SIS

Remove all objects from workspace.

remove (list = objects() ) 

Load add-on packages - deSolve - contains lsoda function - differential equation solver.

library (deSolve)

## 
## Attaching package: 'deSolve'
## 
## The following object is masked from 'package:graphics':
## 
##     matplot

Function to compute derivatives of the differential equations.

sis_model = function (current_timepoint, state_values, parameters)
{  
  # create state variables (local variables)
  S = state_values [1]        # susceptibles
  I = state_values [2]        # infectious
  
  with (
    as.list (parameters), # variable names within parameters can be used 
         { # compute derivatives
           dS = (-beta * S * I) + (gamma * I)
           dI = ( beta * S * I) - (gamma * I)
           
           
           # combine results
           results = c (dS, dI)
           list (results)
         } 
        )
}

Parameters

contact_rate = 10                 # number of contacts per day
transmission_probability = 0.07   # transmission probability
infectious_period = 5             # infectious period

Compute values of beta (tranmission rate) and gamma (recovery rate).

beta_value = contact_rate * transmission_probability
gamma_value = 1 / infectious_period

Compute Ro - Reproductive number.

Ro = beta_value / gamma_value

Disease dynamics parameters.

parameter_list = c (beta = beta_value, gamma = gamma_value)

Initial values for sub-populations.

X = 9999        # susceptible hosts
Y = 1           # infectious hosts
Z = 0           # recovered hosts

Compute total population.

N = X + Y + Z

Initial state values for the differential equations.

initial_values = c (S = X/N, I = Y/N)

Output timepoints.

timepoints = seq (0, 50, by=1)

Simulate the SIS epidemic.

output = lsoda (initial_values, timepoints, sis_model, parameter_list)

Plot dynamics of Susceptibles sub-population.

plot (S ~ time, data = output, type='b', col = 'blue') 

Plot dynamics of Infectious sub-population.

plot (I ~ time, data = output, type='b', col = 'red')

Plot dynamics of Susceptibles, Infectious and Recovered sub-populations in the same plot.

# susceptible hosts over time
plot (S ~ time, data = output, type='b', ylim = c(0,1), col = 'blue', ylab = 'S, I, S', main = 'SIS epidemic') 
text(30,0.2, "S", col = 'blue')

# remain on same frame
par (new = TRUE)    

# infectious hosts over time
plot (I ~ time, data = output, type='b', ylim = c(0,1), col = 'red', ylab = '', axes = FALSE) 
text(30,0.8, "I", col = 'red')

# remain on same frame
par (new = TRUE)  

Description: This infectious disease model has only two (2) compartments which are susceptible (S) and infected(I). The disease dynamic is moving between susceptible and infected stage. Since this disease dynamic does not develop to recovery or resistant stage, infected hosts could get reinfetion again, for example, rotavirus, and salmonellosis.