follow_up
|
212 (63.7%)
|
|
3rd_month_complic
|
208 (62.5%)
|
|
delta_srf_percent
|
205 (61.6%)
|
|
resection
|
178 (53.5%)
|
|
operated_kidney_preop_srf
|
173 (52%)
|
|
margin_min_mm
|
171 (51.4%)
|
|
margin_max_mm
|
171 (51.4%)
|
Results
Di seguito la tabella con le caratteristiche ei pazienti arruolati
|
Variable
|
|
Missing Values
|
|
Age
|
63.86 ± 12.47
|
0 (0%)
|
|
Gender
|
|
0 (0%)
|
|
Gender (male)
|
229 (68.77%)
|
0 (0%)
|
|
female
|
104 (31.23%)
|
|
|
BMI
|
25.8 ± 4.24
|
43 (12.9%)
|
|
ECOG
|
|
10 (3%)
|
|
0
|
147 (44.14%)
|
|
|
1
|
151 (45.35%)
|
|
|
2
|
24 (7.21%)
|
|
|
3
|
1 (0.3%)
|
|
|
Hypertension
|
182 (54.65%)
|
10 (3%)
|
|
Diabetes
|
28 (8.41%)
|
9 (2.7%)
|
|
Smoking
|
70 (21.02%)
|
9 (2.7%)
|
|
Previous CVD
|
59 (17.72%)
|
9 (2.7%)
|
|
Charlson age-adj
|
3.85 ± 1.72
|
61 (18.3%)
|
|
ASA score
|
|
14 (4.2%)
|
|
ASA I
|
1 (0.3%)
|
|
|
ASA II
|
85 (25.53%)
|
|
|
ASA III
|
182 (54.65%)
|
|
|
ASA IV
|
51 (15.32%)
|
|
|
Solitary Kidney
|
15 (4.5%)
|
10 (3%)
|
|
Anatomical Abnormalities
|
0 (0%)
|
10 (3%)
|
|
Symptoms
|
|
12 (3.6%)
|
|
absent
|
283 (84.98%)
|
|
|
local
|
38 (11.41%)
|
|
|
systemic
|
0 (0%)
|
|
|
Side
|
|
11 (3.3%)
|
|
right
|
164 (49.25%)
|
|
|
left
|
158 (47.45%)
|
|
|
Face
|
|
66 (19.8%)
|
|
anterior
|
148 (44.44%)
|
|
|
posterior
|
119 (35.74%)
|
|
|
Polar location
|
|
22 (6.6%)
|
|
upper
|
91 (27.33%)
|
|
|
middle
|
131 (39.34%)
|
|
|
inferior
|
89 (26.73%)
|
|
|
Lesion’s size (clinical, mm)
|
39.23 ± 16.49
|
42 (12.6%)
|
|
cystic features
|
|
11 (3.3%)
|
|
solid (not cystic)
|
273 (81.98%)
|
|
|
cystic
|
49 (14.71%)
|
|
|
margin features
|
|
11 (3.3%)
|
|
regular (pseudocapsula present)
|
307 (92.19%)
|
|
|
irregular (no pseudocapsula)
|
15 (4.5%)
|
|
|
vascular anatomy
|
|
44 (13.2%)
|
|
regular
|
263 (78.98%)
|
|
|
double renal artery
|
11 (3.3%)
|
|
|
feading artery
|
15 (4.5%)
|
|
|
cT
|
|
12 (3.6%)
|
|
T1a
|
184 (55.26%)
|
|
|
T1b
|
120 (36.04%)
|
|
|
T2a
|
17 (5.11%)
|
|
|
cN
|
|
12 (3.6%)
|
|
N0
|
320 (96.1%)
|
|
|
N1
|
1 (0.3%)
|
|
|
M
|
2 (0.6%)
|
12 (3.6%)
|
|
Polar score
|
|
20 (6%)
|
|
upper/inferior
|
172 (51.65%)
|
|
|
middle
|
141 (42.34%)
|
|
|
Rim location
|
|
22 (6.6%)
|
|
lateral
|
190 (57.06%)
|
|
|
medial
|
121 (36.34%)
|
|
|
Renal sinus
|
|
24 (7.2%)
|
|
not involved
|
