314-456-5538 | Cielly.morena.fm@gmail.com | TWitter: @franmorena98 | Google Scholar: Francielly Morena
Experienced Student Researcher in physiology, exercise, and cancer. Earned BS in Exercise Science and desiring to further develop more skills to perform in the scientific research field and as a college professor. Passionate about learning and mentoring. Currently working on my Doctorate degree at University of Arkansas.
PhD in Health, Sports, and Exercise Science |
University of Arkansas
JULY 2020 – CURRENT. GPA: 3.909
BS in Exercise Science | Missouri Baptist
University
AUGUST 2018 – MARCH 2020
Transferred student from University of Sao Paulo, Brazil. GPA: 3.7
BS in Exercise Science | University of Sao Paulo,
Sao Paulo, Brazil
JANUARY 2016 – JULY 2018
Research Assistant | University of Arkansas,
Fayetteville, Arkansas
JULY 2022 – CURRENT
Responsible for leading and collecting data of two projects funded by an
R01 NIH grant. Currently working with maintenance of Bnip3 genetic
deletion and Opa1 transgenic overexpression to mitigate cancer-induced
muscle atrophy. Besides that, my responsibility expands to writing
manuscripts, grants, and coordinate and mentor multiple undergraduate
students.
Graduate Student Organization Representative
JULY 2022 – CURRENT
Responsible for representing the graduate student body (599 students) in
Graduate-Professional Student Congress, with voting privileges. I am
founder and responsible for the Minority Group and Women in Science
(MGWS) Support group and coordinate recognition awards by faculty
appointment. The MGWS is a support group to empower minorities and women
in science and recognize outstanding efforts and contribution to
science.
Graduate Assistant | University of Arkansas,
Fayetteville, Arkansas
JULY 2020 – JULY 2022
Responsible for undergraduate level lecture planning, make slides,
grading, teach technical procedures, assist student in and out on
classroom setting. Research duties in focusing on cancer cachexia and
mitochondrial health.
Collaboration in Research | Missouri Baptist
University, St. Louis, Missouri
AUGUST 2019 – MAY 2020
Helping in data collection of a Sport Phycology research. The purpose of
this research is seeing the effects of Self-Control training in physical
performance.
Teaching Assistant | Missouri Baptist University,
St. Louis, Missouri
AUGUST 2019 – MAY 2020
Student teaching assistant for undergraduate Testing and Prescription
laboratory. Responsible for Lecture planning, make slides, grading,
teach technical procedures, assist student in and out on classroom
setting.
Student Researcher | University of Sao Paulo, Sao
Paulo, Brazil
OCTOBER 2016 – JULY 2018
Worked on my own research project and helped others during experiments.
Project: Characterization of The Effects of Physical Exercise In The
Structural Alteration of Tumor In Murine Cancer Models. With
participation in the SIICUSP, Symposium of scientific initiation of
University of Sao Paulo.
Lim S, Lee D, Morena Da Silva F, Koopmans P, Vechetti IJ Jr, von Walden F, Greene NP, Murach KA. MicroRNA Control of the Myogenic Cell Transcriptome and Proteome: The Role of miR-16. Am J Physiol Cell Physiol. 2023 Mar 27. doi: 10.1152/ajpcell.00071.2023. Epub ahead of print. PMID: 36971422. PI. Nicholas Greene and Kevin Murach. Role: Middle Author
Morena da Silva, F., Lim, S., Cabrera, A.R.,
Schrems, E.R., Jones III, R.G., Rosa-Caldwell, M., Washington, T.A.,
Murach, K.A. and Greene, N.P., 2022. The Time-Course of Cancer
Cachexia Onset Reveals Biphasic Transcriptional Disruptions in Female
Skeletal Muscle Distinct from Males. bioRxiv, pp.2022-11.
PI: Nicholas Greene, Role: First Author
Murach, K.A., Liu, Z., Jude, B., Figueiredo, V.C., Wen, Y.,
Khadgi, S., Lim, S., da Silva, F.M., Greene, N.P.,
Lanner, J.T. and McCarthy, J.J., 2022. Multi-transcriptome analysis
following an acute skeletal muscle growth stimulus yields tools for
discerning global and MYC regulatory networks. Journal of
Biological Chemistry, 298(11).
