Final Project Idea: Effects of COVID-19 on Vaccine Preventable Diseases

Project Aims

Aim 1: Characterize temporal, geospatial distribution of VPD cases, immunizations compared to COVID-19

Research question: Has the COVID-19 pandemic and associated vaccination campaigns cannibalized resources and progress on previous set targets for Vaccine preventable disease?

Hypothesis: Advent of COVID-19 pandemic cases led to increased surveillance of COVID-19 and eventually increased immunization while surveilled cases and immunizations for VPDs decreased.

Aim 2: Highlight linkages between COVID-19 pandemic, economic shock, new COVID-19 vaccine, prices to VPD vaccines

Research question: Has the economic shock of COVID-19 and R&D focus on the COVID-19 vaccine distorted prices to VPD vaccines

Hypothesis: While GDP growth and GNI of countries slowed or shrank in the Pandemic, prices to VPD vaccines increased and became relatively more expensive.

Aim 3: Determine the cost vs. benefit of added investment into VPD vaccines and immunization coverage

Research question: Is the benefit of added investment into VPD vaccines and immunization coverage greater than/needed against the cost of VPDs

Hypothesis: The cost of VPDs far exceeds the cost and benefit of investing in VPD vaccines and coverage programs

Data tidying

Step 1: Libraries

Load libraries for R. Note: additional libraries may be added later for specific visualization techniques, data exploration, and summary statistics.

#| echo: false
#| warning: false

#load libraries for use

library(tidyverse)
library(lubridate)
library(purrr)
library(janitor)
library(here)
library(readxl)
library(ggridges)
library(stringr)
library(naniar)

library(rnaturalearth)
library(countrycode)
library(wbstats)

library("data.table")

setwd("C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/")

Step 2: World Bank Data

First need function from earlier in class to help locate countries and use ISO3 codes for WB data and table joins. Created below:

#| echo: false
#| warning: false

#searching gdp data

wb_search("gdp") |> 
  view()

wb_search("gni") |> 
  view()

#build functions to help generate locations

country_name_regex_to_iso3c <- function(country_name) {
  country_name |>
    countrycode(origin = "country.name", 
                                     destination = "iso3c",
                                     origin_regex = TRUE)
}

iso3c_to_country_name <- function(country_string) {
  country_string %>%
    countrycode::countrycode(origin = "iso3c", destination = "country.name")
} 

character_num_to_numeric <- function(character_num) {
  character_num %>%
  # take out the commas
  stringr::str_remove_all(pattern = ",") %>%
  # take out any blank spaces before or after the number
  stringr::str_trim() %>%
  # coerce to numeric
  as.numeric()
}

iso3c_to_x <- purrr::partial(countrycode, origin = "iso3c")

Next will be loading in data needed from API (GDP, GNI, Population, per capita calcs?). Getting World Bank API data for country-level analysis below. (Data Source: WB Stats API)

#| echo: false
#| warning: false

##Get our WB data via the API

wb_population <- wb_data("SP.POP.TOTL") # our population data
wb_gdp_ppp <- wb_data("NY.GDP.MKTP.PP.CD") # ppp real GDP data
wb_gdp_nominal <- wb_data("NY.GDP.MKTP.CD") # real GDP data
wb_gni_ppp <- wb_data("NY.GNP.MKTP.PP.CD") # ppp real GNI data
wb_gni_nominal <- wb_data ("NY.GNP.MKTP.CD")# nominal real GNI data
wb_regions <- wb_countries() #regions data
wb_growth <- wb_data("NY.GDP.MKTP.KD.ZG") #GDP growth rates
wb_health_exp <- wb_data("SH.XPD.CHEX.GD.ZS") #Health expenditure as % GDP

Cleaning up names of columns for later table joins:

#| echo: false
#| warning: false

##Clean up WB data

wb_gni_nominal <- wb_gni_nominal |>
  rename(year = date, country_name = country,  gni = NY.GNP.MKTP.CD) |> 
  select(-iso2c,-unit,-obs_status,-footnote,-last_updated)

wb_gni_ppp <- wb_gni_ppp |>
  rename(year = date, country_name = country, gni_ppp = NY.GNP.MKTP.PP.CD) |> 
  select(-iso2c,-unit,-obs_status,-footnote,-last_updated)

wb_gdp_nominal <- wb_gdp_nominal |>
  rename(year = date, country_name = country, gdp = NY.GDP.MKTP.CD) |> 
  select(-iso2c,-unit,-obs_status,-footnote,-last_updated)

wb_gdp_ppp <- wb_gdp_ppp |>
  rename(year = date, country_name = country, gdp_ppp = NY.GDP.MKTP.PP.CD) |> 
  select(-iso2c,-unit,-obs_status,-footnote,-last_updated)

wb_population <- wb_population |>
  rename(year = date, country_name = country, pop_total = SP.POP.TOTL) |> 
  select(-iso2c,-unit,-obs_status,-footnote,-last_updated)

wb_regions <- wb_regions |>
  select(iso3c, country, region, income_level) |> 
  filter(region != "Aggregates")

wb_growth <- wb_growth |> 
  rename(gdp_growth = NY.GDP.MKTP.KD.ZG, year = date) |> 
  select(iso3c, country, year, gdp_growth)

wb_health_exp <- wb_health_exp |> 
  mutate(gdp_health = SH.XPD.CHEX.GD.ZS, year = date) |> 
  select(iso3c, country, year, gdp_health)

Now let’s join all the WB data together into one table using a series of Left Joins and filters to condense our time frame to >= 1990 :

#Left joins beginning with nominal GDP as reference sheet

#Join 1: GDP
          
wb_gdp <- wb_gdp_nominal |> 
          left_join(wb_gdp_ppp, by = c("iso3c", "country_name", "year"))

wb_gdp
## # A tibble: 13,454 × 5
##    iso3c country_name  year   gdp gdp_ppp
##    <chr> <chr>        <dbl> <dbl>   <dbl>
##  1 ABW   Aruba         1960    NA      NA
##  2 ABW   Aruba         1961    NA      NA
##  3 ABW   Aruba         1962    NA      NA
##  4 ABW   Aruba         1963    NA      NA
##  5 ABW   Aruba         1964    NA      NA
##  6 ABW   Aruba         1965    NA      NA
##  7 ABW   Aruba         1966    NA      NA
##  8 ABW   Aruba         1967    NA      NA
##  9 ABW   Aruba         1968    NA      NA
## 10 ABW   Aruba         1969    NA      NA
## # ℹ 13,444 more rows
#Join 2: GNI

wb_gni <- wb_gni_nominal |> 
          left_join(wb_gni_ppp, by = c("iso3c", "country_name", "year")) 

wb_gni
## # A tibble: 13,454 × 5
##    iso3c country_name  year   gni gni_ppp
##    <chr> <chr>        <dbl> <dbl>   <dbl>
##  1 ABW   Aruba         1960    NA      NA
##  2 ABW   Aruba         1961    NA      NA
##  3 ABW   Aruba         1962    NA      NA
##  4 ABW   Aruba         1963    NA      NA
##  5 ABW   Aruba         1964    NA      NA
##  6 ABW   Aruba         1965    NA      NA
##  7 ABW   Aruba         1966    NA      NA
##  8 ABW   Aruba         1967    NA      NA
##  9 ABW   Aruba         1968    NA      NA
## 10 ABW   Aruba         1969    NA      NA
## # ℹ 13,444 more rows
#Join 3: Combined GDP GNI

wb_econ_data <- wb_gdp |> 
          left_join(wb_gni, by = c("iso3c", "country_name", "year"))

wb_econ_data
## # A tibble: 13,454 × 7
##    iso3c country_name  year   gdp gdp_ppp   gni gni_ppp
##    <chr> <chr>        <dbl> <dbl>   <dbl> <dbl>   <dbl>
##  1 ABW   Aruba         1960    NA      NA    NA      NA
##  2 ABW   Aruba         1961    NA      NA    NA      NA
##  3 ABW   Aruba         1962    NA      NA    NA      NA
##  4 ABW   Aruba         1963    NA      NA    NA      NA
##  5 ABW   Aruba         1964    NA      NA    NA      NA
##  6 ABW   Aruba         1965    NA      NA    NA      NA
##  7 ABW   Aruba         1966    NA      NA    NA      NA
##  8 ABW   Aruba         1967    NA      NA    NA      NA
##  9 ABW   Aruba         1968    NA      NA    NA      NA
## 10 ABW   Aruba         1969    NA      NA    NA      NA
## # ℹ 13,444 more rows
#Filter data set to same time range before join (>= 1990)

wb_econ_data <- wb_econ_data |> 
                rename(country = country_name) |> 
                filter(year >= "1990")
      

wb_econ_data
## # A tibble: 6,944 × 7
##    iso3c country  year         gdp     gdp_ppp         gni     gni_ppp
##    <chr> <chr>   <dbl>       <dbl>       <dbl>       <dbl>       <dbl>
##  1 ABW   Aruba    1990  764804469. 1363755809.  757039106. 1348704439.
##  2 ABW   Aruba    1991  872067039. 1522141299.  864301676. 1507408172.
##  3 ABW   Aruba    1992  958659218. 1648407758.  948994413. 1630343441.
##  4 ABW   Aruba    1993 1083240223. 1810796527. 1065363128. 1778312497.
##  5 ABW   Aruba    1994 1245810056. 2001192964. 1225810056. 1966271278.
##  6 ABW   Aruba    1995 1320670391. 2095198113. 1305474860. 2068993690.
##  7 ABW   Aruba    1996 1379888268. 2158860032. 1362067039. 2128552799.
##  8 ABW   Aruba    1997 1531843575. 2350843673. 1508659218. 2312168482.
##  9 ABW   Aruba    1998 1665363128. 2424658707. 1659776536. 2415817395.
## 10 ABW   Aruba    1999 1722905028. 2489269109. 1680223464. 2422237613.
## # ℹ 6,934 more rows
#Join 4: Add Regions

wb_reg <- wb_econ_data |> 
                left_join(wb_regions, by = c("iso3c", "country"))

#Join 5: Add Growth Rates (do later once API catches up to IMF)

#Join 6: Add Health Expenditure

wb_data <- wb_reg |> 
                left_join(wb_health_exp, by = c("iso3c", "country", "year"))

wb_data
## # A tibble: 6,944 × 10
##    iso3c country  year         gdp    gdp_ppp    gni gni_ppp region income_level
##    <chr> <chr>   <dbl>       <dbl>      <dbl>  <dbl>   <dbl> <chr>  <chr>       
##  1 ABW   Aruba    1990  764804469.     1.36e9 7.57e8  1.35e9 Latin… High income 
##  2 ABW   Aruba    1991  872067039.     1.52e9 8.64e8  1.51e9 Latin… High income 
##  3 ABW   Aruba    1992  958659218.     1.65e9 9.49e8  1.63e9 Latin… High income 
##  4 ABW   Aruba    1993 1083240223.     1.81e9 1.07e9  1.78e9 Latin… High income 
##  5 ABW   Aruba    1994 1245810056.     2.00e9 1.23e9  1.97e9 Latin… High income 
##  6 ABW   Aruba    1995 1320670391.     2.10e9 1.31e9  2.07e9 Latin… High income 
##  7 ABW   Aruba    1996 1379888268.     2.16e9 1.36e9  2.13e9 Latin… High income 
##  8 ABW   Aruba    1997 1531843575.     2.35e9 1.51e9  2.31e9 Latin… High income 
##  9 ABW   Aruba    1998 1665363128.     2.42e9 1.66e9  2.42e9 Latin… High income 
## 10 ABW   Aruba    1999 1722905028.     2.49e9 1.68e9  2.42e9 Latin… High income 
## # ℹ 6,934 more rows
## # ℹ 1 more variable: gdp_health <dbl>

Look for any unique or missing values, it appears there are 712 missing observations for GDP/GNI measurements for countries. These can be tolerated for analysis as we are looking at global trends and more interested in disease trends.

