** THIS IS FOR THE HUNG DATA **

## 
## postnatal  prenatal 
##        20        89

summary of data

#summary of all cases by timescale
tbl_summary(df[,c(2,6:22)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 371 early, N = 471 F, N = 251 p-value2
Deformation.of.Pit.gland 2 (5.6%) 0 (0%) 0 (0%) 0.3
Unknown 1 0 20
TVFB 1 (2.7%) 0 (0%) 0 (0%) 0.5
Unknown 0 0 21
Bowing.of.LT 2 (5.4%) 2 (4.3%) 0 (0%) >0.9
Unknown 0 0 22
Aqueductal.Stenosis 1 (3.0%) 2 (5.3%) 0 (NA%) >0.9
Unknown 4 9 25
Ratio.of.2.planes.AP 46 (42, 50) 40 (36, 44) 17 (16, 19) <0.001
Unknown 1 1 20
Ratio.of.2.planes.within.Lat.ventricle.SI 12.9 (9.3, 15.3) 10.9 (8.8, 13.2) 3.8 (3.6, 4.5) <0.001
Unknown 1 1 20
Thickness.of.CC 1.60 (1.30, 1.80) 1.80 (1.50, 2.00) 1.20 (1.10, 1.40) 0.004
Unknown 0 3 20
Chiari 3.0 (0.0, 8.4) 3.1 (0.0, 10.2) 7.7 (6.6, 10.7) 0.013
Unknown 0 0 2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 18.6 (15.6, 20.9) 17.0 (15.4, 18.4) 6.5 (5.5, 7.3) <0.001
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 45 (41, 54) 38 (33, 46) 22 (18, 23) <0.001
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.00 (3.00, 5.40) 1.90 (1.35, 2.25) 0.00 (0.00, 0.00) <0.001
cortical.thickness 18.6 (15.6, 20.9) 17.0 (15.4, 18.4) 6.5 (5.5, 7.3) <0.001
elongation.of.CP.Glomus 2.70 (2.20, 3.10) 2.60 (2.00, 3.10) 2.80 (2.10, 3.50) 0.6
Unknown 0 2 16
Elongation.of.CP.body 1.60 (1.30, 1.70) 1.30 (1.10, 1.50) 1.90 (1.43, 2.35) 0.008
Unknown 0 2 17
Transependymal.Flow 0 (0%) 0 (0%) 0 (0%)
Unknown 0 0 1
Width.of.L.Atrium 20 (18, 30) 19 (16, 26) 11 (8, 14) <0.001
Unknown 0 0 1
Width.of.R.atrium 17 (15, 26) 16 (15, 23) 11 (7, 13) <0.001
Unknown 0 0 1
1 n (%); Median (IQR)
2 Fisher's exact test; Kruskal-Wallis rank sum test 
#summary of all cases with NA removed by timescale  
tbl_summary(df2[,c(2,6:22)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 321 early, N = 341 p-value2
Deformation.of.Pit.gland 2 (6.2%) 0 (0%) 0.2
TVFB 1 (3.1%) 0 (0%) 0.5
Bowing.of.LT 1 (3.1%) 2 (5.9%) >0.9
Aqueductal.Stenosis 1 (3.1%) 2 (5.9%) >0.9
Ratio.of.2.planes.AP 46 (42, 49) 40 (36, 44) 0.002
Ratio.of.2.planes.within.Lat.ventricle.SI 12.8 (9.3, 15.0) 10.9 (8.8, 12.8) 0.13
Thickness.of.CC 1.55 (1.30, 1.80) 1.70 (1.40, 1.90) 0.2
Chiari 2 (0, 8) 3 (0, 13) 0.2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 19.15 (16.88, 21.00) 17.05 (15.43, 18.25) 0.007
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 45 (39, 53) 39 (33, 46) 0.020
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.15 (3.30, 5.55) 1.90 (1.30, 2.18) <0.001