239 (71.77%)
|
|
|
involved
|
70 (21.02%)
|
|
|
UCS invasion
|
|
26 (7.8%)
|
|
not involved
|
241 (72.37%)
|
|
|
involved
|
66 (19.82%)
|
|
|
Esophytic rate
|
|
20 (6%)
|
|
>=50%
|
145 (43.54%)
|
|
|
< 50%
|
125 (37.54%)
|
|
|
endophytic
|
43 (12.91%)
|
|
|
clinical size category
|
|
17 (5.1%)
|
|
until 4 cm
|
181 (54.35%)
|
|
|
4.1-7 cm
|
117 (35.14%)
|
|
|
>7 cm
|
18 (5.41%)
|
|
|
PADUA score
|
8 (7-10)
|
17 (5.1%)
|
|
PADUA risk category
|
|
18 (5.4%)
|
|
6-7
|
108 (32.43%)
|
|
|
8-9
|
123 (36.94%)
|
|
|
>=10
|
84 (25.23%)
|
|
|
Radius
|
|
19 (5.7%)
|
|
<4 cm
|
180 (54.05%)
|
|
|
4-7 cm
|
116 (34.83%)
|
|
|
>7 cm
|
18 (5.41%)
|
|
|
Exophytic/endophytic properties
|
|
22 (6.6%)
|
|
>50%
|
141 (42.34%)
|
|
|
<50%
|
129 (38.74%)
|
|
|
entirely endophytic
|
41 (12.31%)
|
|
|
Nearness to the UCS or sinus
|
|
29 (8.7%)
|
|
>=7
|
84 (25.23%)
|
|
|
5-6
|
111 (33.33%)
|
|
|
<=4
|
109 (32.73%)
|
|
|
Anterior/posterior
|
|
37 (11.1%)
|
|
a
|
154 (46.25%)
|
|
|
p
|
126 (37.84%)
|
|
|
x
|
16 (4.8%)
|
|
|
Location relative to the polar line
|
|
28 (8.4%)
|
|
1
|
129 (38.74%)
|
|
|
2
|
104 (31.23%)
|
|
|
3
|
71 (21.32%)
|
|
|
4
|
1 (0.3%)
|
|
|
RENAL nephrometry score
|
6.97 ± 2
|
19 (5.7%)
|
|
preop Hb
|
14.29 ± 1.55
|
46 (13.8%)
|
|
postop Hb
|
12.16 ± 1.62
|
50 (15%)
|
|
preop Ht
|
44.32 ± 5.14
|
50 (15%)
|
|
postop Ht
|
37.16 ± 5.37
|
50 (15%)
|
|
glucosio preop
|
102.34 ± 33.26
|
48 (14.4%)
|
|
glucosio postop
|
100.57 ± 30.36
|
51 (15.3%)
|
|
preop creat
|
0.98 ± 0.41
|
0 (0%)
|
|
postop Creat
|
1.15 ± 0.57
|
0 (0%)
|
|
preop MDRD eGFR
|
83.2 ± 26.11
|
0 (0%)
|
|
postop MDRD eGFR
|
72.71 ± 27.01
|
0 (0%)
|
|
Lap Approach
|
|
8 (2.4%)
|
|
pure laparoscopic
|
86 (25.83%)
|
|
|
robot-assisted
|
238 (71.47%)
|
|
|
open
|
1 (0.3%)
|
|
|
Access
|
|
9 (2.7%)
|
|
transperitoneal
|
240 (72.07%)
|
|
|
retroperitoneal
|
84 (25.23%)
|
|
|
Operative Time (min)
|
94.44 ± 38.28
|
10 (3%)
|
|
Management of Renal Artery
|
|
8 (2.4%)
|
|
clampless
|
55 (16.52%)
|
|
|
global ischemia
|
132 (39.64%)
|
|
|
selective ischemia
|
135 (40.54%)
|
|
|
early unclamping
|
3 (0.9%)
|
|
|
Type of Ischemia
|
|
60 (18%)
|
|
warm ischemia
|
266 (79.88%)
|
|
|
cold ischemia
|
7 (2.1%)
|
|
|
ischemia time, min
|
18.2 ± 7.98
|
63 (18.9%)
|
|
Fluorescence
|
96 (28.83%)
|
16 (4.8%)