PI & First Author: Kevin A. Murach, Role: Middle Author.
Jones III, R.G., Dimet‐Wiley, A., Haghani, A., da Silva, F.M., Brightwell, C.R., Lim, S., Khadgi, S., Wen, Y., Dungan, C.M., Brooke, R.T. and Greene, N.P., 2023. A molecular signature defining exercise adaptation with ageing and in vivo partial reprogramming in skeletal muscle. The Journal of Physiology, 601(4), pp.763-782. PI: Kevin A. Murach. First Author: Ronal G. Jones III, Role: Middle Author
Lim, S., Deaver, J.W., Rosa-Caldwell, M.E., Haynie, W.S.,
Morena da Silva, F., Cabrera, A.R., Schrems, E.R.,
Saling, L.W., Jansen, L.T., Dunlap, K.R. and Wiggs, M.P., Washington,
T.A. and Greene, N.P. 2022. Development of metabolic and contractile
alterations in development of cancer cachexia in female tumor-bearing
mice. Journal of Applied Physiology, 132(1), pp.58-72.
PI: Nicholas Greene, First Author: Seongkyun Lim, Role: Middle
Author.
Seongkyun Lim, J. William Deaver, Megan E. Rosa-Caldwell, David
E. Lee, Francielly Morena da Silva, Ana Regina Cabrera,
Eleanor R. Schrems, Landen W. Saling, Tyrone A. Washington, James D.
Fluckey, and Nicholas P. Greene. Muscle miR-16 deletion results in
impaired insulin sensitivity and contractile function in a sex-dependent
manner. American Journal of Physiology-Endocrinology and Metabolism
2022 322:3, E278-E292
PI: Nicholas Greene, First Author: Seongkyun Lim, Role: Middle
Author.
Morena da Silva, F., Rosa-Caldwell, M.E.,
Schrems, E.R., Martinez, L., Amos, M.G., Lim, S., Cabrera, A.R., Brown,
J.L., Washington, T.A. and Greene, N.P., 2022. PGC-1α overexpression
is not sufficient to mitigate cancer cachexia in either male or female
mice. Applied Physiology, Nutrition, and Metabolism, 47(9),
pp.933-948.
PI: Nicholas Greene, Role: First Author.
Rosa‐Caldwell, M.E., Lim, S., Haynie, W.A., Brown, J.L., Deaver,
J.W., Morena Da Silva, F., Jansen, L.T., Lee, D.E.,
Wiggs, M.P., Washington, T.A. and Greene, N.P., 2021. Female mice
may have exacerbated catabolic signalling response compared to male mice
during development and progression of disuse atrophy. Journal of
Cachexia, Sarcopenia and Muscle, 12(3), pp.717-730.
PI: Nicholas Greene, First Author: Megan Rosa-Caldwell, Role: Middle
Author.
