90 days survival

death only multivariate

coxph(Surv(death_in_90days_time,death_in_90days_status) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site, data = master)%>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.38 0.20, 0.72 0.003
age_admission 1.01 0.98, 1.04 0.7
sex
    1 — —
    2 1.40 0.78, 2.51 0.3
White
    0 — —
    1 2.45 0.94, 6.39 0.067
hispanic_race
    0 — —
    1 1.01 0.33, 3.09 >0.9
etiology_cirrhosis
    Alcohol — —
    HCV 0.98 0.20, 4.70 >0.9
    Multifactorial 2.22 0.79, 6.25 0.13
    NASH 1.83 0.81, 4.12 0.15
    Other 3.00 1.28, 7.07 0.012
CLIF_C_Score 1.06 1.03, 1.10 <0.001
site
    baylor — —
    indiana 3.91 0.47, 32.4 0.2
    jacksonville 0.60 0.06, 6.08 0.7
    kentukey 1.29 0.11, 15.8 0.8
    MCW 6.93 0.80, 60.1 0.079
    mgh 2.21 0.25, 19.1 0.5
    michigan 3.84 0.42, 35.3 0.2
    oschner 3.71 0.32, 43.2 0.3
    rochester 1.65 0.20, 13.6 0.6
    usc 1.67 0.18, 15.5 0.7
    yale 8.34 0.82, 84.4 0.072
1 HR = Hazard Ratio, CI = Confidence Interval

death or transplant multivariate

coxph(Surv(time_90days,status_90days!=0) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site, data = master)%>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.38 0.27, 0.54 <0.001
age_admission 0.98 0.97, 1.00 0.020
sex
    1 — —
    2 1.04 0.75, 1.43 0.8
White
    0 — —
    1 1.01 0.64, 1.60 >0.9
hispanic_race
    0 — —
    1 0.89 0.53, 1.49 0.7
etiology_cirrhosis
    Alcohol — —
    HCV 0.58 0.25, 1.33 0.2
    Multifactorial 1.56 0.88, 2.79 0.13
    NASH 1.55 0.98, 2.45 0.059
    Other 1.57 0.97, 2.53 0.064
CLIF_C_Score 1.04 1.02, 1.06 <0.001
site
    baylor — —
    indiana 3.20 1.08, 9.42 0.035
    jacksonville 6.14 2.08, 18.1 0.001
    kentukey 2.62 0.77, 8.91 0.12
    MCW 2.16 0.68, 6.86 0.2
    mgh 1.67 0.55, 5.05 0.4
    michigan 1.90 0.56, 6.40 0.3
    oschner 1.21 0.26, 5.53 0.8
    rochester 2.10 0.72, 6.10 0.2
    usc 8.14 2.71, 24.5 <0.001
    yale 3.20 0.85, 12.1 0.086
1 HR = Hazard Ratio, CI = Confidence Interval

Fine and Gray event: death competing risk: liver transplant multivariate

tidycmprsk::crr(Surv(time_90days,status_90days) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site,failcode=1,cencode=0, data = test) %>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.44 0.23, 0.83 0.012
age_admission 1.01 0.97, 1.05 0.6
sex
    1 — —
    2 1.21 0.66, 2.21 0.5
White
    0 — —
    1 2.45 0.85, 7.02 0.10
hispanic_race
    0 — —
    1 1.05 0.31, 3.59 >0.9
etiology_cirrhosis
    Alcohol — —
    HCV 0.93 0.20, 4.28 >0.9
    Multifactorial 1.75 0.63, 4.80 0.3
    NASH 1.64 0.71, 3.81 0.3
    Other 2.88 1.24, 6.68 0.014
CLIF_C_Score 1.07 1.03, 1.11 <0.001
site
    baylor — —
    indiana 2.70 0.28, 25.6 0.4
    jacksonville 0.57 0.05, 6.84 0.7
    kentukey 1.09 0.08, 15.9 >0.9
    MCW 6.23 0.59, 66.3 0.13
    mgh 2.05 0.21, 20.2 0.5
    michigan 3.77 0.38, 37.8 0.3
    oschner 3.38 0.24, 47.4 0.4
    rochester 1.60 0.19, 13.8 0.7
    usc 1.53 0.14, 16.3 0.7
    yale 8.17 0.74, 89.7 0.086
1 HR = Hazard Ratio, CI = Confidence Interval

