Statistical analysis

Changes in lab values across days 0, 7, and 28 were visualized by line plots and compared by the repeated measures ANOVA test. All statistical analyses were performed using R (version 4.0.2, R Foundation for Statistical Computing, Vienna, Austria). A \(p\)-value <0.05 was considered statistically significant.

Results

Line plots showing animal-level (IDs = 3851, 3852, 3853, and 3854) changes in lab values across days 0, 7, and 28 are plotted below. The p-values for testing those changes are tabulated in Table 1. In summary, eGFR, HCT, Bicarbonate, Sodium, and weight change significantly over time (HGB and BUN borderline significantly).

Table 1. Repeated measures ANOVA comparing days 0, 7, and 28.
p-value
eGFR <0.001
HGB 0.082
HCT 0.042
BUN 0.112
Creatinine 0.625
Bicarbonate 0.024
Chloride 0.453
Potassium 0.482
Sodium 0.014
Weight 0.001