#Take a look at data so far using glimpse() command

glimpse(wb_data)
## Rows: 6,944
## Columns: 10
## $ iso3c        <chr> "ABW", "ABW", "ABW", "ABW", "ABW", "ABW", "ABW", "ABW", "…
## $ country      <chr> "Aruba", "Aruba", "Aruba", "Aruba", "Aruba", "Aruba", "Ar…
## $ year         <dbl> 1990, 1991, 1992, 1993, 1994, 1995, 1996, 1997, 1998, 199…
## $ gdp          <dbl> 764804469, 872067039, 958659218, 1083240223, 1245810056, …
## $ gdp_ppp      <dbl> 1363755809, 1522141299, 1648407758, 1810796527, 200119296…
## $ gni          <dbl> 757039106, 864301676, 948994413, 1065363128, 1225810056, …
## $ gni_ppp      <dbl> 1348704439, 1507408172, 1630343441, 1778312497, 196627127…
## $ region       <chr> "Latin America & Caribbean", "Latin America & Caribbean",…
## $ income_level <chr> "High income", "High income", "High income", "High income…
## $ gdp_health   <dbl> NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, NA, N…
#Show unique countries & values


#Show unique missing values

unique_missing_obs <- wb_data %>%
  filter(!complete.cases(.)) %>%
  distinct()

#What's missing from keys

wb_data |> 
  filter(is.na(iso3c) | is.na(country) | is.na(year) | is.na(region)) |> 
  select(iso3c, country, year, region) |> 
  unique()
## # A tibble: 0 × 4
## # ℹ 4 variables: iso3c <chr>, country <chr>, year <dbl>, region <chr>
#What's missing from indicators

wb_data |> 
  filter(is.na(gdp) | is.na(gdp_ppp) | is.na(gni) | is.na(gni_ppp)) |> 
  select(country, gdp, gdp_ppp, gni, gni_ppp) |> 
  unique()
## # A tibble: 712 × 5
##    country              gdp      gdp_ppp   gni gni_ppp
##    <chr>              <dbl>        <dbl> <dbl>   <dbl>
##  1 Afghanistan          NA           NA     NA      NA
##  2 Afghanistan  3854235264. 19805683002.    NA      NA
##  3 Afghanistan  4539500884. 21980384806.    NA      NA
##  4 Afghanistan  5220823685. 22889600504.    NA      NA
##  5 Afghanistan  6226199249. 26258419344.    NA      NA
##  6 Afghanistan  6971379033. 28518821098.    NA      NA
##  7 Afghanistan  9715761650. 33339216567.    NA      NA
##  8 Afghanistan 10249767311. 35312296534.    NA      NA
##  9 Andorra      1029048482.          NA     NA      NA
## 10 Andorra      1106928583.          NA     NA      NA
## # ℹ 702 more rows

Step 3: VPDs

Load in VPD case data (Source: WHO VPD Immunization Data). We will need to clean up the Tetanus observations as there are some for both total tetanus and neonatal tetanus. While this stratification is important it is not relevant to this particular analysis. We can drop the neonatal tetanus observations since they are assumed to be included in the “total tetanus” observations. Then using “mutate” we can rename “Total tetatnus” descriptions to simply “Tetanus”. Finally using the naniar package in R we can summarize our missingness to see it is limited solely to case data for a number of countries. Given the time range and purpose of this assignment we can tolerate these missing values for now, although the fact that they include the entire date range and all countries in the data set some more specific questions and filtering are needed for in-depth analysis and modelling.

#| warning: false

#Load in Incidence Rate

vpd_ir <- read_excel("C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/00_data_raw/VPDs/vpd_incidence_rate_2021.xlsx") |> 
  rename(group = GROUP, iso3c =CODE, country = NAME, year = YEAR, disease = DISEASE, disease_desc = DISEASE_DESCRIPTION, units= DENOMINATOR, ir = INCIDENCE_RATE) |> 
  filter(group == "COUNTRIES")

vpd_ir
## # A tibble: 76,842 × 8
##    group     iso3c country  year disease    disease_desc             units    ir
##    <chr>     <chr> <chr>   <dbl> <chr>      <chr>                    <chr> <dbl>
##  1 COUNTRIES ABW   Aruba    2021 CRS        Congenital rubella synd… per …     0
##  2 COUNTRIES ABW   Aruba    2021 DIPHTHERIA Diphtheria               per …     0
##  3 COUNTRIES ABW   Aruba    2021 MEASLES    Measles                  per …     0
##  4 COUNTRIES ABW   Aruba    2021 MUMPS      Mumps                    per …     0
##  5 COUNTRIES ABW   Aruba    2021 NTETANUS   Neonatal tetanus         per …     0
##  6 COUNTRIES ABW   Aruba    2021 PERTUSSIS  Pertussis                per …     0
##  7 COUNTRIES ABW   Aruba    2021 POLIO      Poliomyelitis            per …     0
##  8 COUNTRIES ABW   Aruba    2021 RUBELLA    Rubella                  per …     0
##  9 COUNTRIES ABW   Aruba    2021 TTETANUS   Total tetanus            per …     0
## 10 COUNTRIES ABW   Aruba    2021 YFEVER     Yellow fever             per …     0
## # ℹ 76,832 more rows
#Load in Case Data

vpd_cases <- read_excel("C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/00_data_raw/VPDs/vpd_reported_cases_2021.xlsx") |> 
  rename(group = GROUP, iso3c =CODE, country = NAME, year = YEAR, disease = DISEASE, disease_desc = DISEASE_DESCRIPTION, cases = CASES) |> 
  filter(group == "COUNTRIES")

#View unique diseases

vpd_cases |> 
  select(disease, disease_desc) |> 
  unique() |> 
  view()

#View unique diseases

vpd_ir |> 
  select(disease, disease_desc) |> 
  unique() |> 
  view()

#No need to keep neonatal tetanus for this analysis, drop and keep total tetanus

vpd_cases <- vpd_cases |> 
  filter(!(disease_desc=="Neonatal tetanus"))

vpd_ir <- vpd_ir |> 
  filter(!(disease_desc=="Neonatal tetanus"))

#Rename "Total tetanus" to just tetanus

vpd_cases <- vpd_cases |> 
  mutate(disease_desc = ifelse(disease_desc == "Total tetanus", "Tetanus", disease_desc))
  
vpd_cases |> 
  select(disease, disease_desc) |> 
  unique() |> 
  view()

vpd_ir <- vpd_ir |> 
  mutate(disease_desc = ifelse(disease_desc == "Total tetanus", "Tetanus", disease_desc))
  
vpd_ir |> 
  select(disease, disease_desc) |> 
  unique() |> 
  view()

#Check missingness

miss_var_summary(vpd_cases)
## # A tibble: 7 × 3
##   variable     n_miss pct_miss
##   <chr>         <int>    <dbl>
## 1 cases         16907     24.8
## 2 group             0      0  
## 3 iso3c             0      0  
## 4 country           0      0  
## 5 year              0      0  
## 6 disease           0      0  
## 7 disease_desc      0      0
vpd_cases |> 
  filter(is.na(cases)) |> 
  select(year) |> 
  unique() |> 
  view()

vpd_cases |> 
  filter(is.na(cases)) |> 
  select(country) |> 
  unique() |> 
  view()

#VPD cases data

vpd_cases
## # A tibble: 68,221 × 7
##    group     iso3c country  year disease    disease_desc                cases
##    <chr>     <chr> <chr>   <dbl> <chr>      <chr>                       <dbl>
##  1 COUNTRIES ABW   Aruba    2021 RUBELLA    Rubella                         0
##  2 COUNTRIES ABW   Aruba    2021 POLIO      Poliomyelitis                   0
##  3 COUNTRIES ABW   Aruba    2021 TTETANUS   Tetanus                         0
##  4 COUNTRIES ABW   Aruba    2021 CRS        Congenital rubella syndrome     0
##  5 COUNTRIES ABW   Aruba    2021 MEASLES    Measles                         0
##  6 COUNTRIES ABW   Aruba    2021 PERTUSSIS  Pertussis                       0
##  7 COUNTRIES ABW   Aruba    2021 YFEVER     Yellow fever                    0
##  8 COUNTRIES ABW   Aruba    2021 DIPHTHERIA Diphtheria                      0
##  9 COUNTRIES ABW   Aruba    2021 MUMPS      Mumps                           0
## 10 COUNTRIES ABW   Aruba    2019 CRS        Congenital rubella syndrome     0
## # ℹ 68,211 more rows

Join country cases and incidence data (Source: WHO VPD Immunization Data). Missingness after the join is relatively the same between cases and ir.

#| echo: false
#| warning: false

#Mutate VPD tables with new unique identifier for joins

vpd_case_key = mutate(vpd_cases,
             id = paste(iso3c, year, disease, sep = '_'))

vpd_case_key
## # A tibble: 68,221 × 8
##    group     iso3c country  year disease    disease_desc             cases id   
##    <chr>     <chr> <chr>   <dbl> <chr>      <chr>                    <dbl> <chr>
##  1 COUNTRIES ABW   Aruba    2021 RUBELLA    Rubella                      0 ABW_…
##  2 COUNTRIES ABW   Aruba    2021 POLIO      Poliomyelitis                0 ABW_…
##  3 COUNTRIES ABW   Aruba    2021 TTETANUS   Tetanus                      0 ABW_…
##  4 COUNTRIES ABW   Aruba    2021 CRS        Congenital rubella synd…     0 ABW_…
##  5 COUNTRIES ABW   Aruba    2021 MEASLES    Measles                      0 ABW_…
##  6 COUNTRIES ABW   Aruba    2021 PERTUSSIS  Pertussis                    0 ABW_…
##  7 COUNTRIES ABW   Aruba    2021 YFEVER     Yellow fever                 0 ABW_…
##  8 COUNTRIES ABW   Aruba    2021 DIPHTHERIA Diphtheria                   0 ABW_…
##  9 COUNTRIES ABW   Aruba    2021 MUMPS      Mumps                        0 ABW_…
## 10 COUNTRIES ABW   Aruba    2019 CRS        Congenital rubella synd…     0 ABW_…
## # ℹ 68,211 more rows
vpd_ir_key = mutate(vpd_ir,
             id = paste(iso3c, year, disease, sep = '_'))

vpd_ir_key
## # A tibble: 68,221 × 9
##    group     iso3c country  year disease    disease_desc       units    ir id   
##    <chr>     <chr> <chr>   <dbl> <chr>      <chr>              <chr> <dbl> <chr>
##  1 COUNTRIES ABW   Aruba    2021 CRS        Congenital rubell… per …     0 ABW_…
##  2 COUNTRIES ABW   Aruba    2021 DIPHTHERIA Diphtheria         per …     0 ABW_…
##  3 COUNTRIES ABW   Aruba    2021 MEASLES    Measles            per …     0 ABW_…
##  4 COUNTRIES ABW   Aruba    2021 MUMPS      Mumps              per …     0 ABW_…
##  5 COUNTRIES ABW   Aruba    2021 PERTUSSIS  Pertussis          per …     0 ABW_…
##  6 COUNTRIES ABW   Aruba    2021 POLIO      Poliomyelitis      per …     0 ABW_…
##  7 COUNTRIES ABW   Aruba    2021 RUBELLA    Rubella            per …     0 ABW_…
##  8 COUNTRIES ABW   Aruba    2021 TTETANUS   Tetanus            per …     0 ABW_…
##  9 COUNTRIES ABW   Aruba    2021 YFEVER     Yellow fever       per …     0 ABW_…
## 10 COUNTRIES ABW   Aruba    2019 CRS        Congenital rubell… per …     0 ABW_…
## # ℹ 68,211 more rows
#Change order of columns to put unique id in front for left join

vpd_case_key <- vpd_case_key[,c(8,1,2,3,4,5,6,7)]

vpd_ir_key <- vpd_ir_key[,c(9,1,2,3,4,5,6,7,8)]

#Left join ir to cases

vpd <- vpd_case_key |> 
          left_join(vpd_ir_key, by = c("id", "group", "iso3c", "country", "year", "disease", "disease_desc"))