Fine and Gray event: liver transplant competing risk: death

tidycmprsk::crr(Surv(time_90days,status_90days) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site,failcode=2,cencode=0, data = test) %>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.49 0.31, 0.75 0.001
age_admission 0.99 0.98, 1.01 0.4
sex
    1 — —
    2 0.87 0.59, 1.29 0.5
White
    0 — —
    1 0.70 0.42, 1.16 0.2
hispanic_race
    0 — —
    1 1.02 0.65, 1.61 >0.9
etiology_cirrhosis
    Alcohol — —
    HCV 0.43 0.18, 1.04 0.061
    Multifactorial 1.27 0.68, 2.40 0.5
    NASH 1.07 0.64, 1.79 0.8
    Other 0.87 0.49, 1.55 0.6
CLIF_C_Score 1.01 0.98, 1.03 0.6
site
    baylor — —
    indiana 2.69 0.79, 9.16 0.11
    jacksonville 7.20 2.13, 24.3 0.002
    kentukey 3.31 0.83, 13.3 0.091
    MCW 1.14 0.29, 4.51 0.9
    mgh 1.49 0.42, 5.31 0.5
    michigan 1.33 0.29, 5.99 0.7
    oschner 0.49 0.05, 4.46 0.5
    rochester 1.96 0.58, 6.64 0.3
    usc 6.47 1.85, 22.6 0.003
    yale 1.30 0.23, 7.53 0.8
1 HR = Hazard Ratio, CI = Confidence Interval

death only vasoconstrictor multivariate

coxph(Surv(death_in_90days_time,death_in_90days_status) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site, data = test_vaso)%>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.31 0.14, 0.67 0.003
age_admission 1.00 0.97, 1.04 >0.9
sex
    1 — —
    2 1.48 0.73, 2.98 0.3
White
    0 — —
    1 3.54 1.06, 11.8 0.040
hispanic_race
    0 — —
    1 1.19 0.35, 4.10 0.8
etiology_cirrhosis
    Alcohol — —
    HCV 1.44 0.23, 8.91 0.7
    Multifactorial 5.07 1.45, 17.8 0.011
    NASH 4.09 1.32, 12.7 0.015
    Other 4.44 1.36, 14.5 0.013
CLIF_C_Score 1.09 1.03, 1.14 <0.001
site
    baylor — —
    indiana 1.00 0.11, 8.85 >0.9
    jacksonville 0.08 0.01, 1.11 0.060
    kentukey 0.32 0.02, 4.68 0.4
    MCW 2.84 0.31, 26.1 0.4
    mgh 0.60 0.07, 5.47 0.7
    michigan 0.80 0.05, 13.2 0.9
    oschner 1.31 0.11, 16.1 0.8
    rochester 0.51 0.05, 4.76 0.6
    usc 0.38 0.03, 4.25 0.4
    yale 2.72 0.24, 30.7 0.4
1 HR = Hazard Ratio, CI = Confidence Interval

