- SARS-CoV-2 and Host PPI
- Drug network with action
- 提取Omics分析得到的AKI关联基因与SARS2相互作用的部分
- Get many other databases’ cross-reference
- Genome distribution
- Functional enrichment analysis
- Drug search demo
- 提取Omics分析得到的AKI关联基因与SARS2 S protein 相互作用的部分(Only S protein)
- Get many other databases’ cross-reference of S
- Functional enrichment analysis of S interacted proteins
SARS-CoV-2 and Host PPI
Drug network with action
提取Omics分析得到的AKI关联基因与SARS2相互作用的部分
Get many other databases’ cross-reference
Genome distribution
Functional enrichment analysis
GOBP enrich
GOBP plot
KEGG enrich
Reactome enrich
Targeted Drug ChEBI enrich
HPO enrich
Curated.MSigDB enrich
Drug Perturbations down
Drug search demo
富集的Reactome通路第一个为Eukaryotic Translation Initiation（eIF）
该通路是真核生物翻译的起始过程中的一个关键步骤。研究表明，COVID-19病毒的复制和繁殖需要利用宿主细胞的翻译机器来合成病毒蛋白质，其中eIF是必不可少的因子之一。具体来说，COVID-19病毒基因组的5’端包含一个称为“冠状病毒帽子结构”的非编码区域（NCR），该结构通过eIF4E和eIF4G结合并招募eIF4A，从而促进翻译机器的组装和病毒基因的翻译。研究表明，COVID-19病毒的NCR区域在结构和功能上与其他冠状病毒不同，这可能解释了为什么COVID-19病毒比其他冠状病毒更具传染性和致病性。
因此，eIF可能成为抗COVID-19药物研发的重要靶点。研究人员已经开始研究利用eIF4A抑制剂来抑制病毒的繁殖，或者使用抗体来阻断eIF4E和eIF4G与NCR的结合，从而阻止病毒蛋白质的合成。
把富集到该生物通路的基因输出到Drugxplore 的Drug-target Network模块, 结果如下：
- Artenimol 青蒿素 is a derivative of the antimalarial agent artemisinin. A study has shown that artemisinin and its derivatives portray more potent binding to Lys353 and Lys31-binding hotspots of SARS-CoV-2 spike protein than hydroxychloroquine1. This suggests the potential repurposing of artenimol for COVID-19 treatment1
- Anisomycin 茴香霉素 is a potential anti-SARS-CoV-2 virus drug that targets key enzymes using virtual computational approaches1. It is being considered for repurposing as a treatment for COVID-191.
- Quercetin 槲皮素 is a plant pigment that contains antioxidant properties and may reduce inflammation, allergy symptoms, and blood pressure. Some recent studies have found promising results for its use in treating COVID-19, but rigorous clinical trial data is lacking1. Quercetin is reported to be effective on treatment and prophylaxis of other SARS-like coronavirus infections, as a strong antioxidant and scavenger flavonoid without any adverse events2.
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提取Omics分析得到的AKI关联基因与SARS2 S protein 相互作用的部分(Only S protein)
Get many other databases’ cross-reference of S
Functional enrichment analysis of S interacted proteins
GOBP enrich
GOBP plot