#Check missingness

miss_var_summary(vpd)
## # A tibble: 10 × 3
##    variable     n_miss pct_miss
##    <chr>         <int>    <dbl>
##  1 ir            16923     24.8
##  2 cases         16907     24.8
##  3 id                0      0  
##  4 group             0      0  
##  5 iso3c             0      0  
##  6 country           0      0  
##  7 year              0      0  
##  8 disease           0      0  
##  9 disease_desc      0      0  
## 10 units             0      0
vpd
## # A tibble: 68,221 × 10
##    id           group iso3c country  year disease disease_desc cases units    ir
##    <chr>        <chr> <chr> <chr>   <dbl> <chr>   <chr>        <dbl> <chr> <dbl>
##  1 ABW_2021_RU… COUN… ABW   Aruba    2021 RUBELLA Rubella          0 per …     0
##  2 ABW_2021_PO… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0
##  3 ABW_2021_TT… COUN… ABW   Aruba    2021 TTETAN… Tetanus          0 per …     0
##  4 ABW_2021_CRS COUN… ABW   Aruba    2021 CRS     Congenital …     0 per …     0
##  5 ABW_2021_ME… COUN… ABW   Aruba    2021 MEASLES Measles          0 per …     0
##  6 ABW_2021_PE… COUN… ABW   Aruba    2021 PERTUS… Pertussis        0 per …     0
##  7 ABW_2021_YF… COUN… ABW   Aruba    2021 YFEVER  Yellow fever     0 per …     0
##  8 ABW_2021_DI… COUN… ABW   Aruba    2021 DIPHTH… Diphtheria       0 per …     0
##  9 ABW_2021_MU… COUN… ABW   Aruba    2021 MUMPS   Mumps            0 per …     0
## 10 ABW_2019_CRS COUN… ABW   Aruba    2019 CRS     Congenital …     0 per …     0
## # ℹ 68,211 more rows

Now to add VPD immunization coverage (data source: WHO VPD Vaccination Coverage). There is a high rate of missing data in source data, let’s check where it is. It again spans all countries, years, and diseases so we will have to tailor findings and explanations accordingly. We need to take out target coverage and doses and filter on the official collection method to simplify out vaccination coverage data for the least amount of missingness and higher accuracy.

#| echo: false
#| warning: false

#Load in VPD Immunization Coverage

vpd_vax <- read_excel("C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/00_data_raw/VPDs/vpd_vax_coverage_2021.xlsx") |> 
  rename(group = GROUP, iso3c =CODE, country = NAME, year = YEAR, antig = ANTIGEN, antig_desc = ANTIGEN_DESCRIPTION, disease = DISEASE, coverage_cat = COVERAGE_CATEGORY, cov_cat_desc = COVERAGE_CATEGORY_DESCRIPTION, targ_number = TARGET_NUMBER, doses = DOSES, coverage = COVERAGE) |> 
  filter(group == "COUNTRIES")

vpd_vax
## # A tibble: 328,351 × 12
##    group  iso3c country  year antig antig_desc disease coverage_cat cov_cat_desc
##    <chr>  <chr> <chr>   <dbl> <chr> <chr>      <chr>   <chr>        <chr>       
##  1 COUNT… ABW   Aruba    2021 BCG   BCG        TB      ADMIN        Administrat…
##  2 COUNT… ABW   Aruba    2021 BCG   BCG        TB      OFFICIAL     Official co…
##  3 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  4 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  5 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  6 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  7 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  8 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  9 COUNT… ABW   Aruba    2021 DTPC… DTP-conta… DIPTHE… ADMIN        Administrat…
## 10 COUNT… ABW   Aruba    2021 DTPC… DTP-conta… DIPTHE… OFFICIAL     Official co…
## # ℹ 328,341 more rows
## # ℹ 3 more variables: targ_number <dbl>, doses <dbl>, coverage <dbl>
#Check missingness of original data

miss_var_summary(vpd_vax)
## # A tibble: 12 × 3
##    variable     n_miss pct_miss
##    <chr>         <int>    <dbl>
##  1 targ_number  277849     84.6
##  2 doses        277721     84.6
##  3 coverage     140039     42.6
##  4 group             0      0  
##  5 iso3c             0      0  
##  6 country           0      0  
##  7 year              0      0  
##  8 antig             0      0  
##  9 antig_desc        0      0  
## 10 disease           0      0  
## 11 coverage_cat      0      0  
## 12 cov_cat_desc      0      0
vpd_vax |> 
  filter(is.na(coverage) | is.na(doses) | is.na(targ_number)) |> 
  select(year) |> 
  unique() |> 
  view()

vpd_vax |> 
  filter(is.na(coverage) | is.na(doses) | is.na(targ_number)) |> 
  select(country) |> 
  unique() |> 
  view()

vpd_vax |> 
  filter(is.na(coverage) | is.na(doses) | is.na(targ_number)) |> 
  select(disease) |> 
  unique() |> 
  view()

#Mutate VPD vax coverage with new unique identifier for joins

vpd_vax_key = mutate(vpd_vax,
             id = paste(iso3c, year, disease, sep = '_'))

vpd_vax_key
## # A tibble: 328,351 × 13
##    group  iso3c country  year antig antig_desc disease coverage_cat cov_cat_desc
##    <chr>  <chr> <chr>   <dbl> <chr> <chr>      <chr>   <chr>        <chr>       
##  1 COUNT… ABW   Aruba    2021 BCG   BCG        TB      ADMIN        Administrat…
##  2 COUNT… ABW   Aruba    2021 BCG   BCG        TB      OFFICIAL     Official co…
##  3 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  4 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  5 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  6 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  7 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… ADMIN        Administrat…
##  8 COUNT… ABW   Aruba    2021 DIPH… Diphtheri… DIPTHE… OFFICIAL     Official co…
##  9 COUNT… ABW   Aruba    2021 DTPC… DTP-conta… DIPTHE… ADMIN        Administrat…
## 10 COUNT… ABW   Aruba    2021 DTPC… DTP-conta… DIPTHE… OFFICIAL     Official co…
## # ℹ 328,341 more rows
## # ℹ 4 more variables: targ_number <dbl>, doses <dbl>, coverage <dbl>, id <chr>
vpd_vax_key <- vpd_vax_key[,c(13,1,2,3,4,5,6,7,8,9,10,11,12)]

#Look at unique vax & vax/disease match up

vpd_vax_key |> 
  select(antig_desc) |> 
  unique() |> 
  view()

vpd_vax_key |> 
  select(disease, antig_desc) |> 
  unique() |> 
  view()

#Filter down to official coverage, don't need other estimate methods

vpd_vax_key <- vpd_vax_key |> 
  filter((coverage_cat=="OFFICIAL")) |> 
  select(-c(targ_number,doses))

#Join Vax coverage with 

vpd_combo <- vpd |> 
          left_join(vpd_vax_key, by = c("id", "group", "iso3c", "country", "year", "disease"))

vpd_combo
## # A tibble: 78,597 × 15
##    id     group iso3c country  year disease disease_desc cases units    ir antig
##    <chr>  <chr> <chr> <chr>   <dbl> <chr>   <chr>        <dbl> <chr> <dbl> <chr>
##  1 ABW_2… COUN… ABW   Aruba    2021 RUBELLA Rubella          0 per …     0 RCV1 
##  2 ABW_2… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0 IPV1 
##  3 ABW_2… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0 IPV1…
##  4 ABW_2… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0 IPV2 
##  5 ABW_2… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0 IPV2…
##  6 ABW_2… COUN… ABW   Aruba    2021 POLIO   Poliomyelit…     0 per …     0 POL3 
##  7 ABW_2… COUN… ABW   Aruba    2021 TTETAN… Tetanus          0 per …     0 TT2P…
##  8 ABW_2… COUN… ABW   Aruba    2021 TTETAN… Tetanus          0 per …     0 TTCV4
##  9 ABW_2… COUN… ABW   Aruba    2021 TTETAN… Tetanus          0 per …     0 TTCV5
## 10 ABW_2… COUN… ABW   Aruba    2021 TTETAN… Tetanus          0 per …     0 TTCV6
## # ℹ 78,587 more rows
## # ℹ 4 more variables: antig_desc <chr>, coverage_cat <chr>, cov_cat_desc <chr>,
## #   coverage <dbl>
#check missingness

miss_var_summary(vpd_combo)
## # A tibble: 15 × 3
##    variable     n_miss pct_miss
##    <chr>         <int>    <dbl>
##  1 coverage      51979     66.1
##  2 antig         35599     45.3
##  3 antig_desc    35599     45.3
##  4 coverage_cat  35599     45.3
##  5 cov_cat_desc  35599     45.3
##  6 ir            17840     22.7
##  7 cases         17823     22.7
##  8 id                0      0  
##  9 group             0      0  
## 10 iso3c             0      0  
## 11 country           0      0  
## 12 year              0      0  
## 13 disease           0      0  
## 14 disease_desc      0      0  
## 15 units             0      0

Step 4: COVID-19

Load in VPD immunization coverage. (Source: Our World in Data COVID-19). Cases and vaccinations are again missing a significant amount of values in the source data. To join this data to our VPD data we need to convert doses of vaccines given to coverage, this is a rough estimate for two reasons:

  1. COVID-19 doses are not always = to vaccination (depending on person, vaccine type, and timing of pandemic regulations)

  2. This is a rough estimate (similar to administrative method) unlike the official method used for VPDs

#| echo: false
#| warning: false

#Load in Case & vax Coverage Data

covid <- fread("C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/00_data_raw/COVID/owid-covid-data.csv",
  select = c("iso_code","continent","location","date","new_cases","new_deaths","people_fully_vaccinated")) |> 
  filter(!grepl("OWID", iso_code))

covid
##         iso_code continent    location     date new_cases new_deaths
##      1:      AFG      Asia Afghanistan 1/3/2020         0          0
##      2:      AFG      Asia Afghanistan 1/4/2020         0          0
##      3:      AFG      Asia Afghanistan 1/5/2020         0          0
##      4:      AFG      Asia Afghanistan 1/6/2020         0          0
##      5:      AFG      Asia Afghanistan 1/7/2020         0          0
##     ---                                                             
## 280146:      ZWE    Africa    Zimbabwe 4/1/2023         7          0
## 280147:      ZWE    Africa    Zimbabwe 4/2/2023         0          0
## 280148:      ZWE    Africa    Zimbabwe 4/3/2023         6          0
## 280149:      ZWE    Africa    Zimbabwe 4/4/2023         0          0
## 280150:      ZWE    Africa    Zimbabwe 4/5/2023         0          0
##         people_fully_vaccinated
##      1:                    <NA>
##      2:                    <NA>
##      3:                    <NA>
##      4:                    <NA>
##      5:                    <NA>
##     ---                        
## 280146:                    <NA>
## 280147:                    <NA>
## 280148:                    <NA>
## 280149:                    <NA>
## 280150:                    <NA>
#missingness

miss_var_summary(covid)
## # A tibble: 7 × 3
##   variable                n_miss pct_miss
##   <chr>                    <int>    <dbl>
## 1 people_fully_vaccinated 225509    80.5 
## 2 new_cases                 3311     1.18
## 3 new_deaths                3207     1.14
## 4 iso_code                     0     0   
## 5 continent                    0     0   
## 6 location                     0     0   
## 7 date                         0     0
#Need to aggregate cases and vax by Country by Month, Year

covid_date <- covid |> 
  rename(iso3c = iso_code, country = location) |> 
  separate_wider_delim(date, "/", names = c("month","day","year")) |> 
  transform(year = as.numeric(year)) |> 
  filter(month == 12,
         day == 31)

