Characteristic	Total	All regsiteries Combined		BRCA Registry			Lynch Registry			Rare Registry
	N = 8491	Newly Identified, N = 4411	Previously Identified, N = 4081	N	Newly Identified, N = 4271	Previously Identified, N = 3981	N	Newly Identified, N = 3541	Previously Identified, N = 3551	N	Newly Identified, N = 1011	Previously Identified, N = 641
Sex				825			709			165
Female	720 (85%)	370 (51%)	350 (49%)		356 (51%)	341 (49%)		303 (50%)	304 (50%)		81 (59%)	56 (41%)
Male	129 (15%)	71 (55%)	58 (45%)		71 (55%)	57 (45%)		51 (50%)	51 (50%)		20 (71%)	8 (29%)
Lynch Syndrome Risk Group	709 (84%)	354 (50%)	355 (50%)	825	340 (50%)	345 (50%)	709	354 (50%)	355 (50%)	165	14 (56%)	11 (44%)
BRCA Risk Group	825 (97%)	427 (52%)	398 (48%)	825	427 (52%)	398 (48%)	709	340 (50%)	345 (50%)	165	87 (62%)	54 (38%)
In Rare Disease_Group	165 (19%)	101 (61%)	64 (39%)	825	87 (62%)	54 (38%)	709	14 (56%)	11 (44%)	165	101 (61%)	64 (39%)
excluded due to having referrals				825			709			165
0	817 (96%)	441 (54%)	376 (46%)		427 (54%)	370 (46%)		354 (52%)	327 (48%)		101 (64%)	56 (36%)
1	32 (3.8%)	0 (0%)	32 (100%)		0 (0%)	28 (100%)		0 (0%)	28 (100%)		0 (0%)	8 (100%)
excluded due to having Genetic Counseling				825			709			165
0	509 (60%)	441 (87%)	68 (13%)		427 (87%)	66 (13%)		354 (85%)	62 (15%)		101 (93%)	8 (7.3%)
1	340 (40%)	0 (0%)	340 (100%)		0 (0%)	332 (100%)		0 (0%)	293 (100%)		0 (0%)	56 (100%)
Has Colorectal Adenocarcinoma Diagnosis	129 (15%)	55 (43%)	74 (57%)	825	54 (43%)	72 (57%)	709	54 (42%)	74 (58%)	165	2 (50%)	2 (50%)
Has Endometrial Adenocarcinoma Diagnosis	147 (17%)	87 (59%)	60 (41%)	825	75 (57%)	56 (43%)	709	87 (60%)	58 (40%)	165	12 (63%)	7 (37%)
Y Has Pheochromocytoma Diagnosis				825			709			165
0	821 (97%)	424 (52%)	397 (48%)		410 (51%)	388 (49%)		354 (50%)	354 (50%)		84 (61%)	53 (39%)
1	28 (3.3%)	17 (61%)	11 (39%)		17 (63%)	10 (37%)		0 (0%)	1 (100%)		17 (61%)	11 (39%)
Y Has Diffuse Gastric Cancer Diagnosis				825			709			165
0	846 (100%)	441 (52%)	405 (48%)		427 (52%)	396 (48%)		354 (50%)	354 (50%)		101 (62%)	61 (38%)
1	3 (0.4%)	0 (0%)	3 (100%)		0 (0%)	2 (100%)		0 (0%)	1 (100%)		0 (0%)	3 (100%)
Y Has Adrenocortical Carcinoma Diagnosis				825			709			165
0	847 (100%)	439 (52%)	408 (48%)		426 (52%)	398 (48%)		353 (50%)	355 (50%)		99 (61%)	64 (39%)
1	2 (0.2%)	2 (100%)	0 (0%)		1 (100%)	0 (0%)		1 (100%)	0 (0%)		2 (100%)	0 (0%)
Y Has Exocrine Pancreatic Cancer Diagnosis				825			709			165
0	812 (96%)	418 (51%)	394 (49%)		404 (51%)	384 (49%)		331 (49%)	342 (51%)		101 (62%)	63 (38%)
1	37 (4.4%)	23 (62%)	14 (38%)		23 (62%)	14 (38%)		23 (64%)	13 (36%)		0 (0%)	1 (100%)
Y Has Metastatic Prostate Cancer Diagnosis				825			709			165
0	846 (100%)	438 (52%)	408 (48%)		424 (52%)	398 (48%)		353 (50%)	355 (50%)		99 (61%)	64 (39%)
1	3 (0.4%)	3 (100%)	0 (0%)		3 (100%)	0 (0%)		1 (100%)	0 (0%)		2 (100%)	0 (0%)
