Results FI_affirmo Cum Events 1y

Deficits’ proportion

Mortality FI (stratified by train)

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0 1
n 101521 101521
DEF_Anemia = 1 (%) 13886 (13.7) 13965 (13.8)
DEF_Blood_blood_forming_organ_dis = 1 (%) 4841 ( 4.8) 4941 ( 4.9)
DEF_Cardiac_valve_dis = 1 (%) 14190 (14.0) 13998 (13.8)
DEF_Cerebrovascular_dis = 1 (%) 19007 (18.7) 19001 (18.7)
DEF_Chronic_kidney_dis = 1 (%) 7469 ( 7.4) 7495 ( 7.4)
DEF_Chronic_pancr_bil_gall_dis = 1 (%) 3039 ( 3.0) 2986 ( 2.9)
DEF_Chronic_ulcer_of_the_skin = 1 (%) 4451 ( 4.4) 4324 ( 4.3)
DEF_Colitis_related_dis = 1 (%) 20540 (20.2) 20618 (20.3)
DEF_COPD_emphy_chron_bronchitis = 1 (%) 9711 ( 9.6) 9711 ( 9.6)
DEF_Dementia = 1 (%) 6234 ( 6.1) 6180 ( 6.1)
DEF_Depression = 1 (%) 4098 ( 4.0) 4046 ( 4.0)
DEF_Dorsopathies = 1 (%) 7357 ( 7.2) 7465 ( 7.4)
DEF_Epilepsy = 1 (%) 2086 ( 2.1) 2077 ( 2.0)
DEF_Esophagus_stomach_duodenum_dis = 1 (%) 6570 ( 6.5) 6454 ( 6.4)
DEF_Heart_failure = 1 (%) 32758 (32.3) 32430 (31.9)
DEF_Inflammatory_arthropathies = 1 (%) 8596 ( 8.5) 8502 ( 8.4)
DEF_Neurotic_stress_somatoform_dis = 1 (%) 3266 ( 3.2) 3330 ( 3.3)
DEF_Obesity = 1 (%) 3779 ( 3.7) 3868 ( 3.8)
DEF_Other_metabolic_dis = 1 (%) 3738 ( 3.7) 3723 ( 3.7)
DEF_Other_neurological_dis = 1 (%) 5599 ( 5.5) 5695 ( 5.6)
DEF_Other_psychia_behavioral_dis = 1 (%) 5029 ( 5.0) 5139 ( 5.1)
DEF_Parkinson_parkinsonism = 1 (%) 2386 ( 2.4) 2313 ( 2.3)
DEF_Peripheral_vascular_dis = 1 (%) 4041 ( 4.0) 4213 ( 4.1)
DEF_Solid_neoplasms = 1 (%) 23350 (23.0) 23157 (22.8)
DEF_polypharmacy = 1 (%) 33945 (33.4) 34073 (33.6)
DEF_civil_cat = 1 (%) 52914 (52.1) 52776 (52.0)
DEF_income_cat = 1 (%) 60323 (59.4) 60905 (60.0)

Hospitalization FI (stratified by train)

