Whole Blood vs Plasma

Linear models: Metal ~ Material

## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   121.8 126.2  -56.9
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:   0.0001886    2.871
## 
## Fixed effects: X27Al ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)     4.333    0.8288 17   5.229   1e-04
## materialplasma -6.000    1.1721 17  -5.119   1e-04
##  Correlation: 
##                (Intr)
## materialplasma -0.707
## 
## Standardized Within-Group Residuals:
##     Min      Q1     Med      Q3     Max 
## -1.1611 -0.4644 -0.2903  0.2322  2.6704 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##       AIC   BIC logLik
##   -0.3792 3.985   4.19
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.3501    0.119
## 
## Fixed effects: log(X52Cr) ~ material 
##                  Value Std.Error DF t-value p-value
## (Intercept)     0.3241    0.1470 17   2.205  0.0415
## materialplasma -0.3621    0.0486 17  -7.450  0.0000
##  Correlation: 
##                (Intr)
## materialplasma -0.165
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -1.61486 -0.42512  0.09768  0.41627  2.12683 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   3.788 8.153  2.106
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.1439   0.1681
## 
## Fixed effects: log(X55Mn) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)     2.161   0.07620 17   28.36       0
## materialplasma -1.654   0.06863 17  -24.10       0
##  Correlation: 
##                (Intr)
## materialplasma -0.45 
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -1.26974 -0.61864 -0.07546  0.66801  1.57988 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   28.56 32.92 -10.28
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:       0.601   0.2375
## 
## Fixed effects: log(X59Co) ~ material 
##                  Value Std.Error DF t-value p-value
## (Intercept)    -0.8574   0.25474 17  -3.366  0.0037
## materialplasma -0.4740   0.09697 17  -4.888  0.0001
##  Correlation: 
##                (Intr)
## materialplasma -0.19 
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -2.12132 -0.53606  0.09482  0.69190  1.21065 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   39.96 44.32 -15.98
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:       1.402     0.26
## 
## Fixed effects: log(X75As) ~ material 
##                  Value Std.Error DF t-value p-value
## (Intercept)     0.3494    0.5772 17   0.605  0.5530
## materialplasma -0.4236    0.1062 17  -3.990  0.0009
##  Correlation: 
##                (Intr)
## materialplasma -0.092
## 
## Standardized Within-Group Residuals:
##     Min      Q1     Med      Q3     Max 
## -1.0555 -0.8593  0.1639  0.8013  0.9448 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##      AIC    BIC logLik
##   -55.24 -50.87  31.62
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:     0.07716  0.03685
## 
## Fixed effects: log(X78Se) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)     4.647   0.03325 17  139.77       0
## materialplasma -0.095   0.01504 17   -6.34       0
##  Correlation: 
##                (Intr)
## materialplasma -0.226
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -1.52265 -0.46025 -0.08334  0.33768  1.71503 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC  BIC logLik
##   12.03 16.4 -2.017
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.1948   0.1978
## 
## Fixed effects: log(X95Mo) ~ material 
##                  Value Std.Error DF t-value p-value
## (Intercept)    -0.4611   0.09790 17  -4.710  0.0002
## materialplasma  0.2647   0.08077 17   3.277  0.0044
##  Correlation: 
##                (Intr)
## materialplasma -0.412
## 
## Standardized Within-Group Residuals:
##     Min      Q1     Med      Q3     Max 
## -1.0809 -0.7181 -0.1076  0.3556  2.4225 
## 
## Number of Observations: 24
## Number of Groups: 6
## Error: NA/NaN/Inf in foreign function call (arg 1)
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   4.605 8.969  1.698
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:        0.22    0.156
## 
## Fixed effects: log(X133Cs) ~ material 
##                  Value Std.Error DF t-value p-value
## (Intercept)     0.8588   0.10045 17   8.549       0
## materialplasma -0.6686   0.06367 17 -10.502       0
##  Correlation: 
##                (Intr)
## materialplasma -0.317
## 
## Standardized Within-Group Residuals:
##     Min      Q1     Med      Q3     Max 
## -1.6784 -0.3913 -0.1980  0.2845  2.0345 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   15.57 19.93 -3.785
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.1454   0.2303
## 
## Fixed effects: log(X138Ba) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)    0.3137   0.08915 17   3.519  0.0026
## materialplasma 0.3342   0.09404 17   3.554  0.0024
##  Correlation: 
##                (Intr)
## materialplasma -0.527
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -1.44094 -0.71018  0.04561  0.36166  2.43940 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   47.83 52.19 -19.91
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.5085   0.4315
## 
## Fixed effects: log(X202Hg) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)    -0.341    0.2421 17  -1.408   0.177
## materialplasma -1.721    0.1762 17  -9.767   0.000
##  Correlation: 
##                (Intr)
## materialplasma -0.364
## 
## Standardized Within-Group Residuals:
##     Min      Q1     Med      Q3     Max 
## -2.7234 -0.4373  0.2155  0.5161  1.2640 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##      AIC    BIC logLik
##   -12.77 -8.406  10.39
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:      0.1751   0.1006
## 
## Fixed effects: log(X205Tl) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)    -3.676   0.07715 17  -47.64       0
## materialplasma  0.483   0.04108 17   11.76       0
##  Correlation: 
##                (Intr)
## materialplasma -0.266
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -2.07413 -0.59428  0.01372  0.27656  1.95539 
## 
## Number of Observations: 24
## Number of Groups: 6
## Linear mixed-effects model fit by REML
##  Data: mydata 
##     AIC   BIC logLik
##   47.53 51.89 -19.76
## 
## Random effects:
##  Formula: ~1 | ID
##         (Intercept) Residual
## StdDev:       0.553   0.4192
## 
## Fixed effects: log(X208Pb) ~ material 
##                 Value Std.Error DF t-value p-value
## (Intercept)     2.556    0.2562 17    9.98       0
## materialplasma -2.383    0.1712 17  -13.92       0
##  Correlation: 
##                (Intr)
## materialplasma -0.334
## 
## Standardized Within-Group Residuals:
##      Min       Q1      Med       Q3      Max 
## -2.17132 -0.47422 -0.03951  0.42784  1.87022 
## 
## Number of Observations: 24
## Number of Groups: 6