covid_date
##     iso3c     continent                          country month day year
## 1     AFG          Asia                      Afghanistan    12  31 2020
## 2     AFG          Asia                      Afghanistan    12  31 2021
## 3     AFG          Asia                      Afghanistan    12  31 2022
## 4     ALB        Europe                          Albania    12  31 2020
## 5     ALB        Europe                          Albania    12  31 2021
## 6     ALB        Europe                          Albania    12  31 2022
## 7     DZA        Africa                          Algeria    12  31 2020
## 8     DZA        Africa                          Algeria    12  31 2021
## 9     DZA        Africa                          Algeria    12  31 2022
## 10    ASM       Oceania                   American Samoa    12  31 2020
## 11    ASM       Oceania                   American Samoa    12  31 2021
## 12    ASM       Oceania                   American Samoa    12  31 2022
## 13    AND        Europe                          Andorra    12  31 2020
## 14    AND        Europe                          Andorra    12  31 2021
## 15    AND        Europe                          Andorra    12  31 2022
## 16    AGO        Africa                           Angola    12  31 2020
## 17    AGO        Africa                           Angola    12  31 2021
## 18    AGO        Africa                           Angola    12  31 2022
## 19    AIA North America                         Anguilla    12  31 2020
## 20    AIA North America                         Anguilla    12  31 2021
## 21    AIA North America                         Anguilla    12  31 2022
## 22    ATG North America              Antigua and Barbuda    12  31 2020
## 23    ATG North America              Antigua and Barbuda    12  31 2021
## 24    ATG North America              Antigua and Barbuda    12  31 2022
## 25    ARG South America                        Argentina    12  31 2020
## 26    ARG South America                        Argentina    12  31 2021
## 27    ARG South America                        Argentina    12  31 2022
## 28    ARM          Asia                          Armenia    12  31 2020
## 29    ARM          Asia                          Armenia    12  31 2021
## 30    ARM          Asia                          Armenia    12  31 2022
## 31    ABW North America                            Aruba    12  31 2020
## 32    ABW North America                            Aruba    12  31 2021
## 33    ABW North America                            Aruba    12  31 2022
## 34    AUS       Oceania                        Australia    12  31 2020
## 35    AUS       Oceania                        Australia    12  31 2021
## 36    AUS       Oceania                        Australia    12  31 2022
## 37    AUT        Europe                          Austria    12  31 2020
## 38    AUT        Europe                          Austria    12  31 2021
## 39    AUT        Europe                          Austria    12  31 2022
## 40    AZE          Asia                       Azerbaijan    12  31 2020
## 41    AZE          Asia                       Azerbaijan    12  31 2021
## 42    AZE          Asia                       Azerbaijan    12  31 2022
## 43    BHS North America                          Bahamas    12  31 2020
## 44    BHS North America                          Bahamas    12  31 2021
## 45    BHS North America                          Bahamas    12  31 2022
## 46    BHR          Asia                          Bahrain    12  31 2020
## 47    BHR          Asia                          Bahrain    12  31 2021
## 48    BHR          Asia                          Bahrain    12  31 2022
## 49    BGD          Asia                       Bangladesh    12  31 2020
## 50    BGD          Asia                       Bangladesh    12  31 2021
## 51    BGD          Asia                       Bangladesh    12  31 2022
## 52    BRB North America                         Barbados    12  31 2020
## 53    BRB North America                         Barbados    12  31 2021
## 54    BRB North America                         Barbados    12  31 2022
## 55    BLR        Europe                          Belarus    12  31 2020
## 56    BLR        Europe                          Belarus    12  31 2021
## 57    BLR        Europe                          Belarus    12  31 2022
## 58    BEL        Europe                          Belgium    12  31 2020
## 59    BEL        Europe                          Belgium    12  31 2021
## 60    BEL        Europe                          Belgium    12  31 2022
## 61    BLZ North America                           Belize    12  31 2020
## 62    BLZ North America                           Belize    12  31 2021
## 63    BLZ North America                           Belize    12  31 2022
## 64    BEN        Africa                            Benin    12  31 2020
## 65    BEN        Africa                            Benin    12  31 2021
## 66    BEN        Africa                            Benin    12  31 2022
## 67    BMU North America                          Bermuda    12  31 2020
## 68    BMU North America                          Bermuda    12  31 2021
## 69    BMU North America                          Bermuda    12  31 2022
## 70    BTN          Asia                           Bhutan    12  31 2020
## 71    BTN          Asia                           Bhutan    12  31 2021
## 72    BTN          Asia                           Bhutan    12  31 2022
## 73    BOL South America                          Bolivia    12  31 2020
## 74    BOL South America                          Bolivia    12  31 2021
## 75    BOL South America                          Bolivia    12  31 2022
## 76    BES North America  Bonaire Sint Eustatius and Saba    12  31 2020
## 77    BES North America  Bonaire Sint Eustatius and Saba    12  31 2021
## 78    BES North America  Bonaire Sint Eustatius and Saba    12  31 2022
## 79    BIH        Europe           Bosnia and Herzegovina    12  31 2020
## 80    BIH        Europe           Bosnia and Herzegovina    12  31 2021
## 81    BIH        Europe           Bosnia and Herzegovina    12  31 2022
## 82    BWA        Africa                         Botswana    12  31 2020
## 83    BWA        Africa                         Botswana    12  31 2021
## 84    BWA        Africa                         Botswana    12  31 2022
## 85    BRA South America                           Brazil    12  31 2020
## 86    BRA South America                           Brazil    12  31 2021
## 87    BRA South America                           Brazil    12  31 2022
## 88    VGB North America           British Virgin Islands    12  31 2020
## 89    VGB North America           British Virgin Islands    12  31 2021
## 90    VGB North America           British Virgin Islands    12  31 2022
## 91    BRN          Asia                           Brunei    12  31 2020
## 92    BRN          Asia                           Brunei    12  31 2021
## 93    BRN          Asia                           Brunei    12  31 2022
## 94    BGR        Europe                         Bulgaria    12  31 2020
## 95    BGR        Europe                         Bulgaria    12  31 2021
## 96    BGR        Europe                         Bulgaria    12  31 2022
## 97    BFA        Africa                     Burkina Faso    12  31 2020
## 98    BFA        Africa                     Burkina Faso    12  31 2021
## 99    BFA        Africa                     Burkina Faso    12  31 2022
## 100   BDI        Africa                          Burundi    12  31 2020
## 101   BDI        Africa                          Burundi    12  31 2021
## 102   BDI        Africa                          Burundi    12  31 2022
## 103   KHM          Asia                         Cambodia    12  31 2020
## 104   KHM          Asia                         Cambodia    12  31 2021
## 105   KHM          Asia                         Cambodia    12  31 2022
## 106   CMR        Africa                         Cameroon    12  31 2020
## 107   CMR        Africa                         Cameroon    12  31 2021
## 108   CMR        Africa                         Cameroon    12  31 2022
## 109   CAN North America                           Canada    12  31 2020
## 110   CAN North America                           Canada    12  31 2021
## 111   CAN North America                           Canada    12  31 2022
## 112   CPV        Africa                       Cape Verde    12  31 2020
## 113   CPV        Africa                       Cape Verde    12  31 2021
## 114   CPV        Africa                       Cape Verde    12  31 2022
## 115   CYM North America                   Cayman Islands    12  31 2020
## 116   CYM North America                   Cayman Islands    12  31 2021
## 117   CYM North America                   Cayman Islands    12  31 2022
## 118   CAF        Africa         Central African Republic    12  31 2020
## 119   CAF        Africa         Central African Republic    12  31 2021
## 120   CAF        Africa         Central African Republic    12  31 2022
## 121   TCD        Africa                             Chad    12  31 2020
## 122   TCD        Africa                             Chad    12  31 2021
## 123   TCD        Africa                             Chad    12  31 2022
## 124   CHL South America                            Chile    12  31 2020
## 125   CHL South America                            Chile    12  31 2021
## 126   CHL South America                            Chile    12  31 2022
## 127   CHN          Asia                            China    12  31 2020
## 128   CHN          Asia                            China    12  31 2021
## 129   CHN          Asia                            China    12  31 2022
## 130   COL South America                         Colombia    12  31 2020
## 131   COL South America                         Colombia    12  31 2021
## 132   COL South America                         Colombia    12  31 2022
## 133   COM        Africa                          Comoros    12  31 2020
## 134   COM        Africa                          Comoros    12  31 2021
## 135   COM        Africa                          Comoros    12  31 2022
## 136   COG        Africa                            Congo    12  31 2020
## 137   COG        Africa                            Congo    12  31 2021
## 138   COG        Africa                            Congo    12  31 2022
## 139   COK       Oceania                     Cook Islands    12  31 2020
## 140   COK       Oceania                     Cook Islands    12  31 2021
## 141   COK       Oceania                     Cook Islands    12  31 2022
## 142   CRI North America                       Costa Rica    12  31 2020
## 143   CRI North America                       Costa Rica    12  31 2021
## 144   CRI North America                       Costa Rica    12  31 2022
## 145   CIV        Africa                    Cote d'Ivoire    12  31 2020
## 146   CIV        Africa                    Cote d'Ivoire    12  31 2021
## 147   CIV        Africa                    Cote d'Ivoire    12  31 2022
## 148   HRV        Europe                          Croatia    12  31 2020
## 149   HRV        Europe                          Croatia    12  31 2021
## 150   HRV        Europe                          Croatia    12  31 2022
## 151   CUB North America                             Cuba    12  31 2020
## 152   CUB North America                             Cuba    12  31 2021
## 153   CUB North America                             Cuba    12  31 2022
## 154   CUW North America                          Curacao    12  31 2020
## 155   CUW North America                          Curacao    12  31 2021
## 156   CUW North America                          Curacao    12  31 2022
## 157   CYP        Europe                           Cyprus    12  31 2020
## 158   CYP        Europe                           Cyprus    12  31 2021
## 159   CYP        Europe                           Cyprus    12  31 2022
## 160   CZE        Europe                          Czechia    12  31 2020
## 161   CZE        Europe                          Czechia    12  31 2021
## 162   CZE        Europe                          Czechia    12  31 2022
## 163   COD        Africa     Democratic Republic of Congo    12  31 2020
## 164   COD        Africa     Democratic Republic of Congo    12  31 2021
## 165   COD        Africa     Democratic Republic of Congo    12  31 2022
## 166   DNK        Europe                          Denmark    12  31 2020
## 167   DNK        Europe                          Denmark    12  31 2021
## 168   DNK        Europe                          Denmark    12  31 2022
## 169   DJI        Africa                         Djibouti    12  31 2020
## 170   DJI        Africa                         Djibouti    12  31 2021
## 171   DJI        Africa                         Djibouti    12  31 2022
## 172   DMA North America                         Dominica    12  31 2020
## 173   DMA North America                         Dominica    12  31 2021
## 174   DMA North America                         Dominica    12  31 2022
## 175   DOM North America               Dominican Republic    12  31 2020
## 176   DOM North America               Dominican Republic    12  31 2021
## 177   DOM North America               Dominican Republic    12  31 2022
## 178   ECU South America                          Ecuador    12  31 2020
## 179   ECU South America                          Ecuador    12  31 2021
## 180   ECU South America                          Ecuador    12  31 2022
## 181   EGY        Africa                            Egypt    12  31 2020
## 182   EGY        Africa                            Egypt    12  31 2021
## 183   EGY        Africa                            Egypt    12  31 2022
## 184   SLV North America                      El Salvador    12  31 2020
## 185   SLV North America                      El Salvador    12  31 2021
## 186   SLV North America                      El Salvador    12  31 2022
## 187   GNQ        Africa                Equatorial Guinea    12  31 2020
## 188   GNQ        Africa                Equatorial Guinea    12  31 2021
## 189   GNQ        Africa                Equatorial Guinea    12  31 2022
## 190   ERI        Africa                          Eritrea    12  31 2020
## 191   ERI        Africa                          Eritrea    12  31 2021
## 192   ERI        Africa                          Eritrea    12  31 2022
## 193   EST        Europe                          Estonia    12  31 2020
## 194   EST        Europe                          Estonia    12  31 2021
## 195   EST        Europe                          Estonia    12  31 2022
## 196   SWZ        Africa                         Eswatini    12  31 2020
## 197   SWZ        Africa                         Eswatini    12  31 2021
## 198   SWZ        Africa                         Eswatini    12  31 2022
## 199   ETH        Africa                         Ethiopia    12  31 2020
## 200   ETH        Africa                         Ethiopia    12  31 2021
## 201   ETH        Africa                         Ethiopia    12  31 2022
## 202   FRO        Europe                   Faeroe Islands    12  31 2020
## 203   FRO        Europe                   Faeroe Islands    12  31 2021
## 204   FRO        Europe                   Faeroe Islands    12  31 2022
## 205   FLK South America                 Falkland Islands    12  31 2020
## 206   FLK South America                 Falkland Islands    12  31 2021
## 207   FLK South America                 Falkland Islands    12  31 2022
## 208   FJI       Oceania                             Fiji    12  31 2020
## 209   FJI       Oceania                             Fiji    12  31 2021
## 210   FJI       Oceania                             Fiji    12  31 2022
## 211   FIN        Europe                          Finland    12  31 2020
## 212   FIN        Europe                          Finland    12  31 2021
## 213   FIN        Europe                          Finland    12  31 2022
## 214   FRA        Europe                           France    12  31 2020
## 215   FRA        Europe                           France    12  31 2021
## 216   FRA        Europe                           France    12  31 2022
## 217   GUF South America                    French Guiana    12  31 2020
## 218   GUF South America                    French Guiana    12  31 2021
## 219   GUF South America                    French Guiana    12  31 2022
## 220   PYF       Oceania                 French Polynesia    12  31 2020
## 221   PYF       Oceania                 French Polynesia    12  31 2021
## 222   PYF       Oceania                 French Polynesia    12  31 2022
## 223   GAB        Africa                            Gabon    12  31 2020
## 224   GAB        Africa                            Gabon    12  31 2021
## 225   GAB        Africa                            Gabon    12  31 2022
## 226   GMB        Africa                           Gambia    12  31 2020
## 227   GMB        Africa                           Gambia    12  31 2021
## 228   GMB        Africa                           Gambia    12  31 2022
## 229   GEO          Asia                          Georgia    12  31 2020
## 230   GEO          Asia                          Georgia    12  31 2021
## 231   GEO          Asia                          Georgia    12  31 2022
## 232   DEU        Europe                          Germany    12  31 2020
## 233   DEU        Europe                          Germany    12  31 2021
## 234   DEU        Europe                          Germany    12  31 2022
## 235   GHA        Africa                            Ghana    12  31 2020
## 236   GHA        Africa                            Ghana    12  31 2021
## 237   GHA        Africa                            Ghana    12  31 2022
## 238   GIB        Europe                        Gibraltar    12  31 2020
## 239   GIB        Europe                        Gibraltar    12  31 2021
## 240   GIB        Europe                        Gibraltar    12  31 2022
## 241   GRC        Europe                           Greece    12  31 2020
## 242   GRC        Europe                           Greece    12  31 2021
## 243   GRC        Europe                           Greece    12  31 2022
## 244   GRL North America                        Greenland    12  31 2020
## 245   GRL North America                        Greenland    12  31 2021
## 246   GRL North America                        Greenland    12  31 2022
## 247   GRD North America                          