Dataset

#Load Ozone Dataset
load("Ozone Data with Region.RData")
combinedAir.final<-df4
combinedAir.final<-arrange(combinedAir.final,MonitorID,Year)

combinedAir.final$USDM.categorical<-factor(combinedAir.final$USDM.categorical,levels=c("NoDrought","ModerateDrought","SevereDrought"))

Overall

md2_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =combinedAir.final,
                index = c("MonitorID","Year","month"),
                model = "random")

md2_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =combinedAir.final,
                index = c("MonitorID","Year","month"),
                model = "between")


stargazer(md2_random,md2_fix,type = "text", title = "All Regions", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## All Regions
## =============================================================================
##                                         Dependent Variable: Ozone Max        
##                                 ---------------------------------------------
##                                 Random Effect Model    Fixed Effect Model    
## -----------------------------------------------------------------------------
## USDM.categoricalModerateDrought      0.489***               3.039***         
##                                       (0.012)                (0.756)         
##                                                                              
## USDM.categoricalSevereDrought        0.281***               4.763***         
##                                       (0.018)                (1.041)         
##                                                                              
## elevation                            0.004***               0.007***         
##                                      (0.0002)               (0.0003)         
##                                                                              
## Longitude                            0.147***               0.091***         
##                                       (0.006)                (0.010)         
##                                                                              
## Latitude                             0.215***               0.400***         
##                                       (0.020)                (0.031)         
##                                                                              
## tdmean                               -0.848***               -0.025          
##                                       (0.001)                (0.047)         
##                                                                              
## tmean                                1.359***               0.991***         
##                                       (0.001)                (0.040)         
##                                                                              
## ppt                                  -0.134***               -0.142          
##                                       (0.001)                (0.165)         
##                                                                              
## Constant                             32.058***              16.369***        
##                                       (0.999)                (2.097)         
##                                                                              
## -----------------------------------------------------------------------------
## Model Name                      Random Effect Model    Fixed Effect Model    
## Observations                         6,589,427                1,959          
## R2                                     0.223                  0.486          
## Adjusted R2                            0.223                  0.484          
## F Statistic                      1,857,483.000***   230.701*** (df = 8; 1950)
## =============================================================================
## Note:                                             *p<0.1; **p<0.05; ***p<0.01

Northeast

ne<- combinedAir.final%>%
  filter(noaa_region=="northeast")

ne_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =ne,
                index = c("MonitorID","Year","month"),
                model = "random")

ne_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =ne,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(ne_random,ne_fix,type = "text", title = "Northeast", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Northeast
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      -0.359***              -1.113         
##                                       (0.043)               (3.360)        
##                                                                            
## USDM.categoricalSevereDrought        -1.274***               0.637         
##                                       (0.141)               (8.871)        
##                                                                            
## elevation                            0.013***              0.012***        
##                                       (0.001)               (0.002)        
##                                                                            
## Longitude                            0.298***              0.321***        
##                                       (0.080)               (0.117)        
##                                                                            
## Latitude                             -0.703***             -0.793***       
##                                       (0.137)               (0.209)        
##                                                                            
## tdmean                               -1.343***             2.176***        
##                                       (0.004)               (0.283)        
##                                                                            
## tmean                                1.932***              -0.958***       
##                                       (0.005)               (0.289)        
##                                                                            
## ppt                                  -0.059***             -1.657***       
##                                       (0.002)               (0.495)        
##                                                                            
## Constant                             74.381***             96.922***       
##                                      (10.875)              (17.402)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          960,225                 283          
## R2                                     0.245                 0.636         
## Adjusted R2                            0.245                 0.626         
## F Statistic                       303,857.100***    59.912*** (df = 8; 274)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