Boxplots
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T.Tests

## 
##  Welch Two Sample t-test
## 
## data:  X27Al by material 
## t = 5.119, df = 17.81, p-value = 7.418e-05
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  3.536 8.464 
## sample estimates:
##  mean in group blood mean in group plasma 
##                4.333               -1.667
## 
##  Welch Two Sample t-test
## 
## data:  X52Cr by material 
## t = 1.586, df = 18.7, p-value = 0.1294
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.1123  0.8123 
## sample estimates:
##  mean in group blood mean in group plasma 
##                1.425                1.075
## 
##  Welch Two Sample t-test
## 
## data:  X55Mn by material 
## t = 9.585, df = 11.07, p-value = 1.073e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  5.676 9.057 
## sample estimates:
##  mean in group blood mean in group plasma 
##                9.033                1.667
## 
##  Welch Two Sample t-test
## 
## data:  X59Co by material 
## t = 1.262, df = 21.8, p-value = 0.2204
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.08059  0.33059 
## sample estimates:
##  mean in group blood mean in group plasma 
##               0.4667               0.3417
## 
##  Welch Two Sample t-test
## 
## data:  X75As by material 
## t = 0.3514, df = 21.9, p-value = 0.7287
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -1.798  2.531 
## sample estimates:
##  mean in group blood mean in group plasma 
##                2.567                2.200
## 
##  Welch Two Sample t-test
## 
## data:  X78Se by material 
## t = 2.861, df = 21, p-value = 0.009366
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##   2.616 16.551 
## sample estimates:
##  mean in group blood mean in group plasma 
##               104.67                95.08
## 
##  Welch Two Sample t-test
## 
## data:  X95Mo by material 
## t = -2.273, df = 21.95, p-value = 0.03313
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.35059 -0.01608 
## sample estimates:
##  mean in group blood mean in group plasma 
##               0.6583               0.8417
## 
##  Welch Two Sample t-test
## 
## data:  X111Cd by material 
## t = 9.027, df = 11, p-value = 2.035e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.208 0.342 
## sample estimates:
##  mean in group blood mean in group plasma 
##                0.275                0.000
## 
##  Welch Two Sample t-test
## 
## data:  X133Cs by material 
## t = 5.012, df = 14.68, p-value = 0.0001653
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.6982 1.7351 
## sample estimates:
##  mean in group blood mean in group plasma 
##                2.458                1.242
## 
##  Welch Two Sample t-test
## 
## data:  X138Ba by material 
## t = -2.872, df = 16.12, p-value = 0.011
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -1.0426 -0.1574 
## sample estimates:
##  mean in group blood mean in group plasma 
##                  1.4                  2.0
## 
##  Welch Two Sample t-test
## 
## data:  X202Hg by material 
## t = 6.114, df = 11.85, p-value = 5.51e-05
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.4663 0.9837 
## sample estimates:
##  mean in group blood mean in group plasma 
##               0.8667               0.1417
## 
##  Welch Two Sample t-test
## 
## data:  X205Tl by material 
## t = -6.209, df = 19.95, p-value = 4.639e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.02115 -0.01051 
## sample estimates:
##  mean in group blood mean in group plasma 
##              0.02583              0.04167
## 
##  Welch Two Sample t-test
## 
## data:  X208Pb by material 
## t = 3.158, df = 11.01, p-value = 0.009095
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##   5.508 30.825 
## sample estimates:
##  mean in group blood mean in group plasma 
##                19.42                 1.25

