Smoke Exposure and COVID-19 in California

Author

Thomas McHale

[[1]]
[1] "dplyr"     "stats"     "graphics"  "grDevices" "utils"     "datasets" 
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[[5]]
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[[7]]
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[11] "utils"      "datasets"   "methods"    "base"      

[[8]]
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[[9]]
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[[11]]
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[16] "datasets"   "methods"    "base"      

[[12]]
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[13] "stats"         "graphics"      "grDevices"     "utils"        
[17] "datasets"      "methods"       "base"         

[[13]]
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[10] "tidycensus"        "tidyr"             "stringr"          
[13] "dplyr"             "stats"             "graphics"         
[16] "grDevices"         "utils"             "datasets"         
[19] "methods"           "base"             

[[14]]
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[10] "ggmap"             "mapdata"           "maps"             
[13] "scales"            "ggplot2"           "sf"               
[16] "tidycensus"        "tidyr"             "stringr"          
[19] "dplyr"             "stats"             "graphics"         
[22] "grDevices"         "utils"             "datasets"         
[25] "methods"           "base"             

[[15]]
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[10] "ggspatial"         "ggmap"             "mapdata"          
[13] "maps"              "scales"            "ggplot2"          
[16] "sf"                "tidycensus"        "tidyr"            
[19] "stringr"           "dplyr"             "stats"            
[22] "graphics"          "grDevices"         "utils"            
[25] "datasets"          "methods"           "base"             

[[16]]
 [1] "plotly"            "tigris"            "lubridate"        
 [4] "forcats"           "purrr"             "readr"            
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[10] "rnaturalearth"     "ggspatial"         "ggmap"            
[13] "mapdata"           "maps"              "scales"           
[16] "ggplot2"           "sf"                "tidycensus"       
[19] "tidyr"             "stringr"           "dplyr"            
[22] "stats"             "graphics"          "grDevices"        
[25] "utils"             "datasets"          "methods"          
[28] "base"             

[[17]]
 [1] "mapproj"           "plotly"            "tigris"           
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[10] "rnaturalearthdata" "rnaturalearth"     "ggspatial"        
[13] "ggmap"             "mapdata"           "maps"             
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[25] "grDevices"         "utils"             "datasets"         
[28] "methods"           "base"             

[[18]]
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[10] "tidyverse"         "rnaturalearthdata" "rnaturalearth"    
[13] "ggspatial"         "ggmap"             "mapdata"          
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[22] "stringr"           "dplyr"             "stats"            
[25] "graphics"          "grDevices"         "utils"            
[28] "datasets"          "methods"           "base"             

[[19]]
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[10] "tibble"            "tidyverse"         "rnaturalearthdata"
[13] "rnaturalearth"     "ggspatial"         "ggmap"            
[16] "mapdata"           "maps"              "scales"           
[19] "ggplot2"           "sf"                "tidycensus"       
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[25] "stats"             "graphics"          "grDevices"        
[28] "utils"             "datasets"          "methods"          
[31] "base"             

[[20]]
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[10] "readr"             "tibble"            "tidyverse"        
[13] "rnaturalearthdata" "rnaturalearth"     "ggspatial"        
[16] "ggmap"             "mapdata"           "maps"             
[19] "scales"            "ggplot2"           "sf"               
[22] "tidycensus"        "tidyr"             "stringr"          
[25] "dplyr"             "stats"             "graphics"         
[28] "grDevices"         "utils"             "datasets"         
[31] "methods"           "base"             

[[21]]
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[10] "purrr"             "readr"             "tibble"           
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[16] "ggspatial"         "ggmap"             "mapdata"          
[19] "maps"              "scales"            "ggplot2"          
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[25] "stringr"           "dplyr"             "stats"            
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[31] "datasets"          "methods"           "base"             

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[19] "ggmap"             "mapdata"           "maps"             
[22] "scales"            "ggplot2"           "sf"               
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[22] "ggmap"             "mapdata"           "maps"             
[25] "scales"            "ggplot2"           "sf"               
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[31] "dplyr"             "stats"             "graphics"         
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[[27]]
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[43] "methods"           "base"             

[[31]]
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[16] "ggtext"            "mapproj"           "plotly"           
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[28] "ggspatial"         "ggmap"             "mapdata"          
[31] "maps"              "scales"            "ggplot2"          
[34] "sf"                "tidycensus"        "tidyr"            
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Reading layer `ca_smoke_monthly' from data source 
  `/Users/thomasmchale/Desktop/Wildfire-fungi-project/repository/smoke-infections/shapefiles/ca_smoke_monthly.shp' 
  using driver `ESRI Shapefile'
Simple feature collection with 580 features and 12 fields
Geometry type: MULTIPOLYGON
Dimension:     XY
Bounding box:  xmin: -124.4096 ymin: 32.5342 xmax: -114.1344 ymax: 42.00952
Geodetic CRS:  WGS 84

Interactive Exploration of Association between Smoke Exposure and COVID-19 in 2020

Please navigate to the link in order to explore the incidence of COVID-19 cases and deaths for each month of 2020 as well as the smoke exposure for particulate matter (PM) of 2.5 µm in California in 2020.