In preparation
Active Title: Development of Targeted Approaches in Prevention of Cancer-cachexia PI: Nicholas P. Greene Agency: NIH NIAMS Type: R01 AREA Award, $1.600,000.00 (R01AR075794-01A1) Period: July 1, 2020 – June 30, 2025 Role: Graduate Research Assistant
Past Title: Mitochondrial Degeneration – The Root of Skeletal Muscle Atrophy PI: Nicholas P. Greene Agency: NIH NIAMS Type: R15 AREA Award, $412,668.00 (R15AR069913) Period: July 1, 2017 – June 30, 2021 Role: Graduate Research Assistant
Applied, not awarded: Central ACSM PD Student Research Grant Title: Effects of Circadian Rhythm Genes on Cancer Cachexia Role: PI
Applied, revision pending: NCI F99/K00 Pre-doctoral to post-doctoral transitional grant Title: Mitophagy, the Circadian Rhythm, and Cancer Cachexia Role: PI
GPSC STEM Research Grant, review pending: Title: Circadian rhythm manipulation effects on cancer cachexia Role: PI
Oustanding PhD Student Nominee | Univeristy of
Arkansas 2023
Outstanding PhD Student of the Health Human Performande and Recreation
Department
APS Award | American Physiological Society
2021 Outstanding Flash Talk Presentation
KON honor member | Missouri Baptist University
2019
Outstanding Student on Health and Sports Science Department
CNPq Research Scholarship| University of Sao
Paulo
2017 – 2018
Undergraduate researcher scholarship
National ACSM Meeting – 5 minutes talk 2022, San Diego, California, USA. A Biological Sex Comparison of Muscle Contractile Function and Calcium regulation in The Onset of Colorectal Cancer-Induced Cachexia Francielly Morena da Silva, J. William Deaver, Seongkyun Lim, Ana Regina Cabrera, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Nicholas P. Greene
International Biochemistry of Exercise Conference (IBEC) 2022, Toronto, Canada. A Transcriptional Signature of Cancer Cachexia Development in Female Mice Francielly Morena da Silva, Ana Regina Cabrera, Seongkyun Lim, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
Sarcopenic Obesity Alters Global Gene Expression in the Gastrocnemius Muscle Eleanor R. Schrems, Francielly Morena da Silva, Landen W. Saling, Seongkyun Lim, Ana Regina Cabrera, Kevin A. Murach, Nicholas P. Greene, Tyrone A. Washington
A Transcriptomic Comparison of Biological Sex and Stimulus in Muscle Atrophy: Focus on Satellite-Cell Markers Seongkyun Lim, Francielly Morena da Silva, Ana Regina Cabrera, Megan E. Rosa-Caldwell, Jacob L. Brown, J. William Deaver, Tyrone A. Washington, Kevin A. Murach, and Nicholas P. Greene
Sarcopenia, Cachexia and Wasting Disorders Meeting (SCWD) 2022, Lisbon, Portugal. Colorectal Cancer-Induced Cachexia Reduces Dnmt3a and Differentially Alters the Skeletal Muscle Transcriptome by Biological Sex Ana Regina Cabrera, Francielly Morena da Silva, Seongkyun Lim, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
OPA1 overexpression may protect against cancer-induced muscle wasting Tsitkanou S, Lim S, Morena da Silva F, Cabrera AR, Schrems ER, Washington TA, Murach KA, Greene NP
ABI Fall Research Symposium 2022, Fayetteville, Arkansas, USA. Colorectal Cancer-Induced Cachexia Reduces Dnmt3a and Differentially Alters the Skeletal Muscle Transcriptome by Biological Sex Ana Regina Cabrera, Francielly Morena da Silva, Seongkyun Lim, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
AIMRC Symposium 2022, Fayetteville, Arkansas, USA. Colorectal Cancer-Induced Cachexia Reduces Dnmt3a and Differentially Alters the Skeletal Muscle Transcriptome by Biological Sex Ana Regina Cabrera, Francielly Morena da Silva, Seongkyun Lim, Tyrone A. Washington, Kevin A. Murach, Nicholas P. Greene
ACSM 2022, San Diego, California, USA. A Biological Sex Comparison of Muscle Contractile Function and Calcium regulation in The Onset of Colorectal Cancer-Induced Cachexia Francielly Morena da Silva, J. William Deaver, Seongkyun Lim, Ana Regina Cabrera, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Nicholas P. Greene
Differential Induction of Regulators of Protein Turnover during C26-induced Cancer Cachexia between Biological Sex Seongkyun Lim, J. William Deaver, Francielly Morena da Silva, Ana Regina Cabrera, Eleanor R. Schrems, Landen W. Saling, Anthony Campitelli, Tyrone A. Washington, Nicholas P. Greene, FACSM.