Y Has Ovarian/Fallopian Tube/Peritoneal Diagnosis				825			709			165
0	800 (94%)	419 (52%)	381 (48%)		405 (52%)	371 (48%)		333 (50%)	329 (50%)		100 (61%)	63 (39%)
1	49 (5.8%)	22 (45%)	27 (55%)		22 (45%)	27 (55%)		21 (45%)	26 (55%)		1 (50%)	1 (50%)
Y Has Ocular Melanoma Diagnosis				825			709			165
0	822 (97%)	421 (51%)	401 (49%)		407 (51%)	391 (49%)		354 (50%)	355 (50%)		81 (59%)	57 (41%)
1	27 (3.2%)	20 (74%)	7 (26%)		20 (74%)	7 (26%)					20 (74%)	7 (26%)
Y Has Male Breast Cancer Metric				825			709			165
0	843 (99%)	438 (52%)	405 (48%)		424 (52%)	395 (48%)		353 (50%)	353 (50%)		99 (61%)	63 (39%)
1	6 (0.7%)	3 (50%)	3 (50%)		3 (50%)	3 (50%)		1 (33%)	2 (67%)		2 (67%)	1 (33%)
Y Has Sarcoma Diagnosis				825			709			165
0	782 (92%)	400 (51%)	382 (49%)		398 (51%)	379 (49%)		342 (50%)	347 (50%)		60 (61%)	38 (39%)
1	67 (7.9%)	41 (61%)	26 (39%)		29 (60%)	19 (40%)		12 (60%)	8 (40%)		41 (61%)	26 (39%)
Y Has Renal Cancer Diagnosis				825			709			165
0	836 (98%)	438 (52%)	398 (48%)		424 (52%)	389 (48%)		354 (50%)	354 (50%)		98 (64%)	54 (36%)
1	13 (1.5%)	3 (23%)	10 (77%)		3 (25%)	9 (75%)		0 (0%)	1 (100%)		3 (23%)	10 (77%)
Y Has Medullary Thyroid Cancer Diagnosis				825			709			165
0	842 (99%)	436 (52%)	406 (48%)		422 (52%)	396 (48%)		354 (50%)	355 (50%)		96 (61%)	62 (39%)
1	7 (0.8%)	5 (71%)	2 (29%)		5 (71%)	2 (29%)					5 (71%)	2 (29%)
Y Has Paraganglioma Diagnosis				825			709			165
0	829 (98%)	428 (52%)	401 (48%)		415 (51%)	392 (49%)		353 (50%)	354 (50%)		88 (61%)	57 (39%)
1	20 (2.4%)	13 (65%)	7 (35%)		12 (67%)	6 (33%)		1 (50%)	1 (50%)		13 (65%)	7 (35%)
Y Has Triple Negative Breast Cancer Metric				825			709			165
0	847 (100%)	441 (52%)	406 (48%)		427 (52%)	396 (48%)		354 (50%)	355 (50%)		101 (62%)	62 (38%)
1	2 (0.2%)	0 (0%)	2 (100%)		0 (0%)	2 (100%)					0 (0%)	2 (100%)
Has Breast and Ovarian Gene Mutation Diagnosis (Negative)	12 (1.4%)	0 (0%)	12 (100%)	825	0 (0%)	12 (100%)	709	0 (0%)	11 (100%)	165	0 (0%)	1 (100%)
Has Breast and Ovarian Gene Mutation Diagnosis (Positive)	113 (13%)	0 (0%)	113 (100%)	825	0 (0%)	109 (100%)	709	0 (0%)	107 (100%)	165	0 (0%)	10 (100%)
Patients with 1st degree relatives with early onset of breast cancer				825			709			165
0	646 (76%)	309 (48%)	337 (52%)		309 (48%)	337 (52%)		238 (45%)	290 (55%)		71 (60%)	48 (40%)
1	77 (9.1%)	45 (58%)	32 (42%)		45 (58%)	32 (42%)		44 (59%)	30 (41%)		1 (33%)	2 (67%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients with a male relative (1st & 2nd degree) diagnosed with breast cancer (no age restriction)				825			709			165
0	694 (82%)	334 (48%)	360 (52%)		334 (48%)	360 (52%)		263 (46%)	313 (54%)		71 (60%)	48 (40%)
1	29 (3.4%)	20 (69%)	9 (31%)		20 (69%)	9 (31%)		19 (73%)	7 (27%)		1 (33%)	2 (67%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients with 1st & 2nd degree relatives diagnosed with Ovarian Cancer (no age restriction)				825			709			165