Northern Rockies

nr<- combinedAir.final%>%
  filter(noaa_region=="northern_rockies")

nr_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =nr,
                index = c("MonitorID","Year","month"),
                model = "random")

nr_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =nr,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(nr_random,nr_fix,type = "text", title = "Northern Rockies", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Northern Rockies
## ==========================================================================
##                                       Dependent Variable: Ozone Max       
##                                 ------------------------------------------
##                                 Random Effect Model   Fixed Effect Model  
## --------------------------------------------------------------------------
## USDM.categoricalModerateDrought      0.123***               1.972         
##                                       (0.044)              (1.199)        
##                                                                           
## USDM.categoricalSevereDrought        -0.287***             4.580**        
##                                       (0.069)              (2.293)        
##                                                                           
## elevation                            0.006***              0.009***       
##                                       (0.001)              (0.001)        
##                                                                           
## Longitude                            0.213***              0.384***       
##                                       (0.067)              (0.107)        
##                                                                           
## Latitude                              -0.043                0.301         
##                                       (0.110)              (0.185)        
##                                                                           
## tdmean                               -0.478***              0.016         
##                                       (0.005)              (0.293)        
##                                                                           
## tmean                                0.711***              0.470**        
##                                       (0.004)              (0.208)        
##                                                                           
## ppt                                  -0.046***              -0.317        
##                                       (0.004)              (0.742)        
##                                                                           
## Constant                             52.635***            53.151***       
##                                       (5.044)              (8.711)        
##                                                                           
## --------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model  
## Observations                          226,906                 94          
## R2                                     0.230                0.795         
## Adjusted R2                            0.230                0.775         
## F Statistic                        55,811.320***    41.085*** (df = 8; 85)
## ==========================================================================
## Note:                                          *p<0.1; **p<0.05; ***p<0.01

Northwest

nw<- combinedAir.final%>%
  filter(noaa_region=="northwest")

nw_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =nw,
                index = c("MonitorID","Year","month"),
                model = "random")

nw_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =nw,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(nw_random,nw_fix,type = "text", title = "Northwest", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Northwest
## ==========================================================================
##                                       Dependent Variable: Ozone Max       
##                                 ------------------------------------------
##                                 Random Effect Model   Fixed Effect Model  
## --------------------------------------------------------------------------
## USDM.categoricalModerateDrought      -0.396***              -0.023        
##                                       (0.073)              (2.136)        
##                                                                           
## USDM.categoricalSevereDrought        -2.017***              6.229         
##                                       (0.167)              (5.737)        
##                                                                           
## elevation                            0.003***              0.007***       
##                                       (0.001)              (0.002)        
##                                                                           
## Longitude                             0.298*               0.568**        
##                                       (0.154)              (0.275)        
##                                                                           
## Latitude                              -0.321                -0.061        
##                                       (0.218)              (0.324)        
##                                                                           
## tdmean                               -1.320***              -0.578        
##                                       (0.011)              (0.424)        
##                                                                           
## tmean                                1.320***              1.600***       
##                                       (0.008)              (0.259)        
##                                                                           
## ppt                                  0.152***              1.072**        
##                                       (0.005)              (0.411)        
##                                                                           
## Constant                             76.315***             83.933**       
##                                      (18.593)              (38.752)       
##                                                                           
## --------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model  
## Observations                          105,338                 58          
## R2                                     0.207                0.834         
## Adjusted R2                            0.207                0.806         
## F Statistic                        24,962.300***    30.669*** (df = 8; 49)
## ==========================================================================
## Note:                                          *p<0.1; **p<0.05; ***p<0.01

Ohio Valley

ohv<- combinedAir.final%>%
  filter(noaa_region=="ohio_valley")

ohv_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =ohv,
                index = c("MonitorID","Year","month"),
                model = "random")

ohv_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =ohv,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(ohv_random,ohv_fix,type = "text", title = "Ohio Valley", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Ohio Valley
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      0.322***                2.873         
##                                       (0.038)               (1.963)        
##                                                                            
## USDM.categoricalSevereDrought        -0.640***               6.632         
##                                       (0.090)               (8.185)        
##                                                                            
## elevation                            0.008***              0.007***        
##                                       (0.001)               (0.002)        
##                                                                            
## Longitude                            0.225***              0.260***        
##                                       (0.038)               (0.056)        
##                                                                            
## Latitude                             -0.559***             -0.310***       
##                                       (0.064)               (0.112)        
##                                                                            
## tdmean                               -1.589***             1.816***        
##                                       (0.005)               (0.391)        
##                                                                            
## tmean                                2.199***               -0.411         
##                                       (0.005)               (0.361)        
##                                                                            
## ppt                                  -0.143***             -1.788***       
##                                       (0.001)               (0.503)        
##                                                                            
## Constant                             64.365***             69.282***       
##                                       (4.545)               (8.129)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                         1,006,480                342          
## R2                                     0.280                 0.632         
## Adjusted R2                            0.280                 0.623         
## F Statistic                       374,606.500***    71.415*** (df = 8; 333)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