You can select each month of 2020 for COVID-19 cases and deaths and it will display the incidence per 10,000 persons for each county for that month. Below the COVID-19 map is an interactive map of smoke exposure. This displays the PM 2.5 µm smoke exposure in each county of California in 2020. You can pick each month to display to correspond to the COVID-19 maps.

Since the influence and timing of smoke exposure leading to a respiratory infection is not clear, this lets you interact with different time points between smoke exposure and COVID-19. For example, if there is an incubation period between smoke exposure that lasts several weeks or months you can look at COVID-19 months after the smoke exposure. This might be expected if smoke exposure causes lung injury that pre-disposes individuals to an increased risk of COVID-19

View the Shiny app

Smoke PM 2.5 Exposure in 2020

COVID-19 Cases in 2020

Smoke PM 2.5 Exposure in 2021

COVID-19 Cases in 2021

Smoke PM 2.5 Exposure in 2022

COVID-19 Cases in 2022

Explore the Associations of Population and Demographic Data

Population Map

According to the American Community Survey (ACS) data, California had an estimated population of over 39 million in 2020, making it the most populous state in the United States. The population is diverse, with individuals from various ethnic and racial backgrounds. About 60% of the population resides in urban areas, with the largest cities being Los Angeles, San Diego, and San Jose. The median household income is $80,440. The education level is diverse, with approximately 31% of the population holding a bachelor’s degree or higher. The follwoing map shows the population of each county on a log base 10 scale. You can hover over each county to view additional demographic data.

Note

Click on a specific county to display population and demographic information. You can zoom in and out with the buttons in the top left corner or scrolling with your mouse.

leaflet

Demographic Maps

Median Income

<iframe src="~/Desktop/Wildfire-fungi-project/repository/smoke-infections/images/cal_income_map.html" width="100%" height="400"></iframe>

Rate of Workers Predominantly Outdoors

Since smoke is likely to affect workers who spend most of their time outdoors, I wanted to look at the rate of outdoor laborers in California. The variables used to determine outdoor laborers compared to all laborers were “B24011_031” and “B24011_034” from the ACS data. These two variables represent the number of workers 16 years and over who worked in farming, fishing, and forestry occupations, specifically those who worked on a farm, ranch, or in an orchard (B24011_031) or those who worked in other farming, fishing, and forestry occupations (B24011_034). These two variables were selected and summed to calculate the total number of outdoor laborers per county. The total number of laborers per county was also calculated by summing all the variables starting with “B24011”. The outdoor laborer rate was then determined by dividing the total number of outdoor laborers by the total number of laborers in each county, and multiplying by 100 to express it as a percentage.

<iframe src="~/Desktop/Wildfire-fungi-project/repository/smoke-infections/images/cal_labor_map.html" width="100%" height="400"></iframe>

Mask Use Survey

This data was taken from the New York Times github COVID-19 page. I am displaying the percent of persons who rated “ALWAYS” wearing a mask, since this was the most common survey response. The other responses can be seen in the label when you hover over the county.

Specifically from the READme.md description at https://github.com/nytimes/covid-19-data/tree/master/mask-use:
“This data comes from a large number of interviews conducted online by the global data and survey firm Dynata at the request of The New York Times. The firm asked a question about mask use to obtain 250,000 survey responses between July 2 and July 14, enough data to provide estimates more detailed than the state level. (Several states have imposed new mask requirements since the completion of these interviews.)

Specifically, each participant was asked: How often do you wear a mask in public when you expect to be within six feet of another person?

This survey was conducted a single time, and at this point we have no plans to update the data or conduct the survey again.”

