Objective

Perform real world data analysis using BifurcatoR tools to check bimodality

Table 1

Table 1. UK Twins Characteristics (N= 369)
Variable N = 3691
Cluster
    cluster1 109 (30%)
    cluster2 260 (70%)
HDAC_signature 0.6 (0.6)
IGN1_exp -0.3 (0.9)
NNAT_adipo_exp 2.2 (0.1)
Insulin 4.0 (0.6)
Lean_mass 41.1 (5.7)
Fat_mass 31.5 (8.7)
BMI 28.4 (4.8)
Obesity
    normal 259 (70%)
    obese 70 (19%)
    severe_obese 40 (11%)
AGE 61.1 (8.0)
SEX
    F 369 (100%)
Zygosity
    Dizygotic 258 (70%)
    Monozygotic 111 (30%)
HEIGHT 161.6 (5.7)
WEIGHT 74.3 (13.8)
Lean Mass Index 15.7 (1.8)
Fat Mass Index 12.1 (3.2)
1 n (%); Mean (SD)

NNAT (All Samples)

NNAT (Cluster_1 + Cluster_2 + Cluster_3 + Cluster_4)

NNAT (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of NNAT using Ameijeiras-Alonso et al. Excess Mass Fit is: 0.24"
Bimodality Coefficient
##       nnat
## [1,] FALSE
## [1] "Bimodality Coefficient of NNAT is: 0.34, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of NNAT using Cheng and Hall Excess Mass is: 0.237"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of NNAT using Fisher and Marron Carmer-von Mises is: 0.746"
Hall and York Bandwidth test
## [1] "Bimodality P-value of NNAT using Hall and York Bandwidth test is: 0.753"
Hartigans’ dip test
## [1] "Bimodality P-value of NNAT using Hartigans' dip test is: 0.778"
Sliverman Bandwidth
## [1] "Bimodality P-value of NNAT using Sliverman Bandwidth is: 0.891"

HDAC (All Samples)

HDAC (Cluster_1 + Cluster_2 + Cluster_3 + Cluster_4)

HDAC (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of HDAC using Ameijeiras-Alonso et al. Excess Mass Fit is: 0.456"
Bimodality Coefficient
##      sub_twins$HDAC_signature
## [1,]                    FALSE
## [1] "Bimodality Coefficient of HDAC is: 0.42, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of HDAC using Cheng and Hall Excess Mass is: 0.502"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of HDAC using Fisher and Marron Carmer-von Mises is: 0.419"
Hall and York Bandwidth test
## [1] "Bimodality P-value of HDAC using Hall and York Bandwidth test is: 0.412"
Hartigans’ dip test
## [1] "Bimodality P-value of HDAC using Hartigans' dip test is: 0.956"
Sliverman Bandwidth
## [1] "Bimodality P-value of HDAC using Sliverman Bandwidth is: 0.562"

PGA3

PGA3 (Cluster_1 + Cluster_2)

Ameijeiras-Alonso et al. Excess Mass Fit
## [1] "Bimodality P-value of PGA3 using Ameijeiras-Alonso et al. Excess Mass Fit is: 0"
Bimodality Coefficient
##      sub_m_c1_c2$value
## [1,]             FALSE
## [1] "Bimodality Coefficient of PGA3 is: 0.42, which is less than 0.555, so no bimodality detected."
Cheng and Hall Excess Mass
## [1] "Bimodality P-value of PGA3 using Cheng and Hall Excess Mass is: 0.001"
Fisher and Marron Carmer-von Mises
## [1] "Bimodality P-value of PGA3 using Fisher and Marron Carmer-von Mises is: 0.032"
Hall and York Bandwidth test
## [1] "Bimodality P-value of PGA3 using Hall and York Bandwidth test is: 0.028"
Hartigans’ dip test
## [1] "Bimodality P-value of PGA3 using Hartigans' dip test is: 0.017"
Sliverman Bandwidth
## [1] "Bimodality P-value of PGA3 using Sliverman Bandwidth is: 0.298"