Grenada    12  31 2020
## 248   GRD North America                          Grenada    12  31 2021
## 249   GRD North America                          Grenada    12  31 2022
## 250   GLP North America                       Guadeloupe    12  31 2020
## 251   GLP North America                       Guadeloupe    12  31 2021
## 252   GLP North America                       Guadeloupe    12  31 2022
## 253   GUM       Oceania                             Guam    12  31 2020
## 254   GUM       Oceania                             Guam    12  31 2021
## 255   GUM       Oceania                             Guam    12  31 2022
## 256   GTM North America                        Guatemala    12  31 2020
## 257   GTM North America                        Guatemala    12  31 2021
## 258   GTM North America                        Guatemala    12  31 2022
## 259   GGY        Europe                         Guernsey    12  31 2020
## 260   GGY        Europe                         Guernsey    12  31 2021
## 261   GGY        Europe                         Guernsey    12  31 2022
## 262   GIN        Africa                           Guinea    12  31 2020
## 263   GIN        Africa                           Guinea    12  31 2021
## 264   GIN        Africa                           Guinea    12  31 2022
## 265   GNB        Africa                    Guinea-Bissau    12  31 2020
## 266   GNB        Africa                    Guinea-Bissau    12  31 2021
## 267   GNB        Africa                    Guinea-Bissau    12  31 2022
## 268   GUY South America                           Guyana    12  31 2020
## 269   GUY South America                           Guyana    12  31 2021
## 270   GUY South America                           Guyana    12  31 2022
## 271   HTI North America                            Haiti    12  31 2020
## 272   HTI North America                            Haiti    12  31 2021
## 273   HTI North America                            Haiti    12  31 2022
## 274   HND North America                         Honduras    12  31 2020
## 275   HND North America                         Honduras    12  31 2021
## 276   HND North America                         Honduras    12  31 2022
## 277   HKG          Asia                        Hong Kong    12  31 2020
## 278   HKG          Asia                        Hong Kong    12  31 2021
## 279   HKG          Asia                        Hong Kong    12  31 2022
## 280   HUN        Europe                          Hungary    12  31 2020
## 281   HUN        Europe                          Hungary    12  31 2021
## 282   HUN        Europe                          Hungary    12  31 2022
## 283   ISL        Europe                          Iceland    12  31 2020
## 284   ISL        Europe                          Iceland    12  31 2021
## 285   ISL        Europe                          Iceland    12  31 2022
## 286   IND          Asia                            India    12  31 2020
## 287   IND          Asia                            India    12  31 2021
## 288   IND          Asia                            India    12  31 2022
## 289   IDN          Asia                        Indonesia    12  31 2020
## 290   IDN          Asia                        Indonesia    12  31 2021
## 291   IDN          Asia                        Indonesia    12  31 2022
## 292   IRN          Asia                             Iran    12  31 2020
## 293   IRN          Asia                             Iran    12  31 2021
## 294   IRN          Asia                             Iran    12  31 2022
## 295   IRQ          Asia                             Iraq    12  31 2020
## 296   IRQ          Asia                             Iraq    12  31 2021
## 297   IRQ          Asia                             Iraq    12  31 2022
## 298   IRL        Europe                          Ireland    12  31 2020
## 299   IRL        Europe                          Ireland    12  31 2021
## 300   IRL        Europe                          Ireland    12  31 2022
## 301   IMN        Europe                      Isle of Man    12  31 2020
## 302   IMN        Europe                      Isle of Man    12  31 2021
## 303   IMN        Europe                      Isle of Man    12  31 2022
## 304   ISR          Asia                           Israel    12  31 2020
## 305   ISR          Asia                           Israel    12  31 2021
## 306   ISR          Asia                           Israel    12  31 2022
## 307   ITA        Europe                            Italy    12  31 2020
## 308   ITA        Europe                            Italy    12  31 2021
## 309   ITA        Europe                            Italy    12  31 2022
## 310   JAM North America                          Jamaica    12  31 2020
## 311   JAM North America                          Jamaica    12  31 2021
## 312   JAM North America                          Jamaica    12  31 2022
## 313   JPN          Asia                            Japan    12  31 2020
## 314   JPN          Asia                            Japan    12  31 2021
## 315   JPN          Asia                            Japan    12  31 2022
## 316   JEY        Europe                           Jersey    12  31 2020
## 317   JEY        Europe                           Jersey    12  31 2021
## 318   JEY        Europe                           Jersey    12  31 2022
## 319   JOR          Asia                           Jordan    12  31 2020
## 320   JOR          Asia                           Jordan    12  31 2021
## 321   JOR          Asia                           Jordan    12  31 2022
## 322   KAZ          Asia                       Kazakhstan    12  31 2020
## 323   KAZ          Asia                       Kazakhstan    12  31 2021
## 324   KAZ          Asia                       Kazakhstan    12  31 2022
## 325   KEN        Africa                            Kenya    12  31 2020
## 326   KEN        Africa                            Kenya    12  31 2021
## 327   KEN        Africa                            Kenya    12  31 2022
## 328   KIR       Oceania                         Kiribati    12  31 2020
## 329   KIR       Oceania                         Kiribati    12  31 2021
## 330   KIR       Oceania                         Kiribati    12  31 2022
## 331   KWT          Asia                           Kuwait    12  31 2020
## 332   KWT          Asia                           Kuwait    12  31 2021
## 333   KWT          Asia                           Kuwait    12  31 2022
## 334   KGZ          Asia                       Kyrgyzstan    12  31 2020
## 335   KGZ          Asia                       Kyrgyzstan    12  31 2021
## 336   KGZ          Asia                       Kyrgyzstan    12  31 2022
## 337   LAO          Asia                             Laos    12  31 2020
## 338   LAO          Asia                             Laos    12  31 2021
## 339   LAO          Asia                             Laos    12  31 2022
## 340   LVA        Europe                           Latvia    12  31 2020
## 341   LVA        Europe                           Latvia    12  31 2021
## 342   LVA        Europe                           Latvia    12  31 2022
## 343   LBN          Asia                          Lebanon    12  31 2020
## 344   LBN          Asia                          Lebanon    12  31 2021
## 345   LBN          Asia                          Lebanon    12  31 2022
## 346   LSO        Africa                          Lesotho    12  31 2020
## 347   LSO        Africa                          Lesotho    12  31 2021
## 348   LSO        Africa                          Lesotho    12  31 2022
## 349   LBR        Africa                          Liberia    12  31 2020
## 350   LBR        Africa                          Liberia    12  31 2021
## 351   LBR        Africa                          Liberia    12  31 2022
## 352   LBY        Africa                            Libya    12  31 2020
## 353   LBY        Africa                            Libya    12  31 2021
## 354   LBY        Africa                            Libya    12  31 2022
## 355   LIE        Europe                    Liechtenstein    12  31 2020
## 356   LIE        Europe                    Liechtenstein    12  31 2021
## 357   LIE        Europe                    Liechtenstein    12  31 2022
## 358   LTU        Europe                        Lithuania    12  31 2020
## 359   LTU        Europe                        Lithuania    12  31 2021
## 360   LTU        Europe                        Lithuania    12  31 2022
## 361   LUX        Europe                       Luxembourg    12  31 2020
## 362   LUX        Europe                       Luxembourg    12  31 2021
## 363   LUX        Europe                       Luxembourg    12  31 2022
## 364   MAC          Asia                            Macao    12  31 2021
## 365   MAC          Asia                            Macao    12  31 2022
## 366   MDG        Africa                       Madagascar    12  31 2020
## 367   MDG        Africa                       Madagascar    12  31 2021
## 368   MDG        Africa                       Madagascar    12  31 2022
## 369   MWI        Africa                           Malawi    12  31 2020
## 370   MWI        Africa                           Malawi    12  31 2021
## 371   MWI        Africa                           Malawi    12  31 2022
## 372   MYS          Asia                         Malaysia    12  31 2020
## 373   MYS          Asia                         Malaysia    12  31 2021
## 374   MYS          Asia                         Malaysia    12  31 2022
## 375   MDV          Asia                         Maldives    12  31 2020
## 376   MDV          Asia                         Maldives    12  31 2021
## 377   MDV          Asia                         Maldives    12  31 2022
## 378   MLI        Africa                             Mali    12  31 2020
## 379   MLI        Africa                             Mali    12  31 2021
## 380   MLI        Africa                             Mali    12  31 2022
## 381   MLT        Europe                            Malta    12  31 2020
## 382   MLT        Europe                            Malta    12  31 2021
## 383   MLT        Europe                            Malta    12  31 2022
## 384   MHL       Oceania                 Marshall Islands    12  31 2020
## 385   MHL       Oceania                 Marshall Islands    12  31 2021
## 386   MHL       Oceania                 Marshall Islands    12  31 2022
## 387   MTQ North America                       Martinique    12  31 2020
## 388   MTQ North America                       Martinique    12  31 2021
## 389   MTQ North America                       Martinique    12  31 2022
## 390   MRT        Africa                       Mauritania    12  31 2020
## 391   MRT        Africa                       Mauritania    12  31 2021
## 392   MRT        Africa                       Mauritania    12  31 2022
## 393   MUS        Africa                        Mauritius    12  31 2020
## 394   MUS        Africa                        Mauritius    12  31 2021
## 395   MUS        Africa                        Mauritius    12  31 2022
## 396   MYT        Africa                          Mayotte    12  31 2020
## 397   MYT        Africa                          Mayotte    12  31 2021
## 398   MYT        Africa                          Mayotte    12  31 2022
## 399   MEX North America                           Mexico    12  31 2020
## 400   MEX North America                           Mexico    12  31 2021
## 401   MEX North America                           Mexico    12  31 2022
## 402   FSM       Oceania             Micronesia (country)    12  31 2020
## 403   FSM       Oceania             Micronesia (country)    12  31 2021
## 404   FSM       Oceania             Micronesia (country)    12  31 2022
## 405   MDA        Europe                          Moldova    12  31 2020
## 406   MDA        Europe                          Moldova    12  31 2021
## 407   MDA        Europe                          Moldova    12  31 2022
## 408   MCO        Europe                           Monaco    12  31 2020
## 409   MCO        Europe                           Monaco    12  31 2021
## 410   MCO        Europe                           Monaco    12  31 2022
## 411   MNG          Asia                         Mongolia    12  31 2020
## 412   MNG          Asia                         Mongolia    12  31 2021
## 413   MNG          Asia                         Mongolia    12  31 2022
## 414   MNE        Europe                       Montenegro    12  31 2020
## 415   MNE        Europe                       Montenegro    12  31 2021
## 416   MNE        Europe                       Montenegro    12  31 2022
## 417   MSR North America                       Montserrat    12  31 2020
## 418   MSR North America                       Montserrat    12  31 2021
## 419   MSR North America                       Montserrat    12  31 2022
## 420   MAR        Africa                          Morocco    12  31 2020
## 421   MAR        Africa                          Morocco    12  31 2021
## 422   MAR        Africa                          Morocco    12  31 2022
## 423   MOZ        Africa                       Mozambique    12  31 2020
## 424   MOZ        Africa                       Mozambique    12  31 2021
## 425   MOZ        Africa                       Mozambique    12  31 2022
## 426   MMR          Asia                          Myanmar    12  31 2020
## 427   MMR          Asia                          Myanmar    12  31 2021
## 428   MMR          Asia                          Myanmar    12  31 2022
## 429   NAM        Africa                          Namibia    12  31 2020
## 430   NAM        Africa                          Namibia    12  31 2021
## 431   NAM        Africa                          Namibia    12  31 2022
## 432   NRU       Oceania                            Nauru    12  31 2020
## 433   NRU       Oceania                            Nauru    12  31 2021
## 434   NRU       Oceania                            Nauru    12  31 2022
## 435   NPL          Asia                            Nepal    12  31 2020
## 436   NPL          Asia                            Nepal    12  31 2021
## 437   NPL          Asia                            Nepal    12  31 2022
## 438   NLD        Europe                      Netherlands    12  31 2020
## 439   NLD        Europe                      Netherlands    12  31 2021
## 440   NLD        Europe                      Netherlands    12  31 2022
## 441   NCL       Oceania                    New Caledonia    12  31 2020
## 442   NCL       Oceania                    New Caledonia    12  31 2021
## 443   NCL       Oceania                    New Caledonia    12  31 2022
## 444   NZL       Oceania                      New Zealand    12  31 2020
## 445   NZL       Oceania                      New Zealand    12  31 2021
## 446   NZL       Oceania                      New Zealand    12  31 2022
## 447   NIC North America                        Nicaragua    12  31 2020
## 448   NIC North America                        Nicaragua    12  31 2021
## 449   NIC North America                        Nicaragua    12  31 2022
## 450   NER        Africa                            Niger    12  31 2020
## 451   NER        Africa                            Niger    12  31 2021
## 452   NER        Africa                            Niger    12  31 2022
## 453   NGA        Africa                          Nigeria    12  31 2020
## 454   NGA        Africa                          Nigeria    12  31 2021
## 455   NGA        Africa                          Nigeria    12  31 2022
## 456   NIU       Oceania                             Niue    12  31 2020
## 457   NIU       Oceania                             Niue    12  31 2021
## 458   NIU       Oceania                             Niue    12  31 2022
## 459   PRK          Asia                      North Korea    12  31 2020
## 460   PRK          Asia                      North Korea    12  31 2021
## 461   PRK          Asia                      North Korea    12  31 2022
## 462   MKD        Europe                  North Macedonia    12  31 2020
## 463   MKD        Europe                  North Macedonia    12  31 2021
## 464   MKD        Europe                  North Macedonia    12  31 2022
## 465   MNP       Oceania         Northern Mariana Islands    12  31 2020
## 466   MNP       Oceania         Northern Mariana Islands    12  31 2021
## 467   MNP       Oceania         Northern Mariana Islands    12  31 2022
## 468   NOR        Europe                           Norway    12  31 2020
## 469   NOR        Europe                           Norway    12  31 2021
## 470   NOR        Europe                           Norway    12  31 2022
## 471   OMN          Asia                             Oman    12  31 2020
## 472   OMN          Asia                             Oman    12  31 2021
## 473   OMN          Asia                             Oman    12  31 2022
## 474   PAK          Asia                         Pakistan    12  31 2020
## 475   PAK          Asia                         Pakistan    12  31 2021
## 476   PAK          Asia                         Pakistan    12  31 2022
## 477   PLW       Oceania                            Palau    12  31 2020
## 478   PLW       Oceania                            Palau    12  31 2021
## 479   PLW       Oceania                            Palau    12  31 2022
## 480   PSE          Asia                        Palestine    12  31 2020
## 481   PSE          Asia                        Palestine    12  31 2021
## 482   PSE          Asia                        Palestine    12  31 2022
## 483   PAN North America                           Panama    12  31 2020
## 484   PAN North America                           Panama    12  31 2021
## 485   PAN North America                           Panama    12  31 2022
## 486   PNG       Oceania                 Papua New Guinea    12  31 2020
## 487   PNG       Oceania                 Papua New Guinea    12  31 2021
## 488   PNG       Oceania                 Papua New Guinea    12  31 2022
## 489   PRY South America                         Paraguay    12  31 2020
## 490   PRY South America                         Paraguay    12  31 2021
## 491   PRY South America                         Paraguay    12  31 2022
## 492   PER South America                             Peru    12  31 2020
## 493   PER South America                             Peru    12  31 2021
## 494   PER South America                             Peru    12  31 2022
## 495   