<iframe src="~/Desktop/Wildfire-fungi-project/repository/smoke-infections/images/cal_mask_map.html" width="100%" height="400"></iframe>

Environmental Maps

Temperature

<iframe src="~/Desktop/Wildfire-fungi-project/repository/smoke-infections/images/cal_temp_map.html" width="100%" height="400"></iframe>

Elevation

<iframe src="~/Desktop/Wildfire-fungi-project/repository/smoke-infections/images/cal_elevation_map.html" width="100%" height="400"></iframe>

Statistical Analysis of Smoke Association with COVID-19 Cases Lagged 1, 2, and 3 Months

2020

Univariate Linear Mixed Effects Modelling

Cases

Treating Smoke as Continuous

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
smoke                                     21.667**                                                                     -10.005                                                   -31.839***     
                                          (9.157)                                                                      (8.538)                                                     (7.942)      
                                                                                                                                                                                                
Constant                                2,438.098***                                                                2,364.625***                                                2,217.425***    
                                         (300.106)                                                                    (267.070)                                                   (233.356)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                445                                                                          387                                                         329        
Log Likelihood                           -4,236.572                                                                  -3,639.831                                                  -3,038.862     
Akaike Inf. Crit.                        8,481.145                                                                    7,287.662                                                   6,085.723     
Bayesian Inf. Crit.                      8,497.537                                                                    7,303.496                                                   6,100.908     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "smoke                                     21.667**                                                                     -10.005                                                   -31.839***     "
[11] "                                          (9.157)                                                                      (8.538)                                                     (7.942)      "
[12] "                                                                                                                                                                                                "
[13] "Constant                                2,438.098***                                                                2,364.625***                                                2,217.425***    "
[14] "                                         (300.106)                                                                    (267.070)                                                   (233.356)     "
[15] "                                                                                                                                                                                                "
[16] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[17] "Observations                                445                                                                          387                                                         329        "
[18] "Log Likelihood                           -4,236.572                                                                  -3,639.831                                                  -3,038.862     "
[19] "Akaike Inf. Crit.                        8,481.145                                                                    7,287.662                                                   6,085.723     "
[20] "Bayesian Inf. Crit.                      8,497.537                                                                    7,303.496                                                   6,100.908     "
[21] "================================================================================================================================================================================================"
[22] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"
Treating Smoke as a Factor

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
smoke_factormedium                      4,193.437***                                                                3,349.888***                                                1,930.195***    
                                         (324.390)                                                                    (321.159)                                                   (321.996)     
                                                                                                                                                                                                
smoke_factorhigh                        2,014.235***                                                                  776.078**                                                   -407.447      
                                         (304.788)                                                                    (302.038)                                                   (309.255)     
                                                                                                                                                                                                
Constant                                1,042.642***                                                                1,012.593***                                                1,228.575***    
                                         (311.837)                                                                    (286.178)                                                   (269.799)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                445                                                                          387                                                         329        
Log Likelihood                           -4,158.725                                                                  -3,581.901                                                  -3,009.133     
Akaike Inf. Crit.                        8,327.449                                                                    7,173.802                                                   6,028.266     
Bayesian Inf. Crit.                      8,347.940                                                                    7,193.594                                                   6,047.246     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "smoke_factormedium                      4,193.437***                                                                3,349.888***                                                1,930.195***    "
[11] "                                         (324.390)                                                                    (321.159)                                                   (321.996)     "
[12] "                                                                                                                                                                                                "
[13] "smoke_factorhigh                        2,014.235***                                                                  776.078**                                                   -407.447      "
[14] "                                         (304.788)                                                                    (302.038)                                                   (309.255)     "
[15] "                                                                                                                                                                                                "
[16] "Constant                                1,042.642***                                                                1,012.593***                                                1,228.575***    "
[17] "                                         (311.837)                                                                    (286.178)                                                   (269.799)     "
[18] "                                                                                                                                                                                                "
[19] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[20] "Observations                                445                                                                          387                                                         329        "
[21] "Log Likelihood                           -4,158.725                                                                  -3,581.901                                                  -3,009.133     "
[22] "Akaike Inf. Crit.                        8,327.449                                                                    7,173.802                                                   6,028.266     "
[23] "Bayesian Inf. Crit.                      8,347.940                                                                    7,193.594                                                   6,047.246     "
[24] "================================================================================================================================================================================================"
[25] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"

Deaths


Linear Regression Results
=========================================================================
                                     Dependent variable:                 
                    -----------------------------------------------------
                                     death_incidence_1mo                 
                    Model 1: Smoke as Continuous Model 2: Smoke as Factor
                                (1)                        (2)           
-------------------------------------------------------------------------
smoke                          0.248                                     
                              (0.166)                                    
                                                                         
smoke_factormedium                                      59.815***        
                                                         (6.292)         
                                                                         
smoke_factorhigh                                        26.701***        
                                                         (5.912)         
                                                                         