cortical.thickness 19.15 (16.88, 21.00) 17.05 (15.43, 18.25) 0.007
elongation.of.CP.Glomus 2.70 (2.28, 3.12) 2.55 (2.00, 3.10) 0.2
Elongation.of.CP.body 1.55 (1.30, 1.63) 1.30 (1.10, 1.48) 0.003
Transependymal.Flow 0 (0%) 0 (0%)
Width.of.L.Atrium 20 (16, 25) 22 (16, 26) 0.6
Width.of.R.atrium 16 (15, 19) 18 (15, 24) 0.4
1 n (%); Median (IQR)
2 Fisher's exact test; Wilcoxon rank sum test 
#summary of all cases by pre/postnatal
tbl_summary(df[,c(6:23)],label = `prepost` ~ "Neuroradiologic Findings",by="prepost")%>%
  bold_labels()  %>%add_p()
Characteristic postnatal, N = 201 prenatal, N = 891 p-value2
Deformation.of.Pit.gland 1 (5.0%) 1 (1.5%) 0.4
Unknown 0 21
TVFB 0 (0%) 1 (1.5%) >0.9
Unknown 0 21
Bowing.of.LT 1 (5.0%) 3 (4.5%) >0.9
Unknown 0 22
Aqueductal.Stenosis 0 (0%) 3 (5.7%) 0.6
Unknown 2 36
Ratio.of.2.planes.AP 44 (39, 48) 41 (36, 46) 0.3
Unknown 1 21
Ratio.of.2.planes.within.Lat.ventricle.SI 13.4 (12.1, 14.8) 9.9 (8.0, 13.2) 0.019
Unknown 1 21
Thickness.of.CC 1.70 (1.50, 1.80) 1.60 (1.30, 1.90) 0.6
Unknown 1 22
Chiari 7.9 (3.9, 14.1) 3.5 (0.0, 8.9) 0.013
Unknown 0 2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 16.6 (15.6, 17.5) 15.9 (9.0, 19.1) 0.6
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 42 (38, 54) 36 (27, 46) 0.004
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 2.45 (1.65, 4.00) 1.80 (0.00, 3.40) 0.027
cortical.thickness 16.6 (15.6, 17.5) 15.9 (9.0, 19.1) 0.6
elongation.of.CP.Glomus 2.65 (1.98, 3.03) 2.60 (2.15, 3.30) 0.3
Unknown 0 18
Elongation.of.CP.body 1.35 (1.30, 1.63) 1.40 (1.20, 1.68) >0.9
Unknown 0 19
Transependymal.Flow 0 (0%) 0 (0%)
Unknown 0 1
Width.of.L.Atrium 23 (17, 27) 17 (12, 23) 0.016
Unknown 0 1
Width.of.R.atrium 19 (16, 23) 15 (11, 18) 0.005
Unknown 0 1
1 n (%); Median (IQR)
2 Fisher's exact test; Wilcoxon rank sum test 
#summary of all prenatal cases by timescale    
tbl_summary(df_pre[,c(2,6:22)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 291 early, N = 351 F, N = 251 p-value2
Deformation.of.Pit.gland 1 (3.6%) 0 (0%) 0 (0%) 0.5
Unknown 1 0 20
TVFB 1 (3.4%) 0 (0%) 0 (0%) 0.5
Unknown 0 0 21
Bowing.of.LT 1 (3.4%) 2 (5.7%) 0 (0%) >0.9
Unknown 0 0 22
Aqueductal.Stenosis 1 (4.0%) 2 (7.1%) 0 (NA%) >0.9
Unknown 4 7 25
Ratio.of.2.planes.AP 45 (40, 49) 40 (36, 44) 17 (16, 19) <0.001
Unknown 0 1 20
Ratio.of.2.planes.within.Lat.ventricle.SI 11.6 (9.0, 14.9) 9.8 (8.2, 13.1) 3.8 (3.6, 4.5) <0.001
Unknown 0 1 20
