## This is gamm4 0.2-1
Variable UWMC.Cohort.1 UWMC.Cohort.2
Number of Cases 4659 5030
Age
Mean (SD) 50.67 (16.3) 51.93 (16.29)
Gender
% Male 44.92 44.83
BIS
BIS USED (%) 35.76 35.21
ASA (%)
1/2 59.41 58.33
3 37.6 37.36
4 2.98 4.31
EMERGENCY
EMERGENCY (%) 4.19 3.94
Inpatient vs. Outpatient
% Inpatient 41.68 39.78
Maintenance Duration (Hours)
Mean (SD) 0.64 (0.56) 0.66 (0.59)
Inhalational Agent Used (%)
sev 68.94 87.95
iso 2.43 3.5
des 28.63 8.55
MIDAZOLAM PREMEDICATION
MIDAZOLAM PREMEDICATION (%) 69.84 67.91
Fentanyl During Case (mcg)
Mean (SD) 197.79 (121.41) 196.03 (113.49)
PARALYTIC REDOSE AFTER INTUBATION
PARALYTIC REDOSE (%) 54.02 40.08
BUPIVICAINE INFUSION DURING CASE
BUPIVICAINE INFUSION (%) 1.67 3.52
The p values here are based on the bivariate anova : if there's any non-zero different in mean across categories, the p value will be significant. In other words, it's not a particularly conservative test.
In sum : we're looking for variables that appear to correlate with aaMAC, in each site and over time.
Variable UWMC.1.aaMAC p UWMC.2.aaMAC p.1
Age Category
(17,54] 0.9136 0 0.8725 0
(54,65] 0.999 0.9375
(65,75] 1.0126 0.9609
(75,85] 0.9953 0.9737
(85,150] 0.9879 0.945
Gender
Female 0.9356 0 0.8997 2e-04
Male 0.9723 0.9194
BIS
BIS not used 0.9566 0.03455 0.9108 0.23503
BIS used 0.944 0.9043
ASA
1 0.953 0.07571 0.9087 0.14498
3 0.9618 0.9186
4 0.8121 0.8188
ASA EMERGENCY
No 0.9555 0 0.9116 0
Yes 0.8727 0.8341
Patient Type
Inpatient 0.9634 0.00077 0.9217 5e-05
Outpatient 0.944 0.8998
Maintenance Duration (hours)
[0.05,0.267] 0.9195 0 0.8818 0
(0.267,0.5] 0.9486 0.8869
(0.5,0.85] 0.9776 0.9231
(0.85,4.58] 0.9677 0.9448
Inhalational Agent
sev 0.9351 0 0.901 0
iso 0.8439 0.8614
des 1.0022 1.0047
Midazolam Premedication
No 0.9553 0.45554 0.915 0.08924
Yes 0.9507 0.9054
Total Fentanyl (mcg)
[0,100] 0.9023 0 0.8508 0
(100,200] 0.957 0.9117
(200,250] 0.9781 0.9425
(250,2.25e+03] 0.9806 0.9458
Paralytic Redose
No 0.9587 0.03273 0.901 0.00053
Yes 0.9465 0.9197
Regional/Neuraxial
No 0.9535 0.00016 0.9083 0.64065
Yes 0.8695 0.915
Default categoricals : Inpatient, Sevoflurane, ASA = 1
Note : fentanyl reparameterized to fentanyl / 50 to make interpretation of coefficient easier
VAR EST LO95 HI95 P COHORT
friendlySplines(DECADE, 6.5)1 4.9073 4.3056 5.5089 0.0000 2010
friendlySplines(DECADE, 6.5)2 -0.8597 -2.6584 0.9390 0.3489 2010
ANYBIS -3.9842 -5.5119 -2.4565 0.0000 2010
MALE 3.0416 1.8432 4.2401 0.0000 2010
MAINTENANCE_DURATION 0.4935 -0.9504 1.9374 0.5029 2010
PT.CLASSO -2.2250 -3.6331 -0.8168 0.0020 2010
factor(ASA.new)3 -4.6037 -6.1544 -3.0529 0.0000 2010
factor(ASA.new)4 -19.0376 -23.8196 -14.2556 0.0000 2010
EMERGENCY -5.7716 -9.2754 -2.2678 0.0012 2010
MAINAGENTiso -10.6830 -15.4386 -5.9275 0.0000 2010
MAINAGENTdes 6.5435 5.1130 7.9740 0.0000 2010
MIDAZ_PREMED 1.2833 -0.3748 2.9414 0.1293 2010
PARALYTIC_REDOSEYes -2.4585 -3.8564 -1.0606 0.0006 2010
FENTANYL50 1.2365 0.6958 1.7773 0.0000 2010
ANY_BUPIYes -6.9036 -11.0075 -2.7997 0.0010 2010
VAR EST LO95 HI95 P COHORT
friendlySplines(DECADE, 6.5)1 3.9449 3.4274 4.4624 0.0000 2012
friendlySplines(DECADE, 6.5)2 2.0908 0.5353 3.6462 0.0084 2012
ANYBIS -1.9993 -3.2313 -0.7673 0.0015 2012
MALE 1.9614 0.7935 3.1293 0.0010 2012
MAINTENANCE_DURATION 0.5618 -0.9236 2.0472 0.4585 2012
PT.CLASSO -0.5283 -1.9732 0.9166 0.4736 2012
factor(ASA.new)3 -3.4778 -4.7944 -2.1612 0.0000 2012
factor(ASA.new)4 -16.7245 -21.5749 -11.8741 0.0000 2012
EMERGENCY -7.7788 -12.8036 -2.7540 0.0024 2012
MAINAGENTiso -8.2744 -12.4480 -4.1008 0.0001 2012
MAINAGENTdes 10.7609 9.0155 12.5064 0.0000 2012
MIDAZ_PREMED 1.0102 -0.4467 2.4670 0.1741 2012
PARALYTIC_REDOSEYes -0.3509 -1.7531 1.0513 0.6238 2012
FENTANYL50 1.9385 1.5905 2.2865 0.0000 2012
ANY_BUPIYes -2.9479 -6.0127 0.1169 0.0594 2012
Vasopressors
This figure repesents the relationship between measured aaMAC and the mean BIS during maintenance phase of anesthesia (though perhaps median would be preferable, given our use of that population parameter in the rest of our study. Only 66 patients had BIS at HMC during ths study period, and therefore the plot is limited just to cases with BIS at UWMC.