death or transplant vasoconstrictor multivariate

coxph(Surv(time_90days,status_90days!=0) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site, data = test_vaso)%>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.26 0.16, 0.41 <0.001
age_admission 0.99 0.97, 1.01 0.2
sex
    1 — —
    2 0.87 0.58, 1.32 0.5
White
    0 — —
    1 1.03 0.59, 1.79 >0.9
hispanic_race
    0 — —
    1 0.82 0.44, 1.52 0.5
etiology_cirrhosis
    Alcohol — —
    HCV 0.63 0.25, 1.58 0.3
    Multifactorial 1.68 0.80, 3.51 0.2
    NASH 1.70 0.94, 3.06 0.078
    Other 1.98 1.08, 3.62 0.027
CLIF_C_Score 1.04 1.01, 1.07 0.009
site
    baylor — —
    indiana 1.66 0.36, 7.69 0.5
    jacksonville 3.85 0.83, 17.8 0.084
    kentukey 1.93 0.35, 10.6 0.4
    MCW 1.20 0.25, 5.79 0.8
    mgh 1.71 0.37, 7.85 0.5
    michigan 1.26 0.20, 7.76 0.8
    oschner 0.62 0.08, 4.66 0.6
    rochester 1.18 0.26, 5.45 0.8
    usc 5.53 1.19, 25.7 0.029
    yale 1.85 0.31, 11.2 0.5
1 HR = Hazard Ratio, CI = Confidence Interval

Fine and Gray event: death competing risk: liver transplant vasoconstrictor multivariate

tidycmprsk::crr(Surv(time_90days,status_90days) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+site,failcode=1,cencode=0, data = test_vaso) %>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.30 0.14, 0.62 0.001
age_admission 1.03 0.98, 1.07 0.3
sex
    1 — —
    2 1.05 0.53, 2.08 0.9
White
    0 — —
    1 1.70 0.51, 5.63 0.4
hispanic_race
    0 — —
    1 0.75 0.19, 2.90 0.7
etiology_cirrhosis
    Alcohol — —
    HCV 1.14 0.25, 5.34 0.9
    Multifactorial 1.55 0.56, 4.30 0.4
    NASH 1.39 0.54, 3.53 0.5
    Other 2.65 0.92, 7.61 0.070
site
    baylor — —
    indiana 1.23 0.15, 9.95 0.9
    jacksonville 0.23 0.01, 3.56 0.3
    kentukey 1.08 0.10, 11.9 >0.9
    MCW 2.86 0.35, 23.4 0.3
    mgh 1.15 0.14, 9.66 0.9
    michigan 0.68 0.04, 11.9 0.8
    oschner 1.12 0.09, 13.4 >0.9
    rochester 0.96 0.11, 8.56 >0.9
    usc 0.53 0.04, 6.53 0.6
    yale 2.44 0.31, 19.2 0.4
1 HR = Hazard Ratio, CI = Confidence Interval

Fine and Gray event: liver transplant competing risk: death vasoconstrictor multivariate

tidycmprsk::crr(Surv(time_90days,status_90days) ~ repsonse_cat+age_admission+sex+White+hispanic_race+etiology_cirrhosis+CLIF_C_Score+site,failcode=2,cencode=0, data = test_vaso) %>% tbl_regression(exp = TRUE)
Characteristic HR1 95% CI1 p-value
repsonse_cat
    no response — —
    overall response 0.37 0.20, 0.70 0.002
age_admission 1.00 0.98, 1.03 0.8
sex
    1 — —
    2 0.70 0.41, 1.21 0.2
White
    0 — —
    1 0.69 0.40, 1.18 0.2
hispanic_race
    0 — —
    1 0.90 0.48, 1.69 0.8
etiology_cirrhosis
    Alcohol — —
    HCV 0.41 0.17, 0.99 0.047
    Multifactorial 1.03 0.41, 2.59 >0.9
    NASH 0.94 0.50, 1.73 0.8
    Other 0.85 0.44, 1.64 0.6
CLIF_C_Score 0.99 0.95, 1.02 0.5
site
    baylor — —
    indiana 2.03 0.18, 22.7 0.6
    jacksonville 7.13 0.64, 79.1 0.11
    kentukey 2.53 0.19, 34.2 0.5
    MCW 0.95 0.08, 11.1 >0.9
    mgh 2.40 0.21, 27.1 0.5
    michigan 1.72 0.11, 25.9 0.7
    oschner 0.00 0.00, 0.00 <0.001
    rochester 1.77 0.16, 20.0 0.6
    usc 6.12 0.54, 69.6 0.14
    yale 1.36 0.07, 25.9 0.8
1 HR = Hazard Ratio, CI = Confidence Interval