Thickness.of.CC 1.50 (1.30, 1.80) 1.80 (1.50, 2.00) 1.20 (1.10, 1.40) 0.004
Unknown 0 2 20
Chiari 2.0 (0.0, 4.2) 2.0 (0.0, 7.2) 7.7 (6.6, 10.7) <0.001
Unknown 0 0 2
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 19.4 (15.9, 21.0) 17.4 (15.2, 19.0) 6.5 (5.5, 7.3) <0.001
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 43 (39, 52) 37 (33, 46) 22 (18, 23) <0.001
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.00 (1.90, 5.00) 1.90 (1.35, 2.25) 0.00 (0.00, 0.00) <0.001
cortical.thickness 19.4 (15.9, 21.0) 17.4 (15.2, 19.0) 6.5 (5.5, 7.3) <0.001
elongation.of.CP.Glomus 2.70 (2.30, 3.20) 2.50 (2.10, 3.30) 2.80 (2.10, 3.50) 0.6
Unknown 0 2 16
Elongation.of.CP.body 1.60 (1.40, 1.70) 1.30 (1.00, 1.50) 1.90 (1.43, 2.35) 0.003
Unknown 0 2 17
Transependymal.Flow 0 (0%) 0 (0%) 0 (0%)
Unknown 0 0 1
Width.of.L.Atrium 20 (18, 26) 19 (15, 28) 11 (8, 14) <0.001
Unknown 0 0 1
Width.of.R.atrium 16 (15, 21) 16 (14, 25) 11 (7, 13) <0.001
Unknown 0 0 1
1 n (%); Median (IQR)
2 Fisher's exact test; Kruskal-Wallis rank sum test 
#summary of all postnatal cases by timescale 
tbl_summary(df_post[,c(2,6:22)],label = `timescale` ~ "Neuroradiologic Findings",by="timescale")%>%
  bold_labels()  %>%add_p()
Characteristic 1-3mo, N = 81 early, N = 121 p-value2
Deformation.of.Pit.gland 1 (12%) 0 (0%) 0.4
TVFB 0 (0%) 0 (0%)
Bowing.of.LT 1 (12%) 0 (0%) 0.4
Aqueductal.Stenosis 0 (0%) 0 (0%)
Unknown 0 2
Ratio.of.2.planes.AP 48 (45, 51) 41 (35, 45) 0.028
Unknown 1 0
Ratio.of.2.planes.within.Lat.ventricle.SI 14.6 (14.0, 15.3) 12.2 (10.0, 13.4) 0.010
Unknown 1 0
Thickness.of.CC 1.65 (1.50, 1.78) 1.70 (1.55, 1.80) 0.9
Unknown 0 1
Chiari 8.0 (3.9, 10.8) 7.3 (5.4, 15.0) 0.8
Ratio.of.Ventricular.to.Subarachnoid.Space.LV 16.95 (14.20, 18.52) 16.45 (15.70, 17.18) 0.8
Ratio.of.Ventricular.to.Subarachnoid.Space.BF 55 (44, 63) 40 (36, 44) 0.019
Ratio.of.Ventricular.to.Subarachnoid.Space.EA 4.70 (3.95, 6.60) 1.80 (1.45, 2.18) <0.001
cortical.thickness 16.95 (14.20, 18.52) 16.45 (15.70, 17.18) 0.8
elongation.of.CP.Glomus 2.45 (2.15, 2.80) 2.65 (1.90, 3.03) 0.8
Elongation.of.CP.body 0.7
1 2 (25%) 0 (0%)
1.1 0 (0%) 1 (8.3%)
1.3 2 (25%) 5 (42%)
1.4 1 (12%) 1 (8.3%)
1.5 0 (0%) 1 (8.3%)
1.6 1 (12%) 1 (8.3%)
1.7 0 (0%) 1 (8.3%)
1.8 2 (25%) 1 (8.3%)
1.9 0 (0%) 1 (8.3%)
Transependymal.Flow 0 (0%) 0 (0%)
Width.of.L.Atrium 26.1 (20.6, 31.3) 20.2 (16.2, 24.4) 0.2
Width.of.R.atrium 21.9 (17.8, 26.1) 18.4 (15.1, 22.0) 0.2
1 n (%); Median (IQR)
2 Fisher's exact test; Wilcoxon rank sum test; Wilcoxon rank sum exact test