South

sth<- combinedAir.final%>%
  filter(noaa_region=="south")

sth_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =sth,
                index = c("MonitorID","Year","month"),
                model = "random")

sth_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =sth,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(sth_random,sth_fix,type = "text", title = "South", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## South
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought        0.001                 0.224         
##                                       (0.031)               (1.852)        
##                                                                            
## USDM.categoricalSevereDrought        -0.378***               2.677         
##                                       (0.047)               (2.701)        
##                                                                            
## elevation                            -0.005***             0.007***        
##                                       (0.001)               (0.003)        
##                                                                            
## Longitude                            0.498***               0.259*         
##                                       (0.070)               (0.142)        
##                                                                            
## Latitude                             0.954***              1.153***        
##                                       (0.061)               (0.123)        
##                                                                            
## tdmean                               -1.345***               0.023         
##                                       (0.004)               (0.245)        
##                                                                            
## tmean                                1.774***              1.008***        
##                                       (0.004)               (0.242)        
##                                                                            
## ppt                                  -0.079***               0.250         
##                                       (0.001)               (0.547)        
##                                                                            
## Constant                             41.099***               5.479         
##                                       (7.322)              (17.967)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          951,486                 236          
## R2                                     0.220                 0.440         
## Adjusted R2                            0.220                 0.420         
## F Statistic                       257,802.400***    22.278*** (df = 8; 227)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

Southeast

se<- combinedAir.final%>%
  filter(noaa_region=="southeast")

se_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =se,
                index = c("MonitorID","Year","month"),
                model = "random")

se_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =se,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(se_random,se_fix,type = "text", title = "Southeast", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Southeast
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      2.394***                1.693         
##                                       (0.031)               (1.940)        
##                                                                            
## USDM.categoricalSevereDrought        3.188***              19.841***       
##                                       (0.046)               (2.637)        
##                                                                            
## elevation                            0.008***              0.006***        
##                                       (0.001)               (0.001)        
##                                                                            
## Longitude                             -0.010                -0.031         
##                                       (0.049)               (0.065)        
##                                                                            
## Latitude                             0.599***              1.054***        
##                                       (0.044)               (0.075)        
##                                                                            
## tdmean                               -2.057***               0.368         
##                                       (0.005)               (0.334)        
##                                                                            
## tmean                                2.347***                0.456         
##                                       (0.005)               (0.333)        
##                                                                            
## ppt                                  -0.079***             -0.848**        
##                                       (0.001)               (0.394)        
##                                                                            
## Constant                               2.786                -9.244         
##                                       (4.772)               (6.480)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          982,391                 273          
## R2                                     0.212                 0.690         
## Adjusted R2                            0.212                 0.681         
## F Statistic                       252,128.100***    73.575*** (df = 8; 264)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

Southwest

sw<- combinedAir.final%>%
  filter(noaa_region=="southwest")

sw_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =sw,
                index = c("MonitorID","Year","month"),
                model = "random")

sw_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =sw,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(sw_random,sw_fix,type = "text", title = "Southwest", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Southwest
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      0.184***                1.490         
##                                       (0.028)               (1.464)        
##                                                                            
## USDM.categoricalSevereDrought        1.158***               -1.674         
##                                       (0.035)               (1.592)        
##                                                                            
## elevation                            0.006***              0.006***        
##                                      (0.0003)               (0.001)        
##                                                                            
## Longitude                            -0.335***             -0.287**        
##                                       (0.075)               (0.123)        
##                                                                            
## Latitude                             0.517***              0.473***        
##                                       (0.070)               (0.117)        
##                                                                            
## tdmean                               -0.353***             -0.574***       
##                                       (0.002)               (0.184)        
##                                                                            
## tmean                                0.953***              1.165***        
##                                       (0.002)               (0.126)        
##                                                                            
## ppt                                  0.018***               1.548**        
##                                       (0.004)               (0.663)        
##                                                                            
## Constant                            -31.579***            -29.743***       
##                                       (8.642)              (11.375)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          683,530                 223          
## R2                                     0.343                 0.593         
## Adjusted R2                            0.343                 0.578         
## F Statistic                       342,623.700***    39.007*** (df = 8; 214)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