Constant                     36.837***                  16.729***        
                              (6.279)                    (6.475)         
                                                                         
-------------------------------------------------------------------------
Observations                    445                        445           
Log Likelihood               -2,466.519                 -2,420.209       
Akaike Inf. Crit.            4,941.038                  4,850.418        
Bayesian Inf. Crit.          4,957.430                  4,870.908        
=========================================================================
Note:                                         *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                         
 [2] "Linear Regression Results"                                                
 [3] "========================================================================="
 [4] "                                     Dependent variable:                 "
 [5] "                    -----------------------------------------------------"
 [6] "                                     death_incidence_1mo                 "
 [7] "                    Model 1: Smoke as Continuous Model 2: Smoke as Factor"
 [8] "                                (1)                        (2)           "
 [9] "-------------------------------------------------------------------------"
[10] "smoke                          0.248                                     "
[11] "                              (0.166)                                    "
[12] "                                                                         "
[13] "smoke_factormedium                                      59.815***        "
[14] "                                                         (6.292)         "
[15] "                                                                         "
[16] "smoke_factorhigh                                        26.701***        "
[17] "                                                         (5.912)         "
[18] "                                                                         "
[19] "Constant                     36.837***                  16.729***        "
[20] "                              (6.279)                    (6.475)         "
[21] "                                                                         "
[22] "-------------------------------------------------------------------------"
[23] "Observations                    445                        445           "
[24] "Log Likelihood               -2,466.519                 -2,420.209       "
[25] "Akaike Inf. Crit.            4,941.038                  4,850.418        "
[26] "Bayesian Inf. Crit.          4,957.430                  4,870.908        "
[27] "========================================================================="
[28] "Note:                                         *p<0.1; **p<0.05; ***p<0.01"

Multivariate Linear Mixed Effects Modelling


Linear Regression Results
======================================================================
                                    Dependent variable:               
                     -------------------------------------------------
                       covid_incidence_1mo      death_incidence_1mo   
                     Model 1: Covid Incidence Model 2: Death Incidence
                               (1)                      (2)           
----------------------------------------------------------------------
smoke_factormedium         4,275.531***              61.458***        
                            (323.096)                 (6.257)         
                                                                      
smoke_factorhigh           2,089.776***              28.586***        
                            (305.155)                 (5.906)         
                                                                      
median_income                -0.033**                -0.001***        
                             (0.013)                  (0.0003)        
                                                                      
outdoor_laborer_rate          10.914                   -0.324         
                             (68.100)                 (1.371)         
                                                                      
avg_temp                    128.480***                3.747***        
                             (45.904)                 (0.926)         
                                                                      
precip                     -103.270***                 -0.942         
                             (29.079)                 (0.586)         
                                                                      
ALWAYS                      -2,985.037                 83.083         
                           (2,966.741)                (59.867)        
                                                                      
NEVER                      -14,877.440*               -208.414        
                           (8,964.591)               (181.000)        
                                                                      
Constant                     -530.722                -180.690**       
                           (4,322.027)                (87.150)        
                                                                      
----------------------------------------------------------------------
Observations                   445                      445           
Log Likelihood              -4,109.255               -2,391.205       
Akaike Inf. Crit.           8,240.511                4,804.410        
Bayesian Inf. Crit.         8,285.590                4,849.489        
======================================================================
Note:                                      *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                      
 [2] "Linear Regression Results"                                             
 [3] "======================================================================"
 [4] "                                    Dependent variable:               "
 [5] "                     -------------------------------------------------"
 [6] "                       covid_incidence_1mo      death_incidence_1mo   "
 [7] "                     Model 1: Covid Incidence Model 2: Death Incidence"
 [8] "                               (1)                      (2)           "
 [9] "----------------------------------------------------------------------"
[10] "smoke_factormedium         4,275.531***              61.458***        "
[11] "                            (323.096)                 (6.257)         "
[12] "                                                                      "
[13] "smoke_factorhigh           2,089.776***              28.586***        "
[14] "                            (305.155)                 (5.906)         "
[15] "                                                                      "
[16] "median_income                -0.033**                -0.001***        "
[17] "                             (0.013)                  (0.0003)        "
[18] "                                                                      "
[19] "outdoor_laborer_rate          10.914                   -0.324         "
[20] "                             (68.100)                 (1.371)         "
[21] "                                                                      "
[22] "avg_temp                    128.480***                3.747***        "
[23] "                             (45.904)                 (0.926)         "
[24] "                                                                      "
[25] "precip                     -103.270***                 -0.942         "
[26] "                             (29.079)                 (0.586)         "
[27] "                                                                      "
[28] "ALWAYS                      -2,985.037                 83.083         "
[29] "                           (2,966.741)                (59.867)        "
[30] "                                                                      "
[31] "NEVER                      -14,877.440*               -208.414        "
[32] "                           (8,964.591)               (181.000)        "
[33] "                                                                      "
[34] "Constant                     -530.722                -180.690**       "
[35] "                           (4,322.027)                (87.150)        "
[36] "                                                                      "
[37] "----------------------------------------------------------------------"
[38] "Observations                   445                      445           "
[39] "Log Likelihood              -4,109.255               -2,391.205       "
[40] "Akaike Inf. Crit.           8,240.511                4,804.410        "
[41] "Bayesian Inf. Crit.         8,285.590                4,849.489        "
[42] "======================================================================"
[43] "Note:                                      *p<0.1; **p<0.05; ***p<0.01"