0 1
n 101521 101521
DEF_Anemia = 1 (%) 13886 (13.7) 13965 (13.8)
DEF_Asthma = 1 (%) 5341 ( 5.3) 5463 ( 5.4)
DEF_Autoimmune_dis = 1 (%) 6723 ( 6.6) 6966 ( 6.9)
DEF_Blood_blood_forming_organ_dis = 1 (%) 4841 ( 4.8) 4941 ( 4.9)
DEF_Cardiac_valve_dis = 1 (%) 14190 (14.0) 13998 (13.8)
DEF_Cerebrovascular_dis = 1 (%) 19007 (18.7) 19001 (18.7)
DEF_Chronic_kidney_dis = 1 (%) 7469 ( 7.4) 7495 ( 7.4)
DEF_Chronic_pancr_bil_gall_dis = 1 (%) 3039 ( 3.0) 2986 ( 2.9)
DEF_Chronic_ulcer_of_the_skin = 1 (%) 4451 ( 4.4) 4324 ( 4.3)
DEF_Colitis_related_dis = 1 (%) 20540 (20.2) 20618 (20.3)
DEF_COPD_emphy_chron_bronchitis = 1 (%) 9711 ( 9.6) 9711 ( 9.6)
DEF_Deafness_hearing_loss = 1 (%) 6970 ( 6.9) 6839 ( 6.7)
DEF_Depression = 1 (%) 4098 ( 4.0) 4046 ( 4.0)
DEF_Diabetes = 1 (%) 21354 (21.0) 21393 (21.1)
DEF_Epilepsy = 1 (%) 2086 ( 2.1) 2077 ( 2.0)
DEF_Esophagus_stomach_duodenum_dis = 1 (%) 6570 ( 6.5) 6454 ( 6.4)
DEF_Heart_failure = 1 (%) 32758 (32.3) 32430 (31.9)
DEF_Hypertension = 1 (%) 69202 (68.2) 69223 (68.2)
DEF_Inflammatory_arthropathies = 1 (%) 8596 ( 8.5) 8502 ( 8.4)
DEF_Ischemic_heart_dis = 1 (%) 31223 (30.8) 30975 (30.5)
DEF_Neurotic_stress_somatoform_dis = 1 (%) 3266 ( 3.2) 3330 ( 3.3)
DEF_Obesity = 1 (%) 3779 ( 3.7) 3868 ( 3.8)
DEF_Osteoarthritis = 1 (%) 15371 (15.1) 15175 (14.9)
DEF_Other_cardiovascular_dis = 1 (%) 15950 (15.7) 16064 (15.8)
DEF_Other_eye_dis = 1 (%) 23265 (22.9) 23315 (23.0)
DEF_Other_genitourinary_dis = 1 (%) 10421 (10.3) 10231 (10.1)
DEF_Other_metabolic_dis = 1 (%) 3738 ( 3.7) 3723 ( 3.7)
DEF_Other_neurological_dis = 1 (%) 5599 ( 5.5) 5695 ( 5.6)
DEF_Other_psychia_behavioral_dis = 1 (%) 5029 ( 5.0) 5139 ( 5.1)
DEF_Parkinson_parkinsonism = 1 (%) 2386 ( 2.4) 2313 ( 2.3)
DEF_Peripheral_neuropathy = 1 (%) 4104 ( 4.0) 4163 ( 4.1)
DEF_Peripheral_vascular_dis = 1 (%) 4041 ( 4.0) 4213 ( 4.1)
DEF_Prostate_dis = 1 (%) 11176 (11.0) 10950 (10.8)
DEF_Sleep_dis = 1 (%) 4741 ( 4.7) 4909 ( 4.8)
DEF_Solid_neoplasms = 1 (%) 23350 (23.0) 23157 (22.8)
DEF_Thyroid_dis = 1 (%) 12094 (11.9) 12272 (12.1)
DEF_Venous_lymphatic_dis = 1 (%) 3378 ( 3.3) 3347 ( 3.3)
DEF_polypharmacy = 1 (%) 33945 (33.4) 34073 (33.6)