|
|
US
|
36 (10.81%)
|
14 (4.2%)
|
|
opening of UCS
|
62 (18.62%)
|
0 (0%)
|
|
Suture of renal defect
|
|
1 (0.3%)
|
|
single-layer
|
160 (48.05%)
|
|
|
double-layer
|
172 (51.65%)
|
|
|
Use of Floseal/Surgiflo
|
251 (75.38%)
|
10 (3%)
|
|
Use of Tachosil
|
96 (28.83%)
|
18 (5.4%)
|
|
Blood loss, mL
|
187.18 ± 192.79
|
19 (5.7%)
|
|
Intraop transf
|
4 (1.2%)
|
11 (3.3%)
|
|
Intraop compl
|
4 (1.2%)
|
10 (3%)
|
|
conversion to open surgery
|
0 (0%)
|
10 (3%)
|
|
conversion to radical nephrectomy
|
1 (0.3%)
|
29 (8.7%)
|
|
postoperative complications
|
43 (12.91%)
|
50 (15%)
|
|
type of compl
|
|
50 (15%)
|
|
no compl
|
240 (72.07%)
|
|
|
post-op bleeding
|
14 (4.2%)
|
|
|
perirenal hematoma
|
1 (0.3%)
|
|
|
urine leakage
|
1 (0.3%)
|
|
|
fever
|
6 (1.8%)
|
|
|
pneumonia
|
7 (2.1%)
|
|
|
other
|
14 (4.2%)
|
|
|
Clavien grade
|
|
152 (45.6%)
|
|
grade 0
|
134 (40.24%)
|
|
|
grade 1
|
26 (7.81%)
|
|
|
grade 2
|
19 (5.71%)
|
|
|
grade 3
|
1 (0.3%)
|
|
|
grade 4
|
1 (0.3%)
|
|
|
Treatment
|
|
184 (55.3%)
|
|
No specific action
|
106 (31.83%)
|
|
|
Medical therapy
|
21 (6.31%)
|
|
|
Blood transfusion
|
20 (6.01%)
|
|
|
Hembolization
|
1 (0.3%)
|
|
|
Surgical procedure
|
1 (0.3%)
|
|
|
Length of Stay, days
|
6 (5-7)
|
115 (34.5%)
|
|
…96
|
3 (0.9%)
|
131 (39.3%)
|
|
Lesion’s size (AP, mm)
|
38.61 ± 17.08
|
39 (11.7%)
|
|
Malignant?
|
234 (70.27%)
|
38 (11.4%)
|
|
Histotype if malignant
|
|
99 (29.7%)
|
|
clear cell
|
156 (46.85%)
|
|
|
papillary
|
47 (14.11%)
|
|
|
chromophobe
|
25 (7.51%)
|
|
|
unclassified
|
2 (0.6%)
|
|
|
other
|
4 (1.2%)
|
|
|
Histotype if Benign
|
|
269 (80.8%)
|
|
oncocytoma
|
38 (11.41%)
|
|
|
angiomyolipoma
|
16 (4.8%)
|
|
|
benign cyst
|
6 (1.8%)
|
|
|
others
|
4 (1.2%)
|
|
|
ISUP Grade
|
|
100 (30%)
|
|
grade 1
|
39 (11.71%)
|
|
|
grade 2
|
121 (36.34%)
|
|
|
grade 3
|
41 (12.31%)
|
|
|
grade 4
|
1 (0.3%)
|
|
|
not applicable
|
31 (9.31%)
|
|
|
necrosis
|
68 (20.42%)
|
75 (22.5%)
|
|
Surgical margins
|
|
75 (22.5%)
|
|
negative
|
248 (74.47%)
|
|
|
positive
|
10 (3%)
|
|
|
pT
|
|
62 (18.6%)
|
|
benign
|
30 (9.01%)
|
|
|
pT1a
|
120 (36.04%)
|
|
|
pT1b
|
74 (22.22%)
|
|
|
pT2
|
9 (2.7%)
|
|
|
pT3a
|
37 (11.11%)
|
|
|
pT3b
|
1 (0.3%)
|
|
|
MIC score
|
|
107 (32.1%)
|
|
0
|
173 (51.95%)
|
|
|
1
|
53 (15.92%)
|
|