2021

Univariate Linear Mixed Effects Modelling

Cases

Treating Smoke Exposre as Continuous

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
monthly_avg_smoke                          1.163                                                                        0.761                                                       0.367       
                                          (3.917)                                                                      (4.040)                                                     (4.184)      
                                                                                                                                                                                                
Constant                                 858.045***                                                                  833.423***                                                  811.434***     
                                          (91.754)                                                                    (96.104)                                                    (101.590)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                829                                                                          778                                                         727        
Log Likelihood                           -7,254.277                                                                  -6,829.339                                                  -6,403.257     
Akaike Inf. Crit.                        14,516.550                                                                  13,666.680                                                  12,814.510     
Bayesian Inf. Crit.                      14,535.430                                                                  13,685.300                                                  12,832.870     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "monthly_avg_smoke                          1.163                                                                        0.761                                                       0.367       "
[11] "                                          (3.917)                                                                      (4.040)                                                     (4.184)      "
[12] "                                                                                                                                                                                                "
[13] "Constant                                 858.045***                                                                  833.423***                                                  811.434***     "
[14] "                                          (91.754)                                                                    (96.104)                                                    (101.590)     "
[15] "                                                                                                                                                                                                "
[16] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[17] "Observations                                829                                                                          778                                                         727        "
[18] "Log Likelihood                           -7,254.277                                                                  -6,829.339                                                  -6,403.257     "
[19] "Akaike Inf. Crit.                        14,516.550                                                                  13,666.680                                                  12,814.510     "
[20] "Bayesian Inf. Crit.                      14,535.430                                                                  13,685.300                                                  12,832.870     "
[21] "================================================================================================================================================================================================"
[22] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"
Treating Smoke Exposure as a Factor

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
smoke_factormedium                         29.503                                                                       0.823                                                      -25.654      
                                         (143.613)                                                                    (153.548)                                                   (165.941)     
                                                                                                                                                                                                
smoke_factorhigh                          175.466                                                                      127.883                                                     83.288       
                                         (203.119)                                                                    (213.432)                                                   (224.754)     
                                                                                                                                                                                                
Constant                                 828.814***                                                                  824.898***                                                  821.874***     
                                         (140.566)                                                                    (149.991)                                                   (162.014)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                829                                                                          778                                                         727        
Log Likelihood                           -7,244.233                                                                  -6,819.359                                                  -6,393.270     
Akaike Inf. Crit.                        14,498.470                                                                  13,648.720                                                  12,796.540     
Bayesian Inf. Crit.                      14,522.070                                                                  13,672.000                                                  12,819.490     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "smoke_factormedium                         29.503                                                                       0.823                                                      -25.654      "
[11] "                                         (143.613)                                                                    (153.548)                                                   (165.941)     "
[12] "                                                                                                                                                                                                "
[13] "smoke_factorhigh                          175.466                                                                      127.883                                                     83.288       "
[14] "                                         (203.119)                                                                    (213.432)                                                   (224.754)     "
[15] "                                                                                                                                                                                                "
[16] "Constant                                 828.814***                                                                  824.898***                                                  821.874***     "
[17] "                                         (140.566)                                                                    (149.991)                                                   (162.014)     "
[18] "                                                                                                                                                                                                "
[19] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[20] "Observations                                829                                                                          778                                                         727        "
[21] "Log Likelihood                           -7,244.233                                                                  -6,819.359                                                  -6,393.270     "
[22] "Akaike Inf. Crit.                        14,498.470                                                                  13,648.720                                                  12,796.540     "
[23] "Bayesian Inf. Crit.                      14,522.070                                                                  13,672.000                                                  12,819.490     "
[24] "================================================================================================================================================================================================"
[25] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"

