Objective

Perform real world data analysis using BifurcatoR tools to check bimodality

Table 1

Table 1. UK Twins Characteristics (N= 624)
Variable N = 6241
Cluster
    cluster4 62 (9.9%)
    cluster3 193 (31%)
    cluster2 260 (42%)
    cluster1 109 (17%)
HDAC_signature 0.0 (1.0)
IGN1_exp 0.0 (1.0)
NNAT_adipo_exp 2.2 (0.1)
Insulin 3.7 (0.6)
Lean_mass 39.8 (5.4)
Fat_mass 27.9 (8.9)
BMI 26.6 (4.8)
Obesity
    normal 505 (81%)
    obese 78 (13%)
    severe_obese 41 (6.6%)
AGE 60.3 (9.0)
SEX
    F 624 (100%)
Zygosity
    Dizygotic 431 (69%)
    Monozygotic 193 (31%)
HEIGHT 161.4 (5.8)
WEIGHT 69.3 (13.6)
Lean Mass Index 15.2 (1.7)
Fat Mass Index 10.7 (3.3)
1 n (%); Mean (SD)

NNAT (All Samples)

NNAT (Cluster_1 + Cluster_2 + Cluster_3 + Cluster_4)

NNAT (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of NNAT using Ameijeiras-Alonso et al. Excess Mass Fit is: 0.236"
Bimodality Coefficient
##      cl_1_2_twins$NNAT_adipo_exp
## [1,]                       FALSE
## [1] "Bimodality Coefficient of NNAT is: 0.34, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of NNAT using Cheng and Hall Excess Mass is: 0.224"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of NNAT using Fisher and Marron Carmer-von Mises is: 0.747"
Hall and York Bandwidth test
## [1] "Bimodality P-value of NNAT using Hall and York Bandwidth test is: 0.769"
Hartigans’ dip test
## [1] "Bimodality P-value of NNAT using Hartigans' dip test is: 0.79"
Sliverman Bandwidth
## [1] "Bimodality P-value of NNAT using Sliverman Bandwidth is: 0.891"

HDAC (All Samples)

HDAC (Cluster_1 + Cluster_2 + Cluster_3 + Cluster_4)

HDAC (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of HDAC using Ameijeiras-Alonso et al. Excess Mass Fit is: 0.461"
Bimodality Coefficient
##      cl_1_2_twins$HDAC_signature
## [1,]                       FALSE
## [1] "Bimodality Coefficient of HDAC is: 0.42, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of HDAC using Cheng and Hall Excess Mass is: 0.52"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of HDAC using Fisher and Marron Carmer-von Mises is: 0.398"
Hall and York Bandwidth test
## [1] "Bimodality P-value of HDAC using Hall and York Bandwidth test is: 0.396"
Hartigans’ dip test
## [1] "Bimodality P-value of HDAC using Hartigans' dip test is: 0.953"
Sliverman Bandwidth
## [1] "Bimodality P-value of HDAC using Sliverman Bandwidth is: 0.548"

PGA3

PGA3 (Cluster_1 + Cluster_2 + Cluster_3 + Cluster_4)

PGA3 (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of PGA3 using Ameijeiras-Alonso et al. Excess Mass Fit is: 0"
Bimodality Coefficient
##      pga_c1_c2$value
## [1,]           FALSE
## [1] "Bimodality Coefficient of PGA3 is: 0.42, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of PGA3 using Cheng and Hall Excess Mass is: 0"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of PGA3 using Fisher and Marron Carmer-von Mises is: 0.05"
Hall and York Bandwidth test
## [1] "Bimodality P-value of PGA3 using Hall and York Bandwidth test is: 0.036"
Hartigans’ dip test
## [1] "Bimodality P-value of PGA3 using Hartigans' dip test is: 0.019"
Sliverman Bandwidth
## [1] "Bimodality P-value of PGA3 using Sliverman Bandwidth is: 0.274"