#Most selected deficits Mortality

                        DEF_Asthma  DEF_Blood_blood_forming_organ_dis 
                                21                                 20 
                     DEF_education              DEF_Cardiac_valve_dis 
                                19                                 18 
           DEF_Colitis_related_dis    DEF_COPD_emphy_chron_bronchitis 
                                18                                 18 
                        DEF_Anemia              DEF_Cataract_lens_dis 
                                17                                 17 
           DEF_Cerebrovascular_dis                   DEF_Dyslipidemia 
                                17                                 17 
   DEF_Bradycardias_conduction_dis                       DEF_Dementia 
                                16                                 16 
                    DEF_Depression DEF_Neurotic_stress_somatoform_dis 
                                16                                 16 
                DEF_Osteoarthritis                 DEF_Autoimmune_dis 
                                16                                 15 
            DEF_Chronic_kidney_dis      DEF_Chronic_ulcer_of_the_skin 
                                15                                 15 
         DEF_Deafness_hearing_loss                       DEF_Diabetes 
                                15                                 15 
DEF_Esophagus_stomach_duodenum_dis                  DEF_Heart_failure 
                                15                                 15 
    DEF_Inflammatory_arthropathies                  DEF_Other_eye_dis 
                                15                                 15 
        DEF_Other_neurological_dis         DEF_Parkinson_parkinsonism 
                                15                                 15 
       DEF_Peripheral_vascular_dis           DEF_Venous_lymphatic_dis 
                                15                                 15 
                     DEF_civil_cat     DEF_Chronic_pancr_bil_gall_dis 
                                15                                 14 
           DEF_Ear_nose_throat_dis            DEF_Other_metabolic_dis 
                                14                                 14 
                     DEF_Sleep_dis                   DEF_Dorsopathies 
                                14                                 13 
      DEF_Other_cardiovascular_dis        DEF_Other_genitourinary_dis 
                                13                                 13 
                      DEF_Epilepsy                       DEF_Glaucoma 
                                12                                 12 
                  DEF_Hypertension             DEF_Ischemic_heart_dis 
                                12                                 12 
                       DEF_Obesity                   DEF_Osteoporosis 
                                12                                 12 
                     DEF_Other_MSK                   DEF_Prostate_dis 
                                12                                 12 
                   DEF_Thyroid_dis   DEF_Other_psychia_behavioral_dis 
                                12                                 11 
         DEF_Peripheral_neuropathy                DEF_Solid_neoplasms 
                                11                                 11 
                    DEF_income_cat                   DEF_polypharmacy 
                                11                                 10 

#Most selected deficits Hospitalization

                        DEF_Asthma  DEF_Blood_blood_forming_organ_dis 
                                15                                 15 
             DEF_Cardiac_valve_dis            DEF_Cerebrovascular_dis 
                                14                                 14 
            DEF_Chronic_kidney_dis            DEF_Ear_nose_throat_dis 
                                14                                 14 
            DEF_Ischemic_heart_dis                      DEF_Other_MSK 
                                14                                 14 
        DEF_Parkinson_parkinsonism                         DEF_Anemia 
                                14                                 13 
         DEF_Deafness_hearing_loss                       DEF_Diabetes 
                                13                                 13 
DEF_Esophagus_stomach_duodenum_dis                       DEF_Glaucoma 
                                13                                 13 
    DEF_Inflammatory_arthropathies                        DEF_Obesity 
                                13                                 13 
                 DEF_Other_eye_dis   DEF_Other_psychia_behavioral_dis 
                                13                                 13 
       DEF_Peripheral_vascular_dis                   DEF_Prostate_dis 
                                13                                 13 
                     DEF_Sleep_dis                    DEF_Thyroid_dis 
                                13                                 13 
                  DEF_polypharmacy                     DEF_income_cat 
                                13                                 13 
                     DEF_education                 DEF_Autoimmune_dis 
                                12                                 12 
   DEF_Bradycardias_conduction_dis              DEF_Cataract_lens_dis 
                                12                                 12 
    DEF_Chronic_pancr_bil_gall_dis      DEF_Chronic_ulcer_of_the_skin 
                                12                                 12 
                    DEF_Depression                   DEF_Dyslipidemia 
                                12                                 12 
                 DEF_Heart_failure                   DEF_Hypertension 
                                12                                 12 
                  DEF_Osteoporosis            DEF_Other_metabolic_dis 
                                12                                 12 
          DEF_Venous_lymphatic_dis            DEF_Colitis_related_dis 
                                12                                 11 
   DEF_COPD_emphy_chron_bronchitis                   DEF_Dorsopathies 
                                11                                 11 
                      DEF_Epilepsy DEF_Neurotic_stress_somatoform_dis 
                                11                                 11 
      DEF_Other_cardiovascular_dis        DEF_Other_genitourinary_dis 
                                11                                 11 
        DEF_Other_neurological_dis          DEF_Peripheral_neuropathy 
                                11                                 11 
               DEF_Solid_neoplasms                      DEF_civil_cat 
                                11                                 11 
                      DEF_Dementia                 DEF_Osteoarthritis 
                                10                                 10 

Distribution of mortality FI (test subset)

Warning: The dot-dot notation (`..density..`) was deprecated in ggplot2 3.4.0.
ℹ Please use `after_stat(density)` instead.