Deaths


Linear Regression Results
=========================================================================
                                     Dependent variable:                 
                    -----------------------------------------------------
                                     death_incidence_1mo                 
                    Model 1: Smoke as Continuous Model 2: Smoke as Factor
                                (1)                        (2)           
-------------------------------------------------------------------------
monthly_avg_smoke              0.021                                     
                              (0.068)                                    
                                                                         
smoke_factormedium                                        0.618          
                                                         (2.496)         
                                                                         
smoke_factorhigh                                          2.124          
                                                         (3.525)         
                                                                         
Constant                     11.668***                  11.205***        
                              (1.628)                    (2.469)         
                                                                         
-------------------------------------------------------------------------
Observations                    829                        829           
Log Likelihood               -3,900.754                 -3,894.999       
Akaike Inf. Crit.            7,809.508                  7,799.999        
Bayesian Inf. Crit.          7,828.389                  7,823.600        
=========================================================================
Note:                                         *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                         
 [2] "Linear Regression Results"                                                
 [3] "========================================================================="
 [4] "                                     Dependent variable:                 "
 [5] "                    -----------------------------------------------------"
 [6] "                                     death_incidence_1mo                 "
 [7] "                    Model 1: Smoke as Continuous Model 2: Smoke as Factor"
 [8] "                                (1)                        (2)           "
 [9] "-------------------------------------------------------------------------"
[10] "monthly_avg_smoke              0.021                                     "
[11] "                              (0.068)                                    "
[12] "                                                                         "
[13] "smoke_factormedium                                        0.618          "
[14] "                                                         (2.496)         "
[15] "                                                                         "
[16] "smoke_factorhigh                                          2.124          "
[17] "                                                         (3.525)         "
[18] "                                                                         "
[19] "Constant                     11.668***                  11.205***        "
[20] "                              (1.628)                    (2.469)         "
[21] "                                                                         "
[22] "-------------------------------------------------------------------------"
[23] "Observations                    829                        829           "
[24] "Log Likelihood               -3,900.754                 -3,894.999       "
[25] "Akaike Inf. Crit.            7,809.508                  7,799.999        "
[26] "Bayesian Inf. Crit.          7,828.389                  7,823.600        "
[27] "========================================================================="
[28] "Note:                                         *p<0.1; **p<0.05; ***p<0.01"

Multivarirate Linear Mixed Regression Modelling


Linear Mixed Effects Regression Results
========================================================================
                                      Dependent variable:               
                       -------------------------------------------------
                         covid_incidence_1mo      death_incidence_1mo   
                       Model 1: Covid Incidence Model 2: Death Incidence
                                 (1)                      (2)           
------------------------------------------------------------------------
smoke_factormedium             -28.166                   -0.438         
                              (146.803)                 (2.544)         
                                                                        
smoke_factorhigh                75.814                   0.566          
                              (205.164)                 (3.554)         
                                                                        
median_income.x                 -0.007                  -0.0001         
                               (0.005)                  (0.0001)        
                                                                        
outdoor_laborer_rate.x          13.022                   0.359          
                               (25.539)                 (0.451)         
                                                                        
avg_temp                        21.058                   0.765*         
                               (23.167)                 (0.407)         
                                                                        
precip                          -9.158                   -0.050         
                               (7.618)                  (0.134)         
                                                                        
Constant                       -32.344                  -34.781         
                             (2,002.354)                (35.209)        
                                                                        