PHL          Asia                      Philippines    12  31 2020
## 496   PHL          Asia                      Philippines    12  31 2021
## 497   PHL          Asia                      Philippines    12  31 2022
## 498   PCN       Oceania                         Pitcairn    12  31 2020
## 499   PCN       Oceania                         Pitcairn    12  31 2021
## 500   PCN       Oceania                         Pitcairn    12  31 2022
## 501   POL        Europe                           Poland    12  31 2020
## 502   POL        Europe                           Poland    12  31 2021
## 503   POL        Europe                           Poland    12  31 2022
## 504   PRT        Europe                         Portugal    12  31 2020
## 505   PRT        Europe                         Portugal    12  31 2021
## 506   PRT        Europe                         Portugal    12  31 2022
## 507   PRI North America                      Puerto Rico    12  31 2020
## 508   PRI North America                      Puerto Rico    12  31 2021
## 509   PRI North America                      Puerto Rico    12  31 2022
## 510   QAT          Asia                            Qatar    12  31 2020
## 511   QAT          Asia                            Qatar    12  31 2021
## 512   QAT          Asia                            Qatar    12  31 2022
## 513   REU        Africa                          Reunion    12  31 2020
## 514   REU        Africa                          Reunion    12  31 2021
## 515   REU        Africa                          Reunion    12  31 2022
## 516   ROU        Europe                          Romania    12  31 2020
## 517   ROU        Europe                          Romania    12  31 2021
## 518   ROU        Europe                          Romania    12  31 2022
## 519   RUS        Europe                           Russia    12  31 2020
## 520   RUS        Europe                           Russia    12  31 2021
## 521   RUS        Europe                           Russia    12  31 2022
## 522   RWA        Africa                           Rwanda    12  31 2020
## 523   RWA        Africa                           Rwanda    12  31 2021
## 524   RWA        Africa                           Rwanda    12  31 2022
## 525   BLM North America                 Saint Barthelemy    12  31 2020
## 526   BLM North America                 Saint Barthelemy    12  31 2021
## 527   BLM North America                 Saint Barthelemy    12  31 2022
## 528   SHN        Africa                     Saint Helena    12  31 2020
## 529   SHN        Africa                     Saint Helena    12  31 2021
## 530   SHN        Africa                     Saint Helena    12  31 2022
## 531   KNA North America            Saint Kitts and Nevis    12  31 2020
## 532   KNA North America            Saint Kitts and Nevis    12  31 2021
## 533   KNA North America            Saint Kitts and Nevis    12  31 2022
## 534   LCA North America                      Saint Lucia    12  31 2020
## 535   LCA North America                      Saint Lucia    12  31 2021
## 536   LCA North America                      Saint Lucia    12  31 2022
## 537   MAF North America       Saint Martin (French part)    12  31 2020
## 538   MAF North America       Saint Martin (French part)    12  31 2021
## 539   MAF North America       Saint Martin (French part)    12  31 2022
## 540   SPM North America        Saint Pierre and Miquelon    12  31 2020
## 541   SPM North America        Saint Pierre and Miquelon    12  31 2021
## 542   SPM North America        Saint Pierre and Miquelon    12  31 2022
## 543   VCT North America Saint Vincent and the Grenadines    12  31 2020
## 544   VCT North America Saint Vincent and the Grenadines    12  31 2021
## 545   VCT North America Saint Vincent and the Grenadines    12  31 2022
## 546   WSM       Oceania                            Samoa    12  31 2020
## 547   WSM       Oceania                            Samoa    12  31 2021
## 548   WSM       Oceania                            Samoa    12  31 2022
## 549   SMR        Europe                       San Marino    12  31 2020
## 550   SMR        Europe                       San Marino    12  31 2021
## 551   SMR        Europe                       San Marino    12  31 2022
## 552   STP        Africa            Sao Tome and Principe    12  31 2020
## 553   STP        Africa            Sao Tome and Principe    12  31 2021
## 554   STP        Africa            Sao Tome and Principe    12  31 2022
## 555   SAU          Asia                     Saudi Arabia    12  31 2020
## 556   SAU          Asia                     Saudi Arabia    12  31 2021
## 557   SAU          Asia                     Saudi Arabia    12  31 2022
## 558   SEN        Africa                          Senegal    12  31 2020
## 559   SEN        Africa                          Senegal    12  31 2021
## 560   SEN        Africa                          Senegal    12  31 2022
## 561   SRB        Europe                           Serbia    12  31 2020
## 562   SRB        Europe                           Serbia    12  31 2021
## 563   SRB        Europe                           Serbia    12  31 2022
## 564   SYC        Africa                       Seychelles    12  31 2020
## 565   SYC        Africa                       Seychelles    12  31 2021
## 566   SYC        Africa                       Seychelles    12  31 2022
## 567   SLE        Africa                     Sierra Leone    12  31 2020
## 568   SLE        Africa                     Sierra Leone    12  31 2021
## 569   SLE        Africa                     Sierra Leone    12  31 2022
## 570   SGP          Asia                        Singapore    12  31 2020
## 571   SGP          Asia                        Singapore    12  31 2021
## 572   SGP          Asia                        Singapore    12  31 2022
## 573   SXM North America        Sint Maarten (Dutch part)    12  31 2020
## 574   SXM North America        Sint Maarten (Dutch part)    12  31 2021
## 575   SXM North America        Sint Maarten (Dutch part)    12  31 2022
## 576   SVK        Europe                         Slovakia    12  31 2020
## 577   SVK        Europe                         Slovakia    12  31 2021
## 578   SVK        Europe                         Slovakia    12  31 2022
## 579   SVN        Europe                         Slovenia    12  31 2020
## 580   SVN        Europe                         Slovenia    12  31 2021
## 581   SVN        Europe                         Slovenia    12  31 2022
## 582   SLB       Oceania                  Solomon Islands    12  31 2020
## 583   SLB       Oceania                  Solomon Islands    12  31 2021
## 584   SLB       Oceania                  Solomon Islands    12  31 2022
## 585   SOM        Africa                          Somalia    12  31 2020
## 586   SOM        Africa                          Somalia    12  31 2021
## 587   SOM        Africa                          Somalia    12  31 2022
## 588   ZAF        Africa                     South Africa    12  31 2020
## 589   ZAF        Africa                     South Africa    12  31 2021
## 590   ZAF        Africa                     South Africa    12  31 2022
## 591   KOR          Asia                      South Korea    12  31 2020
## 592   KOR          Asia                      South Korea    12  31 2021
## 593   KOR          Asia                      South Korea    12  31 2022
## 594   SSD        Africa                      South Sudan    12  31 2020
## 595   SSD        Africa                      South Sudan    12  31 2021
## 596   SSD        Africa                      South Sudan    12  31 2022
## 597   ESP        Europe                            Spain    12  31 2020
## 598   ESP        Europe                            Spain    12  31 2021
## 599   ESP        Europe                            Spain    12  31 2022
## 600   LKA          Asia                        Sri Lanka    12  31 2020
## 601   LKA          Asia                        Sri Lanka    12  31 2021
## 602   LKA          Asia                        Sri Lanka    12  31 2022
## 603   SDN        Africa                            Sudan    12  31 2020
## 604   SDN        Africa                            Sudan    12  31 2021
## 605   SDN        Africa                            Sudan    12  31 2022
## 606   SUR South America                         Suriname    12  31 2020
## 607   SUR South America                         Suriname    12  31 2021
## 608   SUR South America                         Suriname    12  31 2022
## 609   SWE        Europe                           Sweden    12  31 2020
## 610   SWE        Europe                           Sweden    12  31 2021
## 611   SWE        Europe                           Sweden    12  31 2022
## 612   CHE        Europe                      Switzerland    12  31 2020
## 613   CHE        Europe                      Switzerland    12  31 2021
## 614   CHE        Europe                      Switzerland    12  31 2022
## 615   SYR          Asia                            Syria    12  31 2020
## 616   SYR          Asia                            Syria    12  31 2021
## 617   SYR          Asia                            Syria    12  31 2022
## 618   TWN          Asia                           Taiwan    12  31 2020
## 619   TWN          Asia                           Taiwan    12  31 2021
## 620   TWN          Asia                           Taiwan    12  31 2022
## 621   TJK          Asia                       Tajikistan    12  31 2020
## 622   TJK          Asia                       Tajikistan    12  31 2021
## 623   TJK          Asia                       Tajikistan    12  31 2022
## 624   TZA        Africa                         Tanzania    12  31 2020
## 625   TZA        Africa                         Tanzania    12  31 2021
## 626   TZA        Africa                         Tanzania    12  31 2022
## 627   THA          Asia                         Thailand    12  31 2020
## 628   THA          Asia                         Thailand    12  31 2021
## 629   THA          Asia                         Thailand    12  31 2022
## 630   TLS          Asia                            Timor    12  31 2020
## 631   TLS          Asia                            Timor    12  31 2021
## 632   TLS          Asia                            Timor    12  31 2022
## 633   TGO        Africa                             Togo    12  31 2020
## 634   TGO        Africa                             Togo    12  31 2021
## 635   TGO        Africa                             Togo    12  31 2022
## 636   TKL       Oceania                          Tokelau    12  31 2020
## 637   TKL       Oceania                          Tokelau    12  31 2021
## 638   TKL       Oceania                          Tokelau    12  31 2022
## 639   TON       Oceania                            Tonga    12  31 2020
## 640   TON       Oceania                            Tonga    12  31 2021
## 641   TON       Oceania                            Tonga    12  31 2022
## 642   TTO North America              Trinidad and Tobago    12  31 2020
## 643   TTO North America              Trinidad and Tobago    12  31 2021
## 644   TTO North America              Trinidad and Tobago    12  31 2022
## 645   TUN        Africa                          Tunisia    12  31 2020
## 646   TUN        Africa                          Tunisia    12  31 2021
## 647   TUN        Africa                          Tunisia    12  31 2022
## 648   TUR          Asia                           Turkey    12  31 2020
## 649   TUR          Asia                           Turkey    12  31 2021
## 650   TUR          Asia                           Turkey    12  31 2022
## 651   TKM          Asia                     Turkmenistan    12  31 2020
## 652   TKM          Asia                     Turkmenistan    12  31 2021
## 653   TKM          Asia                     Turkmenistan    12  31 2022
## 654   TCA North America         Turks and Caicos Islands    12  31 2020
## 655   TCA North America         Turks and Caicos Islands    12  31 2021
## 656   TCA North America         Turks and Caicos Islands    12  31 2022
## 657   TUV       Oceania                           Tuvalu    12  31 2020
## 658   TUV       Oceania                           Tuvalu    12  31 2021
## 659   TUV       Oceania                           Tuvalu    12  31 2022
## 660   UGA        Africa                           Uganda    12  31 2020
## 661   UGA        Africa                           Uganda    12  31 2021
## 662   UGA        Africa                           Uganda    12  31 2022
## 663   UKR        Europe                          Ukraine    12  31 2020
## 664   UKR        Europe                          Ukraine    12  31 2021
## 665   UKR        Europe                          Ukraine    12  31 2022
## 666   ARE          Asia             United Arab Emirates    12  31 2020
## 667   ARE          Asia             United Arab Emirates    12  31 2021
## 668   ARE          Asia             United Arab Emirates    12  31 2022
## 669   GBR        Europe                   United Kingdom    12  31 2020
## 670   GBR        Europe                   United Kingdom    12  31 2021
## 671   GBR        Europe                   United Kingdom    12  31 2022
## 672   USA North America                    United States    12  31 2020
## 673   USA North America                    United States    12  31 2021
## 674   USA North America                    United States    12  31 2022
## 675   VIR North America     United States Virgin Islands    12  31 2020
## 676   VIR North America     United States Virgin Islands    12  31 2021
## 677   VIR North America     United States Virgin Islands    12  31 2022
## 678   URY South America                          Uruguay    12  31 2020
## 679   URY South America                          Uruguay    12  31 2021
## 680   URY South America                          Uruguay    12  31 2022
## 681   UZB          Asia                       Uzbekistan    12  31 2020
## 682   UZB          Asia                       Uzbekistan    12  31 2021
## 683   UZB          Asia                       Uzbekistan    12  31 2022
## 684   VUT       Oceania                          Vanuatu    12  31 2020
## 685   VUT       Oceania                          Vanuatu    12  31 2021
## 686   VUT       Oceania                          Vanuatu    12  31 2022
## 687   VAT        Europe                          Vatican    12  31 2020
## 688   VAT        Europe                          Vatican    12  31 2021
## 689   VAT        Europe                          Vatican    12  31 2022
## 690   VEN South America                        Venezuela    12  31 2020
## 691   VEN South America                        Venezuela    12  31 2021
## 692   VEN South America                        Venezuela    12  31 2022
## 693   VNM          Asia                          Vietnam    12  31 2020
## 694   VNM          Asia                          Vietnam    12  31 2021
## 695   VNM          Asia                          Vietnam    12  31 2022
## 696   WLF       Oceania                Wallis and Futuna    12  31 2020
## 697   WLF       Oceania                Wallis and Futuna    12  31 2021
## 698   WLF       Oceania                Wallis and Futuna    12  31 2022
## 699   YEM          Asia                            Yemen    12  31 2020
## 700   YEM          Asia                            Yemen    12  31 2021
## 701   YEM          Asia                            Yemen    12  31 2022
## 702   ZMB        Africa                           Zambia    12  31 2020
## 703   ZMB        Africa                           Zambia    12  31 2021
## 704   ZMB        Africa                           Zambia    12  31 2022
## 705   ZWE        Africa                         Zimbabwe    12  31 2020
## 706   ZWE        Africa                         Zimbabwe    12  31 2021
## 707   ZWE        Africa                         Zimbabwe    12  31 2022
##     new_cases new_deaths people_fully_vaccinated
## 1           0          0                    <NA>
## 2          20          0                    <NA>
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## 592      4872        108                42345794
## 593     57527         63                44379786
## 594        15          0                    <NA>
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## 597     18984        166                    <NA>
## 598    150534        102                    <NA>
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## 600       597          5                    <NA>
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## 602         5          0                    <NA>
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## 612      4209         92                      12
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## 614       878          3                 6011602
## 615       101          8                    <NA>
## 616        39          4                    <NA>
## 617         0          0                    <NA>
## 618        NA         NA                    <NA>
## 619        NA         NA                16159278
## 620        NA         NA                    <NA>
## 621         3          0                    <NA>
## 622         0          0                    <NA>
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## 630         0          0                    <NA>
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## 633         7          0                    <NA>
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## 644         0          0                    <NA>
## 645      2414         50                    <NA>
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## 650         0          0                    <NA>
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## 665         0          0                    <NA>
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## 671      7140        151                    <NA>
## 672    208904       3351                   46916
## 673    474309       1823               210282783
## 674         0          0               229504378
## 675         6          0                    <NA>
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## 680         0          0                    <NA>
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covid_stats <- covid_date |> 
  group_by(iso3c, continent, country, year) |> 
  summarize(cases = sum(new_cases),
            deaths = sum(new_deaths),
            vaxed = sum(people_fully_vaccinated))