Upper Midwest

um<- combinedAir.final%>%
  filter(noaa_region=="upper_midwest")

um_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =um,
                index = c("MonitorID","Year","month"),
                model = "random")

um_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =um,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(um_random,um_fix,type = "text", title = "Upper Midwest", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## Upper Midwest
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      -0.377***              -7.331         
##                                       (0.056)               (4.706)        
##                                                                            
## USDM.categoricalSevereDrought        -1.766***               6.445         
##                                       (0.187)              (19.508)        
##                                                                            
## elevation                              0.002                0.009*         
##                                       (0.003)               (0.004)        
##                                                                            
## Longitude                            0.278***              0.292***        
##                                       (0.065)               (0.103)        
##                                                                            
## Latitude                             -0.335**                0.284         
##                                       (0.148)               (0.207)        
##                                                                            
## tdmean                               -1.415***             2.199***        
##                                       (0.007)               (0.509)        
##                                                                            
## tmean                                1.741***               -0.880*        
##                                       (0.007)               (0.448)        
##                                                                            
## ppt                                  -0.080***              -1.293         
##                                       (0.002)               (0.912)        
##                                                                            
## Constant                             67.945***             50.717***       
##                                       (8.117)              (11.589)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          382,355                 128          
## R2                                     0.182                 0.592         
## Adjusted R2                            0.182                 0.565         
## F Statistic                        81,562.780***    21.591*** (df = 8; 119)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01

West

wst<- combinedAir.final%>%
  filter(noaa_region=="upper_midwest")

wst_random<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =wst,
                index = c("MonitorID","Year","month"),
                model = "random")

wst_fix<-plm(Max.Ozone~USDM.categorical +elevation+ Longitude + Latitude+tdmean+tmean+ppt,
                data =wst,
                index = c("MonitorID","Year","month"),
                model = "between")

stargazer(wst_random,wst_fix,type = "text", title = "West", align = TRUE,
  add.lines = list(c("Model Name", "Random Effect Model", "Fixed Effect Model")),
  column.labels = c("Random Effect Model", "Fixed Effect Model"),
  dep.var.caption = "Dependent Variable: Ozone Max",
  dep.var.labels.include = FALSE,
  omit.table.layout = "#")
## 
## West
## ===========================================================================
##                                        Dependent Variable: Ozone Max       
##                                 -------------------------------------------
##                                 Random Effect Model   Fixed Effect Model   
## ---------------------------------------------------------------------------
## USDM.categoricalModerateDrought      -0.377***              -7.331         
##                                       (0.056)               (4.706)        
##                                                                            
## USDM.categoricalSevereDrought        -1.766***               6.445         
##                                       (0.187)              (19.508)        
##                                                                            
## elevation                              0.002                0.009*         
##                                       (0.003)               (0.004)        
##                                                                            
## Longitude                            0.278***              0.292***        
##                                       (0.065)               (0.103)        
##                                                                            
## Latitude                             -0.335**                0.284         
##                                       (0.148)               (0.207)        
##                                                                            
## tdmean                               -1.415***             2.199***        
##                                       (0.007)               (0.509)        
##                                                                            
## tmean                                1.741***               -0.880*        
##                                       (0.007)               (0.448)        
##                                                                            
## ppt                                  -0.080***              -1.293         
##                                       (0.002)               (0.912)        
##                                                                            
## Constant                             67.945***             50.717***       
##                                       (8.117)              (11.589)        
##                                                                            
## ---------------------------------------------------------------------------
## Model Name                      Random Effect Model   Fixed Effect Model   
## Observations                          382,355                 128          
## R2                                     0.182                 0.592         
## Adjusted R2                            0.182                 0.565         
## F Statistic                        81,562.780***    21.591*** (df = 8; 119)
## ===========================================================================
## Note:                                           *p<0.1; **p<0.05; ***p<0.01