------------------------------------------------------------------------
Observations                     829                      829           
Log Likelihood                -7,233.113               -3,898.968       
Akaike Inf. Crit.             14,484.230               7,815.935        
Bayesian Inf. Crit.           14,526.710               7,858.417        
========================================================================
Note:                                        *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                        
 [2] "Linear Mixed Effects Regression Results"                                 
 [3] "========================================================================"
 [4] "                                      Dependent variable:               "
 [5] "                       -------------------------------------------------"
 [6] "                         covid_incidence_1mo      death_incidence_1mo   "
 [7] "                       Model 1: Covid Incidence Model 2: Death Incidence"
 [8] "                                 (1)                      (2)           "
 [9] "------------------------------------------------------------------------"
[10] "smoke_factormedium             -28.166                   -0.438         "
[11] "                              (146.803)                 (2.544)         "
[12] "                                                                        "
[13] "smoke_factorhigh                75.814                   0.566          "
[14] "                              (205.164)                 (3.554)         "
[15] "                                                                        "
[16] "median_income.x                 -0.007                  -0.0001         "
[17] "                               (0.005)                  (0.0001)        "
[18] "                                                                        "
[19] "outdoor_laborer_rate.x          13.022                   0.359          "
[20] "                               (25.539)                 (0.451)         "
[21] "                                                                        "
[22] "avg_temp                        21.058                   0.765*         "
[23] "                               (23.167)                 (0.407)         "
[24] "                                                                        "
[25] "precip                          -9.158                   -0.050         "
[26] "                               (7.618)                  (0.134)         "
[27] "                                                                        "
[28] "Constant                       -32.344                  -34.781         "
[29] "                             (2,002.354)                (35.209)        "
[30] "                                                                        "
[31] "------------------------------------------------------------------------"
[32] "Observations                     829                      829           "
[33] "Log Likelihood                -7,233.113               -3,898.968       "
[34] "Akaike Inf. Crit.             14,484.230               7,815.935        "
[35] "Bayesian Inf. Crit.           14,526.710               7,858.417        "
[36] "========================================================================"
[37] "Note:                                        *p<0.1; **p<0.05; ***p<0.01"

2022

Univariate Linear Mixed Effects Modelling

Cases

Treating Smoke Exposure as Continuous

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
monthly_avg_smoke                          11.587                                                                      17.477                                                      15.672       
                                          (30.828)                                                                    (32.757)                                                    (34.091)      
                                                                                                                                                                                                
Constant                                2,155.184***                                                                2,081.134***                                                2,063.747***    
                                         (300.173)                                                                    (314.647)                                                   (332.164)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                822                                                                          772                                                         722        
Log Likelihood                           -7,875.747                                                                  -7,418.487                                                  -6,959.760     
Akaike Inf. Crit.                        15,759.500                                                                  14,844.980                                                  13,927.520     
Bayesian Inf. Crit.                      15,778.340                                                                  14,863.570                                                  13,945.850     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "monthly_avg_smoke                          11.587                                                                      17.477                                                      15.672       "
[11] "                                          (30.828)                                                                    (32.757)                                                    (34.091)      "
[12] "                                                                                                                                                                                                "
[13] "Constant                                2,155.184***                                                                2,081.134***                                                2,063.747***    "
[14] "                                         (300.173)                                                                    (314.647)                                                   (332.164)     "
[15] "                                                                                                                                                                                                "
[16] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[17] "Observations                                822                                                                          772                                                         722        "
[18] "Log Likelihood                           -7,875.747                                                                  -7,418.487                                                  -6,959.760     "
[19] "Akaike Inf. Crit.                        15,759.500                                                                  14,844.980                                                  13,927.520     "
[20] "Bayesian Inf. Crit.                      15,778.340                                                                  14,863.570                                                  13,945.850     "
[21] "================================================================================================================================================================================================"
[22] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"
Treating Smoke Exposure as a Factor

Linear Mixed Effect Regression Results
================================================================================================================================================================================================
                                                                                                Dependent variable:                                                                             
                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo
                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    
                                            (1)                                                                          (2)                                                         (3)        
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
smoke_factormedium                         57.022                                                                      44.887                                                      45.266       
                                         (312.804)                                                                    (330.687)                                                   (352.249)     
                                                                                                                                                                                                
smoke_factorhigh                          219.669                                                                      286.961                                                     240.915      
                                         (787.735)                                                                    (857.508)                                                   (889.195)     
                                                                                                                                                                                                
Constant                                2,194.760***                                                                2,170.068***                                                2,141.637***    
                                         (297.050)                                                                    (311.932)                                                   (331.031)     
                                                                                                                                                                                                