0	550 (65%)	236 (43%)	314 (57%)		236 (43%)	314 (57%)		189 (41%)	267 (59%)		47 (50%)	47 (50%)
1	173 (20%)	118 (68%)	55 (32%)		118 (68%)	55 (32%)		93 (64%)	53 (36%)		25 (89%)	3 (11%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patient has any prostate cancer and 2 or more FamHx of Breast or Prostate Cancer Dx any age 1st & 2nd degree relatives				825			709			165
0	722 (85%)	353 (49%)	369 (51%)		353 (49%)	369 (51%)		281 (47%)	320 (53%)		72 (59%)	50 (41%)
1	1 (0.1%)	1 (100%)	0 (0%)		1 (100%)	0 (0%)		1 (100%)	0 (0%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients with 1st degree relatives diagnosed with Pancreatic Cancer (no age restriction)				825			709			165
0	647 (76%)	305 (47%)	342 (53%)		305 (47%)	342 (53%)		245 (45%)	298 (55%)		60 (57%)	45 (43%)
1	76 (9.0%)	49 (64%)	27 (36%)		49 (64%)	27 (36%)		37 (63%)	22 (37%)		12 (71%)	5 (29%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients dx with Breast cancer between the age of 46-50 and has at least 1 female relative with breast cancer at any age				825			709			165
0	709 (84%)	351 (50%)	358 (50%)		351 (50%)	358 (50%)		279 (47%)	309 (53%)		72 (59%)	50 (41%)
1	14 (1.6%)	3 (21%)	11 (79%)		3 (21%)	11 (79%)		3 (21%)	11 (79%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients diagnosed with any prostate cancer and has family history of breast cancer dx before age 50				825			709			165
0	723 (85%)	354 (49%)	369 (51%)		354 (49%)	369 (51%)		282 (47%)	320 (53%)		72 (59%)	50 (41%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
diagnosed w breast cancer over the age of 50 & has FH of breast cancer (F/M) dx < 50 or 2 or more dx at any age.				825			709			165
0	677 (80%)	334 (49%)	343 (51%)		334 (49%)	343 (51%)		267 (47%)	297 (53%)		67 (59%)	47 (41%)
1	46 (5.4%)	20 (43%)	26 (57%)		20 (43%)	26 (57%)		15 (39%)	23 (61%)		5 (63%)	3 (38%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients dx with Breast cancer at or before the age of 45				825			709			165
0	649 (76%)	321 (49%)	328 (51%)		321 (49%)	328 (51%)		263 (47%)	297 (53%)		58 (64%)	32 (36%)
1	74 (8.7%)	33 (45%)	41 (55%)		33 (45%)	41 (55%)		19 (45%)	23 (55%)		14 (44%)	18 (56%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients dx with Breast cancer at or before the age of 50				825			709			165
0	632 (74%)	317 (50%)	315 (50%)		317 (50%)	315 (50%)		260 (48%)	284 (52%)		57 (64%)	32 (36%)
1	91 (11%)	37 (41%)	54 (59%)		37 (41%)	54 (59%)		22 (38%)	36 (62%)		15 (45%)	18 (55%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Patients dx with Ovarian, Fallopian Tube or peritoneal cancer regardless of age				825			709			165
0	674 (79%)	332 (49%)	342 (51%)		332 (49%)	342 (51%)		261 (47%)	294 (53%)		71 (59%)	49 (41%)