Mitochondrial Quality Control Markers During the Onset of Colorectal Cancer-Induced Cachexia: A Biological Sex Comparison Ana Regina Cabrera, J. William Deaver, Seongkyun Lim, Francielly Morena da Silva, Eleanor Schrems, Landen Saling, Anthony Campitelli, Tyrone A. Washington, Nicholas P. Greene
Analysis of the Transcriptome of Soleus Muscle in Sarcopenic Obese Mice Eleanor R. Schrems, Landen W. Saling, Breanna M. Williams, Francielly Morena Da Silva, Regina Cabrera, Seongkyun Lim, Nicholas P. Greene, FACSM, Tyrone A. Washington
Growth Differentiation Factor 5 Is A Paracrine Regulator in Sarcopenic Obesity Landen W. Saling, Eleanor R. Schrems, Seongkyun Lim, Francielly Morena Da Silva, Regina Cabrera1, Kevin A. Murach, Nicholas P. Greene, FACSM, Tyrone A. Washington
Males, but Not Females, Demonstrate Mitochondrial Dysfunction in the C26 Model of Cancer Cachexia Ricky D. Solis, J. William Deaver, Eleanor R. Schrems, Ana Regina Cabrera, Seongkyun Lim, Francielly Morena Da Silva, Tyrone A. Washington, Nicholas P. Greene, and Michael P. Wiggs
APS – Flash talk Virtual Presentation 2021 Comparison of the Phenotypic Development of C26 Colorectal Cancer-Induced Cachexia Between Biological Sexes Francielly Morena da Silva, J. William Deaver, Seongkyun Lim, Ana Regina Cabrera, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Nicholas P. Greene
UARK-UAMS Meeting – Poster presentation 2021, Fayetteville, Arkansas, USA. Comparison of the Phenotypic Development of C26 Colorectal Cancer-Induced Cachexia Between Biological Sexes Francielly Morena da Silva, J. William Deaver, Seongkyun Lim, Ana Regina Cabrera, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Nicholas P. Greene
AIMSRC – Poster’s Coauthor 2021, Fayetteville, Arkansas, USA. A Biological Sex Comparison of Muscle Contractile Function in The Onset of Colorectal Cancer-Induced Cachexia Ana Regina Cabrera, J. William Deaver, Seongkyun Lim, Francielly Morena da Silva, Eleanor Schrems, Landen Saling, Tyrone A. Washington, Nicholas P. Greene
Poster Presentation |13th International Sarcopenia, Cachexia and Wasting Disorders Conference Virtual 2020 Francielly Morena da Silva, Seongkyun Lim, Megan E. Rosa-Caldwell1, Wesley S. Haynie, Lisa T. Jansen, Kristen R. Dunlap, J. William Deaver, Michael Wiggs, Tyrone A. Washington, Nicholas P. Greene. Alterations in Extracellular Matrix Remodeling During Early Stages of Cancer Cachexia in Tumor-bearing Female Mice.
Poster Presentation | 13th International Sarcopenia, Cachexia and Wasting Disorders Conference Virtual 2020 Seongkyun Lim, Megan E. Rosa-Caldwell, Wesley S. Haynie, Lisa T. Jansen, Kirsten R. Dunlap, Francielly Morena da Silva, J. William Deaver1, Michael Wiggs, Tyrone A. Washington, Nicholas P. Greene1. Alterations in Mitochondrial Turnover during the Development of Cancer Cachexia in Tumor-Bearing Female Mice.
Poster Presentation | 13th International Sarcopenia, Cachexia and Wasting Disorders Conference Virtual 2020 J. William Deaver, Megan E. Rosa-Caldwell, Wesley A. Haynie, Seongkyun Lim, Jacob L. Brown, **Francielly Morena Da Silva*, Kirsten R. Dunlap1, Lisa T. Jansen, David E. Lee, Michael P. Wiggs, Tyrone A. Washington, Nicholas P. Greene. Early Differential Responses by Sex to Hindlimb-Unloading Induced Muscle Atrophy.
Poster Presentation | SIICUSP University of Sao Paulo, Sao Paulo, Brazil 2018 Francielly Morena da Silva, Joao Gomes, Edilamar Menezes de Oliveira. Characterization of The Effects of Physical Exercise in the Structural Alteration of Tumor in Murine Cancer Models.