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Observations                                822                                                                          772                                                         722        
Log Likelihood                           -7,865.914                                                                  -7,408.629                                                  -6,949.827     
Akaike Inf. Crit.                        15,741.830                                                                  14,827.260                                                  13,909.650     
Bayesian Inf. Crit.                      15,765.390                                                                  14,850.500                                                  13,932.560     
================================================================================================================================================================================================
Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                                                                                                                                                
 [2] "Linear Mixed Effect Regression Results"                                                                                                                                                          
 [3] "================================================================================================================================================================================================"
 [4] "                                                                                                Dependent variable:                                                                             "
 [5] "                    ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
 [6] "                                    covid_incidence_1mo                                                          covid_incidence_2mo                                         covid_incidence_3mo"
 [7] "                    Model 1: Case Incidence 1 Month After Smoke Exposure Model 2: Case Incidence 2 Months After Smoke Exposure, Case Incidence 3 Months After Smoke Exposure                    "
 [8] "                                            (1)                                                                          (2)                                                         (3)        "
 [9] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[10] "smoke_factormedium                         57.022                                                                      44.887                                                      45.266       "
[11] "                                         (312.804)                                                                    (330.687)                                                   (352.249)     "
[12] "                                                                                                                                                                                                "
[13] "smoke_factorhigh                          219.669                                                                      286.961                                                     240.915      "
[14] "                                         (787.735)                                                                    (857.508)                                                   (889.195)     "
[15] "                                                                                                                                                                                                "
[16] "Constant                                2,194.760***                                                                2,170.068***                                                2,141.637***    "
[17] "                                         (297.050)                                                                    (311.932)                                                   (331.031)     "
[18] "                                                                                                                                                                                                "
[19] "------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------"
[20] "Observations                                822                                                                          772                                                         722        "
[21] "Log Likelihood                           -7,865.914                                                                  -7,408.629                                                  -6,949.827     "
[22] "Akaike Inf. Crit.                        15,741.830                                                                  14,827.260                                                  13,909.650     "
[23] "Bayesian Inf. Crit.                      15,765.390                                                                  14,850.500                                                  13,932.560     "
[24] "================================================================================================================================================================================================"
[25] "Note:                                                                                                                                                                *p<0.1; **p<0.05; ***p<0.01"

Deaths

Multivariate Linear Mixed Regression Modelling


Linear Regression Results
======================================================================
                                    Dependent variable:               
                     -------------------------------------------------
                       covid_incidence_1mo      death_incidence_1mo   
                     Model 1: Covid Incidence Model 2: Death Incidence
                               (1)                      (2)           
----------------------------------------------------------------------
smoke_factormedium            13.270                   -1.198         
                            (317.380)                 (3.950)         
                                                                      
smoke_factorhigh              75.784                   -0.698         
                            (788.890)                 (9.802)         
                                                                      
median_income                 -0.012                  -0.0002         
                             (0.011)                  (0.0001)        
                                                                      
outdoor_laborer_rate          37.530                   0.840          
                             (58.450)                 (0.750)         
                                                                      
avg_temp                      6.716                    0.849          
                             (52.465)                 (0.668)         
                                                                      
precip                       -31.591                   -0.092         
                             (23.170)                 (0.296)         
                                                                      
Constant                    2,240.051                 -33.084         
                           (4,534.186)                (57.859)        
                                                                      
----------------------------------------------------------------------
Observations                   822                      822           
Log Likelihood              -7,852.854               -4,275.390       
Akaike Inf. Crit.           15,723.710               8,568.779        
Bayesian Inf. Crit.         15,766.110               8,611.185        
======================================================================
Note:                                      *p<0.1; **p<0.05; ***p<0.01
 [1] ""                                                                      
 [2] "Linear Regression Results"                                             
 [3] "======================================================================"
 [4] "                                    Dependent variable:               "
 [5] "                     -------------------------------------------------"
 [6] "                       covid_incidence_1mo      death_incidence_1mo   "
 [7] "                     Model 1: Covid Incidence Model 2: Death Incidence"
 [8] "                               (1)                      (2)           "
 [9] "----------------------------------------------------------------------"
[10] "smoke_factormedium            13.270                   -1.198         "
[11] "                            (317.380)                 (3.950)         "
[12] "                                                                      "
[13] "smoke_factorhigh              75.784                   -0.698         "
[14] "                            (788.890)                 (9.802)         "
[15] "                                                                      "
[16] "median_income                 -0.012                  -0.0002         "
[17] "                             (0.011)                  (0.0001)        "
[18] "                                                                      "
[19] "outdoor_laborer_rate          37.530                   0.840          "
[20] "                             (58.450)                 (0.750)         "
[21] "                                                                      "
[22] "avg_temp                      6.716                    0.849          "
[23] "                             (52.465)                 (0.668)         "
[24] "                                                                      "
[25] "precip                       -31.591                   -0.092         "
[26] "                             (23.170)                 (0.296)         "
[27] "                                                                      "
[28] "Constant                    2,240.051                 -33.084         "
[29] "                           (4,534.186)                (57.859)        "
[30] "                                                                      "
[31] "----------------------------------------------------------------------"
[32] "Observations                   822                      822           "
[33] "Log Likelihood              -7,852.854               -4,275.390       "
[34] "Akaike Inf. Crit.           15,723.710               8,568.779        "
[35] "Bayesian Inf. Crit.         15,766.110               8,611.185        "
[36] "======================================================================"
[37] "Note:                                      *p<0.1; **p<0.05; ***p<0.01"