covid_stats <- covid_stats |> 
  mutate(vaxed = as.double(vaxed))

covid_stats
## # A tibble: 707 × 7
## # Groups:   iso3c, continent, country [236]
##    iso3c continent     country      year cases deaths vaxed
##    <chr> <chr>         <chr>       <dbl> <int>  <int> <dbl>
##  1 ABW   North America Aruba        2020    50      0    NA
##  2 ABW   North America Aruba        2021   671      0    NA
##  3 ABW   North America Aruba        2022     0      0    NA
##  4 AFG   Asia          Afghanistan  2020     0      0    NA
##  5 AFG   Asia          Afghanistan  2021    20      0    NA
##  6 AFG   Asia          Afghanistan  2022    43      2    NA
##  7 AGO   Africa        Angola       2020    62      2    NA
##  8 AGO   Africa        Angola       2021     0      0    NA
##  9 AGO   Africa        Angola       2022     0      0    NA
## 10 AIA   North America Anguilla     2020     0      0    NA
## # ℹ 697 more rows
covid_cov <- covid_stats |> 
  mutate(
    disease = 'COVID19',
    disease_desc = 'Coronavirus 19'
    )

covid_clean <- covid_cov |> 
  left_join(wb_population, by = c("iso3c", country = "country_name", "year")) |> 
  mutate(coverage = vaxed/pop_total)
  

covid_clean
## # A tibble: 707 × 11
## # Groups:   iso3c, continent, country [236]
##    iso3c continent     country      year cases deaths vaxed disease disease_desc
##    <chr> <chr>         <chr>       <dbl> <int>  <int> <dbl> <chr>   <chr>       
##  1 ABW   North America Aruba        2020    50      0    NA COVID19 Coronavirus…
##  2 ABW   North America Aruba        2021   671      0    NA COVID19 Coronavirus…
##  3 ABW   North America Aruba        2022     0      0    NA COVID19 Coronavirus…
##  4 AFG   Asia          Afghanistan  2020     0      0    NA COVID19 Coronavirus…
##  5 AFG   Asia          Afghanistan  2021    20      0    NA COVID19 Coronavirus…
##  6 AFG   Asia          Afghanistan  2022    43      2    NA COVID19 Coronavirus…
##  7 AGO   Africa        Angola       2020    62      2    NA COVID19 Coronavirus…
##  8 AGO   Africa        Angola       2021     0      0    NA COVID19 Coronavirus…
##  9 AGO   Africa        Angola       2022     0      0    NA COVID19 Coronavirus…
## 10 AIA   North America Anguilla     2020     0      0    NA COVID19 Coronavirus…
## # ℹ 697 more rows
## # ℹ 2 more variables: pop_total <dbl>, coverage <dbl>
#Create ID and join to data set

covid_key = mutate(covid_clean,
             id = paste(iso3c, year, disease, sep = '_')) 

covid_key <- covid_key |> 
  mutate(antig = "SARSCOV2",
         antig_desc = "SARS Coronavirus 2 vaccine")

covid_key
## # A tibble: 707 × 14
## # Groups:   iso3c, continent, country [236]
##    iso3c continent     country      year cases deaths vaxed disease disease_desc
##    <chr> <chr>         <chr>       <dbl> <int>  <int> <dbl> <chr>   <chr>       
##  1 ABW   North America Aruba        2020    50      0    NA COVID19 Coronavirus…
##  2 ABW   North America Aruba        2021   671      0    NA COVID19 Coronavirus…
##  3 ABW   North America Aruba        2022     0      0    NA COVID19 Coronavirus…
##  4 AFG   Asia          Afghanistan  2020     0      0    NA COVID19 Coronavirus…
##  5 AFG   Asia          Afghanistan  2021    20      0    NA COVID19 Coronavirus…
##  6 AFG   Asia          Afghanistan  2022    43      2    NA COVID19 Coronavirus…
##  7 AGO   Africa        Angola       2020    62      2    NA COVID19 Coronavirus…
##  8 AGO   Africa        Angola       2021     0      0    NA COVID19 Coronavirus…
##  9 AGO   Africa        Angola       2022     0      0    NA COVID19 Coronavirus…
## 10 AIA   North America Anguilla     2020     0      0    NA COVID19 Coronavirus…
## # ℹ 697 more rows
## # ℹ 5 more variables: pop_total <dbl>, coverage <dbl>, id <chr>, antig <chr>,
## #   antig_desc <chr>
covid_key <- covid_key[,c(12,1,2,3,4,5,6,11,8,9,13,14)]