Paired T.Tests

## 
##  Paired t-test
## 
## data:  X27Al by material 
## t = 4.648, df = 11, p-value = 0.0007079
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  3.159 8.841 
## sample estimates:
## mean of the differences 
##                       6
## 
##  Paired t-test
## 
## data:  X52Cr by material 
## t = 5.066, df = 11, p-value = 0.0003627
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.1979 0.5021 
## sample estimates:
## mean of the differences 
##                    0.35
## 
##  Paired t-test
## 
## data:  X55Mn by material 
## t = 9.644, df = 11, p-value = 1.061e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  5.685 9.048 
## sample estimates:
## mean of the differences 
##                   7.367
## 
##  Paired t-test
## 
## data:  X59Co by material 
## t = 9.574, df = 11, p-value = 1.14e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.09626 0.15374 
## sample estimates:
## mean of the differences 
##                   0.125
## 
##  Paired t-test
## 
## data:  X75As by material 
## t = 2.438, df = 11, p-value = 0.03296
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.03559 0.69774 
## sample estimates:
## mean of the differences 
##                  0.3667
## 
##  Paired t-test
## 
## data:  X78Se by material 
## t = 4.881, df = 11, p-value = 0.0004864
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##   5.262 13.905 
## sample estimates:
## mean of the differences 
##                   9.583
## 
##  Paired t-test
## 
## data:  X95Mo by material 
## t = -2.682, df = 11, p-value = 0.02132
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.3338 -0.0329 
## sample estimates:
## mean of the differences 
##                 -0.1833
## 
##  Paired t-test
## 
## data:  X111Cd by material 
## t = 9.027, df = 11, p-value = 2.035e-06
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.208 0.342 
## sample estimates:
## mean of the differences 
##                   0.275
## 
##  Paired t-test
## 
## data:  X133Cs by material 
## t = 5.832, df = 11, p-value = 0.0001138
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.7575 1.6758 
## sample estimates:
## mean of the differences 
##                   1.217
## 
##  Paired t-test
## 
## data:  X138Ba by material 
## t = -2.978, df = 11, p-value = 0.01257
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -1.0435 -0.1565 
## sample estimates:
## mean of the differences 
##                    -0.6
## 
##  Paired t-test
## 
## data:  X202Hg by material 
## t = 6.984, df = 11, p-value = 2.318e-05
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  0.4965 0.9535 
## sample estimates:
## mean of the differences 
##                   0.725
## 
##  Paired t-test
## 
## data:  X205Tl by material 
## t = -10.65, df = 11, p-value = 3.921e-07
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##  -0.01911 -0.01256 
## sample estimates:
## mean of the differences 
##                -0.01583
## 
##  Paired t-test
## 
## data:  X208Pb by material 
## t = 3.2, df = 11, p-value = 0.008463
## alternative hypothesis: true difference in means is not equal to 0 
## 95 percent confidence interval:
##   5.669 30.664 
## sample estimates:
## mean of the differences 
##                   18.17