1	49 (5.8%)	22 (45%)	27 (55%)		22 (45%)	27 (55%)		21 (45%)	26 (55%)		1 (50%)	1 (50%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Male patients dx with Breast Cancer regardless of age				825			709			165
0	717 (84%)	351 (49%)	366 (51%)		351 (49%)	366 (51%)		281 (47%)	318 (53%)		70 (59%)	49 (41%)
1	6 (0.7%)	3 (50%)	3 (50%)		3 (50%)	3 (50%)		1 (33%)	2 (67%)		2 (67%)	1 (33%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
PHFM Patients with family history of breast cancer gene mutation				825			709			165
0	698 (82%)	351 (50%)	347 (50%)		351 (50%)	347 (50%)		280 (48%)	298 (52%)		71 (59%)	50 (41%)
1	25 (2.9%)	3 (12%)	22 (88%)		3 (12%)	22 (88%)		2 (8.3%)	22 (92%)		1 (100%)	0 (0%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
PHFMPatients with family history of early onset breast cancer				825			709			165
0	722 (85%)	354 (49%)	368 (51%)		354 (49%)	368 (51%)		282 (47%)	319 (53%)		72 (59%)	50 (41%)
1	1 (0.1%)	0 (0%)	1 (100%)		0 (0%)	1 (100%)		0 (0%)	1 (100%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
PHFM Patients with family history of male breast cancer				825			709			165
0	718 (85%)	353 (49%)	365 (51%)		353 (49%)	365 (51%)		281 (47%)	316 (53%)		72 (59%)	50 (41%)
1	5 (0.6%)	1 (20%)	4 (80%)		1 (20%)	4 (80%)		1 (20%)	4 (80%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
PHFM Patients with family history of ovarian cancer				825			709			165
0	603 (71%)	320 (53%)	283 (47%)		320 (53%)	283 (47%)		255 (51%)	242 (49%)		65 (61%)	42 (39%)
1	120 (14%)	34 (28%)	86 (72%)		34 (28%)	86 (72%)		27 (26%)	78 (74%)		7 (47%)	8 (53%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
PHFM Patients with family history of Pancreatic cancer				825			709			165
0	639 (75%)	343 (54%)	296 (46%)		343 (54%)	296 (46%)		275 (51%)	259 (49%)		68 (64%)	38 (36%)
1	84 (9.9%)	11 (13%)	73 (87%)		11 (13%)	73 (87%)		7 (10%)	61 (90%)		4 (25%)	12 (75%)
NULL	126 (15%)	87 (69%)	39 (31%)		73 (72%)	29 (28%)		72 (67%)	35 (33%)		29 (67%)	14 (33%)
Has CRC Diagnosed <50yo				825			709			165
0	769 (91%)	404 (53%)	365 (47%)		391 (52%)	357 (48%)		317 (50%)	312 (50%)		100 (62%)	62 (38%)
1	80 (9.4%)	37 (46%)	43 (54%)		36 (47%)	41 (53%)		37 (46%)	43 (54%)		1 (33%)	2 (67%)
Has EC Diagnosed <50yo				825			709			165
0	736 (87%)	369 (50%)	367 (50%)		367 (50%)	361 (50%)		282 (47%)	314 (53%)		89 (60%)	59 (40%)
1	113 (13%)	72 (64%)	41 (36%)		60 (62%)	37 (38%)		72 (64%)	41 (36%)		12 (71%)	5 (29%)
Y Colorectal Adenocarcinoma Diagnosis				825			709			165
0	720 (85%)	386 (54%)	334 (46%)		373 (53%)	326 (47%)		300 (52%)	281 (48%)		99 (61%)	62 (39%)
1	129 (15%)	55 (43%)	74 (57%)		54 (43%)	72 (57%)		54 (42%)	74 (58%)		2 (50%)	2 (50%)
Y Endometrial Adenocarcinoma Diagnosis				825			709			165
0	702 (83%)	354 (50%)	348 (50%)		352 (51%)	342 (49%)		267 (47%)	297 (53%)		89 (61%)	57 (39%)
1	147 (17%)	87 (59%)	60 (41%)		75 (57%)	56 (43%)		87 (60%)	58 (40%)		12 (63%)	7 (37%)