Distribution of hospitalization FI (test subset)

Performance mortality FI (outcome = 1-y mortality ; test subset ; Logistic)

# A tibble: 2 × 7
  term        estimate std.error statistic p.value conf.low conf.high
  <chr>          <dbl>     <dbl>     <dbl>   <dbl>    <dbl>     <dbl>
1 (Intercept)   0.0270    0.0242    -149.        0   0.0258    0.0283
2 FI.m.10       2.50      0.0120      76.7       0   2.45      2.56  
# A tibble: 4 × 7
  term           estimate std.error statistic  p.value   conf.low conf.high
  <chr>             <dbl>     <dbl>     <dbl>    <dbl>      <dbl>     <dbl>
1 (Intercept)  0.00000830   0.133       -87.9 0        0.00000639 0.0000108
2 FI.m.10      2.32         0.0129       65.0 0        2.26       2.38     
3 age          1.11         0.00158      64.7 0        1.10       1.11     
4 factor(Sex)2 0.639        0.0230      -19.5 1.34e-84 0.611      0.668    
                  Predictor Whole Age T1 Age T2 Age T3 Sex 1 Sex 2
FI.m.10.Cstat            FI 0.734  0.787  0.727  0.646 0.739 0.728
age.Cstat               Age 0.728  0.546  0.592  0.615 0.730 0.728
numberdrugs.Cstat   N drugs 0.675  0.675  0.653  0.623 0.662 0.688

Performance hospitalization FI (outcome = 1-y hospitalization ; test subset; Logistic)

# A tibble: 2 × 7
  term        estimate std.error statistic p.value conf.low conf.high
  <chr>          <dbl>     <dbl>     <dbl>   <dbl>    <dbl>     <dbl>
1 (Intercept)    0.208   0.0143     -110.        0    0.202     0.214
2 FI.h.10        2.08    0.00956      76.4       0    2.04      2.12 
# A tibble: 4 × 7
  term         estimate std.error statistic   p.value conf.low conf.high
  <chr>           <dbl>     <dbl>     <dbl>     <dbl>    <dbl>     <dbl>
1 (Intercept)    0.0202  0.0715      -54.6  0           0.0176    0.0232
2 FI.h.10        1.99    0.00964      71.4  0           1.95      2.03  
3 age            1.03    0.000901     33.4  1.56e-244   1.03      1.03  
4 factor(Sex)2   0.949   0.0141       -3.74 1.88e-  4   0.923     0.975 
                  Predictor Whole Age T1 Age T2 Age T3 Sex 1 Sex 2
FI.h.10.Cstat            FI 0.646  0.666  0.647  0.590 0.653 0.637
age.Cstat               Age 0.587  0.526  0.539  0.511 0.594 0.575
numberdrugs.Cstat   N drugs 0.586  0.596  0.585  0.526 0.587 0.582

#ROC plot for 1-y mortality

#ROC plot for 1-y hospitalization

#Predicted 1-y mortality

#Predicted 1-y hospitalization

Warning: Removed 1 rows containing missing values (`geom_point()`).
Warning: Removed 1 row containing missing values (`geom_line()`).

#Prediction in different MM classes

      cluster       AUC
1 Unspecified 0.7453524
2    Neuropsy 0.6343475
3     Complex 0.6261419
4         Eye 0.6786825
5         MSK 0.7240248
6   Metabolic 0.7063995
7          CV 0.7042922

      cluster       AUC
1 Unspecified 0.6019100
2    Neuropsy 0.5521335
3     Complex 0.5728658
4         Eye 0.5862432
5         MSK 0.6090979
6   Metabolic 0.6179196
7          CV 0.6017507