Join COVID table onto VPD data using full join (no existing COVID data to join onto via Left join)

#| echo: false
#| warning: false


#Full join of both data sets using ID field

diseases <- vpd_combo |> 
  full_join(covid_key, by = c("id", "iso3c", "country", "year", "cases","disease", "disease_desc", "coverage", "antig", "antig_desc"))

diseases_update <- diseases |> 
             mutate(vpd = case_when(disease != "COVID19" ~ "VPD",
                                    disease == "COVID19" ~ "COVID"))

#Drop id & group for future joins and analysis

diseases_total <- diseases_update[,-c(1,2,13,14,16,17)]

diseases_total |> 
  view()

#Look at missingness

miss_var_summary(diseases_total)
## # A tibble: 12 × 3
##    variable     n_miss pct_miss
##    <chr>         <int>    <dbl>
##  1 coverage      52604   66.3  
##  2 antig         35599   44.9  
##  3 antig_desc    35599   44.9  
##  4 ir            18547   23.4  
##  5 cases         17831   22.5  
##  6 units           707    0.892
##  7 iso3c             0    0    
##  8 country           0    0    
##  9 year              0    0    
## 10 disease           0    0    
## 11 disease_desc      0    0    
## 12 vpd               0    0
#Reorder columns

diseases_total <- diseases_total |> 
  relocate(vpd, .after = year) |> 
  relocate(antig, .after = disease_desc) |> 
  relocate(antig_desc, .after = antig) |> 
  rename(vax = antig,
         vax_desc = antig_desc) |> 
  view()

Shrink data set down to 1990-2023 for easier manipulations but long enough for meaningful findings

#| echo: false
#| warning: false

#Filter Data from after 1990

diseases_short <- diseases_total |> 
                  filter(year >= 1990 )

diseases_short
## # A tibble: 66,512 × 12
##    iso3c country  year vpd   disease  disease_desc  vax     vax_desc cases units
##    <chr> <chr>   <dbl> <chr> <chr>    <chr>         <chr>   <chr>    <dbl> <chr>
##  1 ABW   Aruba    2021 VPD   RUBELLA  Rubella       RCV1    Rubella…     0 per …
##  2 ABW   Aruba    2021 VPD   POLIO    Poliomyelitis IPV1    Inactiv…     0 per …
##  3 ABW   Aruba    2021 VPD   POLIO    Poliomyelitis IPV1_F… Fractio…     0 per …
##  4 ABW   Aruba    2021 VPD   POLIO    Poliomyelitis IPV2    Inactiv…     0 per …
##  5 ABW   Aruba    2021 VPD   POLIO    Poliomyelitis IPV2_F… Fractio…     0 per …
##  6 ABW   Aruba    2021 VPD   POLIO    Poliomyelitis POL3    Polio, …     0 per …
##  7 ABW   Aruba    2021 VPD   TTETANUS Tetanus       TT2PLUS Tetanus…     0 per …
##  8 ABW   Aruba    2021 VPD   TTETANUS Tetanus       TTCV4   Tetanus…     0 per …
##  9 ABW   Aruba    2021 VPD   TTETANUS Tetanus       TTCV5   Tetanus…     0 per …
## 10 ABW   Aruba    2021 VPD   TTETANUS Tetanus       TTCV6   Tetanus…     0 per …
## # ℹ 66,502 more rows
## # ℹ 2 more variables: ir <dbl>, coverage <dbl>

Step 5: Adding Economic Data

Join onto WB country data

#| echo: false
#| warning: false

#Join to VPD data for full disease comparison data set

diseases_clean <- diseases_short |> 
          left_join(wb_data, by = c("iso3c", "country", "year"))

#Remove unneeded columns

diseases_clean <- diseases_clean[,-c(16)]

diseases_clean |> 
  select(iso3c, country, year) |> 
  filter(is.na(country)) |> 
  unique() |> 
  view()

diseases_clean |> 
  filter(grepl("antilles", country, ignore.case = TRUE))
## # A tibble: 74 × 18
##    iso3c country      year vpd   disease disease_desc vax   vax_desc cases units
##    <chr> <chr>       <dbl> <chr> <chr>   <chr>        <chr> <chr>    <dbl> <chr>
##  1 ANT   Netherland…  2000 VPD   DIPHTH… Diphtheria   <NA>  <NA>        NA per …
##  2 ANT   Netherland…  2000 VPD   MUMPS   Mumps        <NA>  <NA>        NA per …
##  3 ANT   Netherland…  2000 VPD   MEASLES Measles      MCV1  Measles…    NA per …
##  4 ANT   Netherland…  2000 VPD   MEASLES Measles      MCV2  Measles…    NA per …
##  5 ANT   Netherland…  2000 VPD   YFEVER  Yellow fever YFV   Yellow …    NA per …
##  6 ANT   Netherland…  2000 VPD   PERTUS… Pertussis    <NA>  <NA>        NA per …
##  7 ANT   Netherland…  2000 VPD   POLIO   Poliomyelit… POL3  Polio, …     0 per …
##  8 ANT   Netherland…  2000 VPD   CRS     Congenital … <NA>  <NA>        NA per …
##  9 ANT   Netherland…  2000 VPD   RUBELLA Rubella      <NA>  <NA>        NA per …
## 10 ANT   Netherland…  2000 VPD   TTETAN… Tetanus      TT2P… Tetanus…    NA per …
## # ℹ 64 more rows
## # ℹ 8 more variables: ir <dbl>, coverage <dbl>, gdp <dbl>, gdp_ppp <dbl>,
## #   gni <dbl>, region <chr>, income_level <chr>, gdp_health <dbl>
diseases_clean |> 
  filter(grepl("kosovo", country, ignore.case = TRUE))
## # A tibble: 27 × 18
##    iso3c country      year vpd   disease disease_desc vax   vax_desc cases units
##    <chr> <chr>       <dbl> <chr> <chr>   <chr>        <chr> <chr>    <dbl> <chr>
##  1 XKX   Kosovo (in…  2021 VPD   JAPENC  Japanese en… JAPE… Japanes…    NA per …
##  2 XKX   Kosovo (in…  2021 VPD   YFEVER  Yellow fever YFV   Yellow …    NA per …
##  3 XKX   Kosovo (in…  2021 VPD   TTETAN… Tetanus      TT2P… Tetanus…    NA per …
##  4 XKX   Kosovo (in…  2021 VPD   TTETAN… Tetanus      TTCV4 Tetanus…    NA per …
##  5 XKX   Kosovo (in…  2021 VPD   TTETAN… Tetanus      TTCV5 Tetanus…    NA per …
##  6 XKX   Kosovo (in…  2021 VPD   TTETAN… Tetanus      TTCV6 Tetanus…    NA per …
##  7 XKX   Kosovo (in…  2021 VPD   MUMPS   Mumps        <NA>  <NA>        NA per …
##  8 XKX   Kosovo (in…  2021 VPD   PERTUS… Pertussis    PERC… Pertuss…    NA per …
##  9 XKX   Kosovo (in…  2021 VPD   PERTUS… Pertussis    PERC… Pertuss…    NA per …
## 10 XKX   Kosovo (in…  2021 VPD   CRS     Congenital … <NA>  <NA>        NA per …
## # ℹ 17 more rows
## # ℹ 8 more variables: ir <dbl>, coverage <dbl>, gdp <dbl>, gdp_ppp <dbl>,
## #   gni <dbl>, region <chr>, income_level <chr>, gdp_health <dbl>
#clean up names & add flag

diseases_clean <- diseases_clean |> 
  mutate(flag = iso3c_to_x(iso3c, destination = "unicode.symbol"))

diseases_clean |> 
  select(iso3c, country, year) |> 
  filter(iso3c == "ANT" | iso3c == "XKX") |> 
  unique() |> 
  view()

Add IMF Growth Data

#IMF Growth Data Set Import

imf_growth <- read_excel(
  "C:/Users/joeau/OneDrive - Johns Hopkins/SAIS/Year 2/Sustainable Finance/final_project/00_data_raw/ECON/imf_export.xls")

imf_growth <- imf_growth |> 
  slice(2:n()) |>
  pivot_longer(!'Real GDP growth (Annual percent change)', names_to = "year", values_to = "growth_rate") |> 
  mutate(growth_rate = ifelse(growth_rate == "no data", "", growth_rate),
         growth_rate = format(growth_rate, nsmall = 2),
         growth_rate = as.numeric(growth_rate),
         year = as.numeric(year)) |> 
  rename(country = 'Real GDP growth (Annual percent change)') |>
  view()

#Filter down to after 1990

imf_growth <- imf_growth |> 
  filter(year >= 1990)

#Check countries

imf_growth |> 
  distinct(country) |> 
  view()

#Clean names

imf <- imf_growth |> 
  mutate(iso3c = country_name_regex_to_iso3c(country),
         country = iso3c_to_country_name(iso3c)) 
  
imf <- imf[,c(4,1,2,3)]

#Join onto main data set

diseases_final <- diseases_clean |> 
          left_join(imf, by = c("iso3c", "country", "year"))

Step 6: Write file to .csv

Now that data is assembled, write to a .csv file for storage and use later in analysis and exploration

path_out = 'C:\\Users\\joeau\\OneDrive - Johns Hopkins\\SAIS\\Year 2\\Sustainable Finance\\final_project\\03_data_processed\\'
fileName = paste(path_out, 'vpd_covid_project.csv',sep = '')
write.csv(diseases_final,fileName)

Errors and areas for help

Vaccine pricing & expenditure data

For part of this analysis, would like to analyze VPD vaccination as part of health expenditure to try to illustrate an effect of COVID-19 on VPD immunization coverage. Data seems hard to find and might be better to wait for data exploration of particular pathogens to narrow down data to download?

Ideas:

  • UNICEF

    • By specific antigen

    • Over year period

    • Not market price, contracted price

How to select vaccine price data?

Further, for vaccine prices does it make sense to show prices over time if they have been negotiated through multi-laterals like UNICEF? These are likely subsidized costs compared to market price. Better to narrow down to most burdensome VPDs and then show prices so data is available?

Interested in presenting something similar to this:

Vaccine Affordability - UNDP Data Futures Platform

Vaccination coverage data quality issues

Another issue identified is a mismatch in vaccination coverage (2 parts)

  1. Vaccination data - lists additional vaccines for pathogens not in case data set. Current plan is to only analyze pathogens in case data set and exclude others in vaccination coverage.

  2. There are some combination vaccines that are skewing data - DPT is a Diptheria/Pertussis combination vaccine and join is only occurring on Diptheria. Is there a known work around or way to approximate match so it double counts only in this instance for both pathogens?

Data cleaning/standardization of units

Another two issues are standardization of units

  • Incident rates are measures as either per 1,000,000 <15 population, per 1,000 live births, or per 1,000,000 total population

  • Vaccination coverage is measured both at the administrative and official levels

  • Econ data in total $USD (maybe present in $M USD?)

Data to illustrate value/impact for investors

Finally, the message I am trying to end this project with is not only the disruption of COVID-19 and the burden of VPDs/Vaccine coverages, but to also show the value of investing and funding these vaccines for impact investors:

  • Need to somehow show value for money

  • Potential for growth

  • Returns on human live and capital investment (R&D might be hard to show)