Y Has PH FH Lynch Syndrome Diagnosis				825			709			165
0	847 (100%)	440 (52%)	407 (48%)		426 (52%)	397 (48%)		353 (50%)	354 (50%)		101 (61%)	64 (39%)
1	2 (0.2%)	1 (50%)	1 (50%)		1 (50%)	1 (50%)		1 (50%)	1 (50%)
Y Has PH FH Ovarian Cancer Diagnosis				825			709			165
0	729 (86%)	407 (56%)	322 (44%)		393 (56%)	312 (44%)		327 (54%)	277 (46%)		94 (63%)	56 (37%)
1	120 (14%)	34 (28%)	86 (72%)		34 (28%)	86 (72%)		27 (26%)	78 (74%)		7 (47%)	8 (53%)
Y Has PH FH Pancreatic Cancer Diagnosis				825			709			165
0	765 (90%)	430 (56%)	335 (44%)		416 (56%)	325 (44%)		347 (54%)	294 (46%)		97 (65%)	52 (35%)
1	84 (9.9%)	11 (13%)	73 (87%)		11 (13%)	73 (87%)		7 (10%)	61 (90%)		4 (25%)	12 (75%)
Y Lynch Syndrome Diagnosis				825			709			165
0	721 (85%)	441 (61%)	280 (39%)		427 (61%)	275 (39%)		354 (61%)	227 (39%)		101 (63%)	59 (37%)
1	128 (15%)	0 (0%)	128 (100%)		0 (0%)	123 (100%)		0 (0%)	128 (100%)		0 (0%)	5 (100%)
Y Lynch Syndrome Family Cancer History				825			709			165
0	600 (71%)	282 (47%)	318 (53%)		269 (46%)	310 (54%)		195 (42%)	265 (58%)		100 (62%)	62 (38%)
1	249 (29%)	159 (64%)	90 (36%)		158 (64%)	88 (36%)		159 (64%)	90 (36%)		1 (33%)	2 (67%)
Y Number of 1st Degree Relatives with Colon Cancer <50				825			709			165
1	175 (21%)	110 (63%)	65 (37%)		110 (63%)	65 (37%)		110 (63%)	65 (37%)
2	2 (0.2%)	1 (50%)	1 (50%)		1 (50%)	1 (50%)		1 (50%)	1 (50%)
NULL	672 (79%)	330 (49%)	342 (51%)		316 (49%)	332 (51%)		243 (46%)	289 (54%)		101 (61%)	64 (39%)
Y Number of 1st Degree Relatives with Edometrial Cancer <50				825			709			165
1	9 (1.1%)	6 (67%)	3 (33%)		6 (67%)	3 (33%)		6 (67%)	3 (33%)
NULL	840 (99%)	435 (52%)	405 (48%)		421 (52%)	395 (48%)		348 (50%)	352 (50%)		101 (61%)	64 (39%)
FInal_race				825			709			165
AA	63 (7.4%)	41 (65%)	22 (35%)		39 (65%)	21 (35%)		33 (65%)	18 (35%)		10 (67%)	5 (33%)
H	97 (11%)	55 (57%)	42 (43%)		50 (55%)	41 (45%)		48 (55%)	39 (45%)		12 (71%)	5 (29%)
NHW	636 (75%)	321 (50%)	315 (50%)		314 (50%)	308 (50%)		258 (49%)	272 (51%)		70 (58%)	50 (42%)
Other	53 (6.2%)	24 (45%)	29 (55%)		24 (46%)	28 (54%)		15 (37%)	26 (63%)		9 (69%)	4 (31%)
Age_Cat				825			709			165
Early	278 (33%)	149 (54%)	129 (46%)		140 (54%)	121 (46%)		117 (52%)	108 (48%)		41 (58%)	30 (42%)
Middle	360 (42%)	174 (48%)	186 (52%)		170 (48%)	184 (52%)		145 (47%)	164 (53%)		33 (58%)	24 (42%)
Old	211 (25%)	118 (56%)	93 (44%)		117 (56%)	93 (44%)		92 (53%)	83 (47%)		27 (73%)	10 (27%)
visit_Cat				823			706			164
Heavy	670 (79%)	325 (49%)	345 (51%)		319 (49%)	336 (51%)		251 (46%)	296 (54%)		80 (58%)	59 (42%)
Ocasisonal	49 (5.8%)	34 (69%)	15 (31%)		33 (69%)	15 (31%)		30 (70%)	13 (30%)		5 (71%)	2 (29%)
Regular	127 (15%)	80 (63%)	47 (37%)		73 (61%)	47 (39%)		71 (61%)	45 (39%)		16 (89%)	2 (11%)
Unknown	3	2	1		2	0		2	1		0	1
gen_status
Newly Identified	441 (52%)
Previously Identified	408 (48%)
1 n (%)